Heregulin induces in vivo proliferation and differentiation of mammary epithelium into secretory lobuloalveoli

Cell Growth and Differentiation

Volumn 7, Issue 8, 1996, Pages 1031-1038

  Jones, Frank E ^a   Joseph Jerry, D ^b   Guarino, Brad C ^c   Andrews, Glenn C ^c   Stern, David F ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; NEU DIFFERENTIATION FACTOR; TRANSFORMING GROWTH FACTOR ALPHA;

ARTICLE; BREAST EPITHELIUM; CELL DIFFERENTIATION; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; ESTRADIOL BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL;

ANIMALS; ANIMALS, NEWBORN; CASEINS; CELL DIFFERENTIATION; CELL DIVISION; EPITHELIAL CELLS; EPITHELIUM; ESTRADIOL; FEMALE; GLYCOPROTEINS; IMMUNOHISTOCHEMISTRY; MAMMARY GLANDS, ANIMAL; MICE; MICE, INBRED BALB C; NEUREGULINS; PROGESTERONE; TRANSFORMING GROWTH FACTOR BETA;

EID: 10244279259     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Daniel, C. W., and Silberstein, G. B. Postnatal development of the rodent mammary gland. In: M. C. Neville and C. W. Daniel (eds.), The Mammary Gland: Development, Regulation, and Function, pp. 3-36. New York: Plenum Publishing Corp., 1987.
2. Russo, J., and Russo, I. H. Development of the human mammary gland. In: M. C. Neville and C. W. Daniel (eds.), The Mammary Gland: Development, Regulation, and Function, pp. 67-93. New York: Plenum Publishing Corp., 1987.
3. Topper, Y. J., and Freeman, C. S. Multiple hormone interactions in the developmental biology of the mammary gland. Physiol. Rev., 50: 1049-1106, 1980.
4. Vonderhaar, B. K. Hormones and growth factors in mammary gland development. In: C. M. Veneziale (eds.), Control of Cell Growth and Proliferation, pp. 11-33. Princeton, NJ: van Nostrand-Reinhold, 1984.
5. Dembinski, T. C., and Shiu, R. P. C. Growth factors in mammary gland development and function. In: M. C. Neville and C. W. Daniel (eds.), The Mammary Gland: Development, Regulation, and Function, pp. 355-381. New York: Plenum Publishing Corp., 1987.
6. Bates, S. E., Davidson, N. E., Valverius, E. M., Freter, C. E., Dickson, R. B., Tam, J. P., Kudlow, J. E., Lippman, M. E., and Salomon, D. S. Expression of transforming growth factor α and its messenger ribonucleic acid in human breast cancer: its regulation by estrogen and its possible functional significance. Mol. Endocrinol., 2: 543-555, 1988.
7. Salomon, D. S., Kidwell, W. R., Kin, N., Ciardiello, F., Bates, S. E., Valverius, E. M., Lippman, M. E., Dickson, R. B., and Stampfer, M. R. Modulation by estrogen and growth factors of transforming growth factor-α and epidermal growth factor expression in normal and malignant human mammary epithelial cells. Recent Results Cancer Res., 113: 57-69, 1989.
8. Hiramatsu, M., Kashimata, M., Takayama, F., and Minami, N. Developmental changes in and hormonal modulation of epidermal growth factor concentration in the rat submandibular gland. J. Endocrinol., 140: 357-363, 1994.
9. Martinez-Lacaci, I., Saceda, M., Plowman, G. D., Johnson, G. R., Normanno, N., Salomon, D. S., and Dickson, R. B. Estrogen and phorbol esters regulate amphiregulin expression by two separate mechanisms in human breast cancer cell lines. Endocrinology, 136: 3983-3992, 1995.
10. Mouihate, A., and Lestage, J. Estrogen increases the release of epidermal growth factor from individual pituitary cells in female rats. J. Endocrinol., 146: 495-500, 1995.
11. Salomon, D. S., Brandt, R., Ciardiello, F., and Normanno, N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol., 19: 183-232, 1995.
12. Snedeker, S. M., Brown, C. F., and DiAugustine, R. P. Expression and functional properties of transforming growth factor α and epidermal growth factor during mouse mammary gland ductal morphogenesis. Proc. Natl. Acad. Sci. USA, 83: 276-280, 1991.
13. Liu, S. C., Sanfilippo, B., Perroteau, I., Derynck, R., Salomon, D. S., and Kidwell, W. R. Expression of transforming growth factor α (TGFα) in differentiated rat mammary tumors: estrogen induction of TGFα production. Mol. Endocrinol., 1: 683-692, 1987.
14. Smith, J. A., Barraclough, R., Fernig, D. G., and Rudland, P. S. Identification of α transforming growth factor as a possible local trophic agent for the mammary gland. J. Cell. Physiol., 141: 362-370, 1989.
15. Liscia, D. S., Merlo, G., Ciardiello, F., Kim, N., Smith, G. H., Callahan, R., and Salomon, D. S. Transforming growth factor-α messenger RNA: localization in the developing adult rat and human mammary gland by in situ hybridization. Dev. Biol., 140: 123-131, 1990.
16. Panico, L., D'Antonio, A., Salvatore, G., Mezza, E., Tortora, G., DeLaurentiis, M., DePlacido, S., Giordano, T., Merino, M., Salomon, D. S., Gullick, W. J., Pettinato, G., Schnitt, S. J., Bianco, A. R., and Ciardiello, F. Differential immunohistochemical detection of transforming growth factor α, amphiregulin, and cripto in human normal and malignant breast tissues. Int. J. Cancer, 65: 51-56, 1996.
17. Qi, C-F., Liscia, D. S., Normanno, N., Merlo, G., Johnson, G., Gullick, W. J., Ciardiello, F., Saeki, T., Brandt, R., Kim, N., Kenney, N., and Salomon, D. S. Expression of transforming growth factor α, amphiregulin, and cripto-1 in human breast carcinomas. Br. J. Cancer, 69: 903-910, 1994.
18. Kenney, N. J., Huang, R-P., Johnson, G. R., Wu, J-X., Okamura, D., Matheny, W., Kordon, E., Gullick, W. J., Plowman, G., Smith, G. H., Salomon, D. S., and Adamson, E. D. Detection and localization of amphiregulin and cripto-1 expression in the developing postnatal mouse mammary gland. Mol. Reprod. Dev., 41: 277-286, 1995.
19. Yang, Y., Spitzer, E., Meyer, D., Sachs, M., Niemann, C., Hartmann, G., Weidner, K. M., Birchmeier, C., and Birchmeier, W. Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland. J. Cell Biol., 131: 215-226, 1995.
20. Coleman, S., Silberstein, G. B., and Daniel, C. W. Ductal morphogenesis in the mouse mammary gland: evidence supporting a role for epidermal growth factor. Dev. Biol., 127: 304-315, 1988.
21. Gullick, W. J. The role of the epidermal growth factor receptor and the c-erbB-2 protein in breast cancer. Int. J. Cancer, 5 (Suppl.): 55-61, 1990.
22. Press, M. F., Cordon-Cardo, C., and Slamon, D. J. Expression of the Her-2/neu proto-oncogene in normal adult and fetal tissues. Oncogene, 5: 953-962, 1990.
23. Manning, D. L., Nicholson, R. I., and Eaton, C. L. Role of oestrogens and growth factors in the aetiology of breast cancer. Recent Adv. Endocrinol. Metab., 27: 133-149, 1992.
24. Hynes, N. E., and Stern, D. F. The biology of erbB-2/neu/HER-2 and its role in cancer. Biochim. Biophys. Acta, 1198: 165-184, 1994.
25. Dickson, R. B., and Lippman, M. E. Growth factors in breast cancer. Endocr. Rev., 16: 559-589, 1995.
26. Lee, D. C., Fenton, S. E., Berkowitz, E. A., and Hissong, M. A. Transforming growth factor α: expression, regulation, and biological activities. Pharmacol. Rev., 47: 51-85, 1995.
27. Nguyen, B., Keane, M. M., and Johnston, P. G. The biology of growth regulation in normal and malignant breast epithelium: from the bench to clinic. Crit. Rev. Oncol. Hematol., 20: 223-236, 1995.
28. Lu, H. S., Chang, D., Philo, J. S., Zhang, M., Sun, J., Wen, J., Yanagihara, D., Karunagaran, D., Yarden, Y., and Ratzkin, B. Studies on the structure and function of glycosylated and nonglycosylated neu differentiation factors. J. Biol. Chem., 270: 4784-4791, 1995.
29. Marikovsky, M., Lavi, S., Pinkas-Kramarski, R., Karunagaran, D., N. L., Wen, D., and Yarden, Y. ErbB-3 mediates differential mitogenic effects of NDF/heregulin isoforms on mouse keratinocytes. Oncogene, 10: 1403-1411, 1995.
30. Marte, B. M., Graus-Porta, D., Jeschke, M., Fabbro, D., Hynes, N. E., and Taverna, D. NDF/heregulin activates MAP kinase and p70/p85 S6 kinase during proliferation or differentiation of mammary epithelial cells. Oncogene, 10: 167-175, 1995.
31. Ram, T. G., Kokeny, K. E., Dilts, C. A., and Ethier, S. P. Mitogenic activity of neu differentiation factor/heregulin mimics that of epidermal growth factor and insulin-like growth factor-1 in human mammary epithelial cells. J. Cell. Physiol., 163: 589-596, 1995.
32. Peles, E., Bacus, S. S., Koski, R. A., Lu, H. S., Wen, D., Ogden, S. G., Ben Levy, R., and Yarden, Y. Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells. Cell, 69: 205-216, 1992.
33. Wen, D., Peles, E., Cupples, R., Suggs, S. V., Bacus, S. S., Luo, Y., Trail, G., Hu, S., Silbiger, S. M., Levy, R. B., Koski, R. A., Lu, H. S., and Yarden, Y. Neu differentiation factor: a transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit. Cell, 69: 559-572, 1992.
34. Bacus, S. S., Gudkov, A. V., Zelnick, C. R., Chin, D., Stern, R., Stancovski, I., Peles, E., Ben Baruch, N., Farbstein, H., Lupu, R., Wen, D., Sela, M., and Yarden, Y. Neu differentiation factor (heregulin) induces expression of intracellular adhesion molecule 1: implication for mammary tumors. Cancer Res., 53: 5251-5261, 1993.
35. erbB4 receptor. J. Biol. Chem., 268: 18407-18410, 1993.
36. Mudge, A. W. New ligands for neu? Curr. Biol., 3: 361-364, 1993.
37. Vonderhaar, B. K. Local effects of EGF, α-TGF, and EGF-like growth factors on lobuloalveolar development of the mouse mammary gland in vivo. J. Cell. Physiol., 132: 581-584, 1987.
38. Tonelli, Q. J., and Sorof, S. Epidermal growth factor requirement for development of cultured mammary gland. Nature (Lond.), 285: 250-252, 1980.
39. Lydon, J. P., DeMayo, F. J., Funk, C. R., Mani, S. K., Hughes, A. R., Montgomery, C. A., Jr., Shyamala, G., Conneely, O. M., and O'Malley, B. W. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev., 9: 2266-2278, 1995.
40. Saeki, T., Cristiano, A., Lynch, M. J., Brattain, M., Kim, N., Normanno, N., Kenney, N., Ciardiello, F., and Salomon, D. S. Regulation by estrogen through the 5′-flanking region of the transforming growth factor α gene. Mol. Endocrinol., 5: 1955-1963, 1991.
41. Normanno, N., Qi, C-F., Gullick, W. J., Persico, G., Yarden, Y., Wen, D., Plowman, G., Kenney, N., Johnson, G., Kim, N., Brandt, R., Martinez-Lacaci, I., Dickson, R. B., and Salomon, D. S. Expression of amphiregulin, cripto-1, and heregulin α in human breast cancer cells. Int. J. Oncol., 2: 903-911, 1993.
42. neu: a potential model for receptor interactions. EMBO J., 7: 995-1001, 1988.
43. Goldman, R., Levy, B. R., Peles, E., and Yarden, Y. Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation. Biochemistry, 29: 11024-11028, 1990.
44. neu protein and EGF receptor modulates EGF receptor function. Cell, 67: 1339-1347, 1990.
45. Earp, H. S., Dawson, T. L., Li, X., and Yu, H. Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer research. Breast Cancer Res. Treat., 35: 115-132, 1995.
46. Sliwkowski, M., Schaefer, G., Akita, R. W., Lofgren, J. A., Fitzpatrick, V. D., Nuijens, A., Fendly, B. M., Cerione, R. A., Vandlen, R. L., and Carraway, K. L., III. Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin. J. Biol. Chem., 269: 14661-14665, 1994.
47. Tzahar, E., Levkowitz, G., Karunagaran, D., Yi, L., Peles, E., Lavi, S., Chang, D., Liu, N., Yayon, A., Wen, D., and Yarden, Y. ErbB-3 and erbB-4 function as respective low and high affinity receptors of all neu differentiation factor/heregulin isoforms. J. Biol. Chem., 269: 25226-25233, 1994.
48. Riese, D. J., II, van Raaij, T. M., Plowman, G. D., Andrews, G. C., and Stern, D. F. Cellular response to neuregulins is governed by complex interactions of the erbB receptor family. Mol. Cell. Biol., 15: 5770-5776, 1995.
49. DiFiore, P. P., Segatto, O., Taylor, W. G., Aaronson, S. A., and Pierce, J. H. EGF receptor and erbB-2 tyrosine kinase domains confer cell specificity for mitogenic signaling. Science (Washington DC), 248: 79-83, 1990.
50. Riese, D. J., II, Bermingham, Y., Raaij, T. M. v., Buckley, S., Plowman, G. D., and Stem, D. F. Betacellulin activates the epidermal growth factor receptor and erbB-4 and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-β. Oncogene, 12: 345-353, 1996.
51. Zhang, K., Sun, J., Liu, N., Wen, D., Chang, D., Thomason, A., and Yoshinaga, S. K. Transformation of NIH 3T3 cells by HER3 or HER4 receptors requires the presence of HER1 or HER2. J. Biol. Chem., 271: 3884-3890, 1996.
52. Lee, K-F., Simon, H., Chen, H., Bates, B., Hung, M-C., and Hauser, C. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature (Lond.), 378: 394-398, 1995.
53. Meyer, D., and Birchmeier, C. Multiple essential functions of neuregulin in development. Nature (Lond.), 378: 386-390, 1995.
54. erbB2. Science (Washington DC), 256: 1205-1210, 1992.
55. Sambrook, S., Fritsch, E. F., and Maniatis, T. Molecular Cloning: a Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1989.
56. Barbacci, E. G., Guarino, B. C., Stroh, J. G., Singleton, D. H., Rosnack, K. J., Moyer, J. D., and Andrews, G. C. The structural basis for the binding specificity of epidermal growth factor and heregulin binding. J. Biol. Chem., 270: 9585-9589, 1995.
57. Silberstein, G. B., and Daniel, C. W. Reversible inhibition of mammary gland growth by transforming growth factor-β. Science (Washington DC), 237: 291-293, 1987.