Murine ortholog of ASC, a CARD-containing protein, self-associates and exhibits restricted distribution in developing mouse embryos

Experimental Cell Research

Volumn 262, Issue 2, 2001, Pages 128-133

  Masumoto, Junya ^a   Taniguchi, Shun'ichiro ^a   Nakayama, Kohzo ^a   Ayukawa, Koichi ^a   Sagara, Junji ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apaf 1; Apoptosis; ASC; CRAD; Distribution; Embryos; Mouse; Oligomerization

Indexed keywords

AMINO ACID; APOPTOSIS ASSOCIATED SPECK LIKE PROTEIN CONTAINING A CARD; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE; CELL PROTEIN; GREEN FLUORESCENT PROTEIN; PROTEIN ASC; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CASPASE RECRUITMENT DOMAIN; CELL STRAIN COS7; CONTROLLED STUDY; DIENCEPHALON; EMBRYO; EMBRYO DEVELOPMENT; FIBROBLAST; GENE EXPRESSION; HEART; IN SITU HYBRIDIZATION; LIVER; MOLECULAR CLONING; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN LOCALIZATION; TELENCEPHALON; THALAMUS;

EID: 0035862186     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.5078     Document Type: Article

References (24)

1. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
2. Programmed cell death in animal development
3. Caspases: The proteases of the apoptotic pathway
4. The CARD domain: A new apoptotic signalling motif
5. Caspase activation: The induced-proximity model
6. The modular nature of apoptotic signaling proteins
7. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
8. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
9. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
10. RAIDD is a new 'death' adaptor molecule
11. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP
12. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death
13. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
14. RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis
15. RIP2 is a novel NF-κB-activating and cell death-inducing kinase
16. Identification of CARDIAK, a RIP-like kinase that associates with caspase-1
17. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-κB
18. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-κB
19. ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells
20. Differential expression of moesin in cells ofhematopoietic lineage and lymphatic systems
21. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever
22. Apaf1 is required for mitochondrial pathways of apoptosis and brain development
23. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
24. Essential role of CED-4 oligomerization in CED-3 activation and apoptosis