Role of Fas-Fas ligand interactions in 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD)-induced immunotoxicity: Increased resistance of thymocytes from Fas-deficient (lpr) and fas ligand-defective (gld) mice to TCDD-induced toxicity

Toxicology and Applied Pharmacology

Volumn 160, Issue 2, 1999, Pages 141-155

  Kamath, Arati B ^a   Camacho, Iris ^b   Nagarkatti, Prakash S ^b   Nagarkatti, Mitzi ^a  

^a VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; Caspase; Fas; Immunotoxicity; TCDD; Thymocytes

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CALPASTATIN; CASPASE INHIBITOR; CELL SURFACE MARKER; FAS ANTIGEN; FAS LIGAND; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DENSITY; CONTROLLED STUDY; CYTOPATHOLOGY; DOSE RESPONSE; FEMALE; IMMUNOPHENOTYPING; IMMUNOTOXICITY; LIGAND BINDING; MOUSE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; THYMOCYTE; THYMUS ATROPHY;

ANIMALIA;

EID: 0032725896     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1999.8753     Document Type: Article

References (33)

1. Ashida H., Matsumura F. Effect of in vivo administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on DNA-binding activities of nuclear transcription factors in liver of guinea pigs. J. Biochem. Mol. Toxicol. 12:1998;191-204.
2. Blaylock B. L., Holladay S. D., Comment C. E., Heindell J. J., Luster M. I. Exposure to tetrachlorodibenzo-p-dioxin (TCDD) alters fetal thymocyte maturation. Toxicol. Appl. Pharmacol. 112:1992;207-213.
3. Choi E. J., Toscano D. J., Ryan J. A., Reidel N., Toscano W. A. Jr. Dioxin induces transforming growth factor-alpha in human keratinocytes. J. Biol. Chem. 266:1991;9591-9597.
4. Critchfield J. M., Racke M. K., Zuniga-Pflucker J. C., Cannella B., Raine C. S., Goverman J., Lenardo M. J. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science. 263:1994;1139-1143.
5. Dohr O., Vogel C., Abel J. Modulation of growth factor expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Exp. Clin. Immunogenet. 11:1994;142-148.
6. Fine J. S., Gasiewicz T. A., Silverstone A. E. Lymphocyte stem cell alterations following perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Mol. Pharmacol. 35:1989;18-25.
7. Fine J. S., Silverstone A. E., Gasiewicz T. A. Impairment of prothymocyte activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J. Immunol. 144:1990;1169-1176.
8. French L. E., Wilson A., Hahne M., Viard I., Tschopp J., MacDonald H. R. Fas ligand expression is restricted to nonlymphoid thymic components in situ. J. Immunol. 159:1997;2196-2202.
9. Froelich C. J., Dixit V. M., Yang X. Lymphocyte granule-mediated apoptosis: Matters of viral mimicry and deadly proteases. Immunol. Today. 19:1998;30-36.
10. Greenlee W. F., Dold K. M., Irons R. D., Osborne R. Evidence for direct action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on thymic epithelium. Toxicol. Appl. Pharmacol. 79:1985;112-120.
11. Hammond D. M., Nagarkatti P. S., Gote L. R., Seth A., Hassuneh M. R., Nagarkatti M. Double-negative T cells from MRL-lpr/lpr mice mediate cytolytic activity when triggered through adhesion molecules and constitutively express perforin gene. J. Exp. Med. 178:1993;2225-2230.
12. Holladay S. D., Lindstrom P., Blaylock B. L., Comment C. E., Germolec D. R., Heindell J. J., Luster M. I. Perinatal thymocyte antigen expression and postnatal immune development altered by gestation exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Teratology. 144:1991;385-393.
13. Hughes D. P. M., Crispe I. N. A naturally occurring soluble isoform of murine Fas generated by alternative splicing. J. Exp. Med. 182:1995;1395-1401.
14. Kamath A. B., Nagarkatti P. S., Nagarkatti M. Characterization of phenotypic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on thymocytes in vivo and its effects on apoptosis. Toxicol. Appl. Pharmacol. 150:1998;117-124.
15. Kamath A. B., Xu H., Nagarkatti P. S., Nagarkatti M. Evidence for the induction of apoptosis in thymocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in vivo. Toxicol. Appl. Pharmacol. 142:1997;367-377.
16. Kasibhatla S., Brunner T., Genestier L., Echeverri F., Mahboubi A., Green D. R. DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1. Mol. Cell. 1:1998;543-551.
17. Kerkvliet N. I., Brauner J. A. Flow cytometric analysis of lymphocyte subpopulations in the spleen and thymus of mice exposed to an acute immunosuppressive dose 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Environ. Res. 52:1990;146-154.
18. Kishimoto H., Surh C. D., Sprent J. Upregulation of surface markers on dying thymocytes. J. Exp. Med. 181:1995;649-655.
19. Kremer J., Lai Z. W., Esser C. Evidence for the promotion of positive selection of thymocytes by Ah receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin. Eur. J. Pharmacol. 293:1995;413-427.
20. Lai Z. W., Pineau T., Esser C. Identification of dioxin-responsive elements (DREs) in the 5′ regions of putative dioxin-inducible genes. Chem. Biol. Interact. 100:1996;97-112.
21. Livingston D. J. In vivo and in vitro studies of ICE inhibitors. J. Cell. Biochem. 64:1997;19-26.
22. Lundberg K., Grovnik K. O., Goldschmidt T. J., Klareskog L., Dencker L. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters intrathymic T cell development in mice. Chem. Biol. Interact. 74:1990;179-193.
23. Nagarkatti P. S., Sweeney G. D., Gauldie J., Clark D. A. Sensitivity to suppression of cytotoxic T cell generation 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on the phenotype of the murine host. Toxicol. Appl. Pharmacol. 72:1984;169-176.
24. Nagata S. Apoptosis by death factor. Cell. 88:1997;355-365.
25. Poland A., Knutson J. C. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol. 22:1982;517-554.
26. Pryputniewicz S. J., Nagarkatti M., Nagarkatti P. S. Differential induction of apoptosis in activated and resting T cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and its repercussion on T cell responsiveness. Toxicology. 129:1998;211-226.
27. Rhile M. J., Nagarkatti M., Nagarkatti P. S. Role of Fas apoptosis and MHC genes in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunotoxicity of T cells. Toxicology. 110:1996;153-167.
28. Sato K., Kimura F., Nakamura Y., Murakami H., Yoshida M., Tanaka M., Nagata S., Kanatani Y., Wakimoto N., Nagata N., Motoyoshi K. An aggressive nasal lymphoma accompanied by high levels of soluble Fas ligand. Br. J. Haematol. 94:1996;379-382.
29. Savill J., Fadok V., Henson P., Haslett C. Phagocytic recognition of cells undergoing apoptosis. Immunol. Today. 14:1993;131-136.
30. Suda T., Okazaki T., Naito Y., Yokota T., Arai N., Ozaki S., Nakao K., Nagata S. Expression of the Fas ligand in cells of T cell lineage. J. Immunol. 154:1995;3806-3813.
31. Sutter T. R., Guzman K., Dold K. M., Greenlee W. F. Targets for dioxin: Genes for plasminogen activator inhibitor-2 and interleukin-1β Science. 254:1991;415-418.
32. Suzuki I., Fink P. J. Maximal proliferation of cytotoxic T lymphocytes requires reverse signaling through Fas ligand. J. Exp. Med. 1:1998;123-128.
33. Zeytun A., Hassuneh M., Nagarkatti M., Nagarkatti P. S. Fas-Fas ligand-based interactions between tumor cells and tumor-specific cytotoxic T lymphocytes: A lethal two-way street. Blood. 90:1997;1952-1959.