Increased anxiety and impaired memory in rats 3 months after administration of 3,4-methylenedioxymethamphetamine ("Ecstasy")

European Journal of Pharmacology

Volumn 433, Issue 1, 2001, Pages 91-99

  Morley, Kirsten C ^a   Gallate, Jason E ^a   Hunt, Glenn E ^a   Mallet, Paul E ^b   McGregor, Iain S ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF NEW ENGLAND   (Australia)

Author keywords

(Rat); Anxiety; Ecstasy; MDMA (3,4 methylenedioxymethamphetamine); Memory; Neurotoxicity

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; DEXAMPHETAMINE; DRUG VEHICLE; SEROTONIN;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY NEUROSIS; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG MEGADOSE; HYPERACTIVITY; HYPERTHERMIA; MALE; MAZE TEST; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECOGNITION; SEROTONIN BRAIN LEVEL; SOCIAL INTERACTION; TASK PERFORMANCE; TIME;

ANIMALS; ANXIETY; BODY TEMPERATURE; MALE; MAZE LEARNING; MEMORY DISORDERS; MOTOR ACTIVITY; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; RATS; RATS, WISTAR; SOCIAL BEHAVIOR; STREET DRUGS;

EID: 0035861913     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01512-6     Document Type: Article

References (53)

1. One-trial object-recognition by rats
2. Behavioral tests for the recognition of non-spatial information by rats
3. Aniracetam restores object recognition impaired by age, scopolamine, and nucleus basalis lesions
4. 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: Quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites
5. Historical effects of stimulus exposure; readiness to eat and object exploration
6. MDMA (Ecstasy) neurotoxicity: Assessing and communicating the risks
7. Sexual behavior induction of c-Fos in the nucleus accumbens and amphetamine-stimulated locomotor activity are sensitized by previous sexual experience in female Syrian hamsters
8. Serotonin release contributes to the locomotor stimulant effects of 3,4-methylenedioxymethamphetamine in rats
9. Time course of brain temperature and caudate/putamen microdialysate levels of amphetamine and dopamine in rats after multiple doses of D-amphetamine
10. Amphetamine levels in brain microdialysate, caudate/putamen, substantia nigra and plasma after dosage that produces either behavioral or neurotoxic effects
11. The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype
12. Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines
13. Effect of ambient temperature on hyperthermia and hyperkinesis induced by 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") in rats
14. Hyperthermia following MDMA administration in rats: Effects of ambient temperature, water consumption, and chronic dosing
15. Evidence for depletion of brain DA, 5-HT and 5-HIAA concentrations following 3,4-methylenedioxymethamphetamine (MDMA or 'Ecstasy') administration in rats
16. The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs
17. Animal models for predicting clinical efficacy of anxiolytic drugs: Social behaviour
18. Animal models of different anxiety states
19. Reorganization of ascending 5-HT axon projections in animals previously exposed to the recreational drug (+/-)3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy')
20. Mood state and brain electric activity in ecstasy users
21. Long-lasting effects of (+/-)3,4-methylenedioxymethamphetamine (ecstasy) on serotonin system function in humans
22. A role for the mesolimbic dopamine system in the psychostimulant actions of MDMA
23. Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat
24. Pharmacological characterisation of a modified social interaction model of anxiety in the rat
25. Effects of 5,7-dihydroxytryptamine depletion of tissue serotonin levels on extracellular serotonin in the striatum assessed with in vivo microdialysis: Relationship to behavior
26. 5-HT drugs in animal models of anxiety
27. A new approach to the light/dark test procedure in mice
28. MDMA elicits behavioral and neurochemical sensitization in rats
29. Behavioral characterization of alpha-ethyltryptamine, a tryptamine derivative with MDMA-like properties in rats
30. Electron microscopic evidence for neurotoxicity in the basal ganglia
31. Ethologically-based animal models of anxiety disorders
32. Small changes in ambient temperature cause large changes in 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat
33. Behavioural analysis of the acute and chronic effects of MDMA treatment in the rat
34. Cognitive performance in (+/-) 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") users: A controlled study
35. Using Strawberry Tree WorkbenchMac and Workbench PC software for data acquisition and control in the animal learning laboratory
36. Analgesia and decrement in operant performance in socially defeated mice: Selective cross-tolerance to morphine and antagonism by naltrexone
37. Neurotoxicity of MDMA and related compounds: Anatomic studies
38. Ecstasy (MDMA): A review of its possible persistent psychological effects
39. (+/-)-3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') increases social interaction in rats
40. TMT, a predator odor, elevates mesoprefrontal dopamine metabolic activity and disrupts short-term working memory in the rat
41. Psychobiological problems in heavy 'ecstasy' (MDMA) polydrug users
42. Validation of open: Closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
43. Memory disturbances in "Ecstasy" users are correlated with an altered brain serotonin neurotransmission
44. Lasting effects of (+/-)-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: Neurochemical observations
45. 3,4-Methylenedioxymethamphetamine, serotonin and memory
46. Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis
47. Histological and ultrastructural evidence that D-amphetamine causes degeneration in neostriatum and frontal cortex of rats
48. Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA ('Ecstasy') users
49. Behavioral and neurochemical effects of orally administered MDMA in the rodent and nonhuman primate
50. The distribution of 3,4-methylenedioxymethamphetamine "Ecstasy"-induced c-fos expression in rat brain
51. Ecstasy use in Australia: Patterns of use and associated harm
52. Cognitive performance and serotonergic function in users of ecstasy
53. Working memory deficits in current and previous users of MDMA ('ecstasy')