Deposition of Alzheimer's vascular amyloid-β is associated with decreased expression of brain L-3-hydroxyacyl-coenzyme A dehydrogenase (ERAB)

Brain Research

Volumn 907, Issue 1-2, 2001, Pages 44-53

  Frackowiak, Janusz ^a   Mazur Kolecka, Bozena ^a   Kaczmarski, Wojciech ^a   Dickson, Dennis ^b  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^b MAYO CLINIC   (United States)

Author keywords

A blinding protien; Alzheimer's disease; Cell culture; ERAB; L 3 hydroxyacyl coenzyme A dehydrogenase; Smooth muscle cells; Vascular amyloidosis

Indexed keywords

3 HYDROXYACYL COENZYME A DEHYDROGENASE; AMYLOID; AMYLOID BETA PROTEIN;

AGE DISTRIBUTION; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN BLOOD VESSEL; BRAIN MITOCHONDRION; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IN VIVO STUDY; MOUSE; NEUROPIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; SMOOTH MUSCLE FIBER; VASCULAR AMYLOIDOSIS; VASCULAR SMOOTH MUSCLE;

3-HYDROXYACYL COA DEHYDROGENASES; ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ALCOHOL OXIDOREDUCTASES; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CARRIER PROTEINS; CELLS, CULTURED; CEREBRAL AMYLOID ANGIOPATHY; CHILD; ENZYME INDUCTION; FEMALE; HUMANS; MALE; MENINGES; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; MITOCHONDRIA; MUSCLE, SMOOTH, VASCULAR; NERVE TISSUE PROTEINS; NEUROGLIA; NEURONS; ORGAN SPECIFICITY; PROTEIN BINDING; TUNICA MEDIA;

EID: 0035854582     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02497-0     Document Type: Article

References (30)

1. Generation of β-amyloid in the secretory pathway in neuronal and nonneuronal cells
2. Alzheimer's Aβ(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells
3. Non-fibrillar β-amyloid protein is associated with smooth muscle cells of vessel walls in Alzheimer disease
4. Culture of canine vascular myocytes as a model to study production and accumulation of β-protein by cells involved in amyloidogenesis
5. Secretion and accumulation of β-protein by cultured vascular smooth muscle cells from old and young dogs
6. Factors secreted by activated microglia and monocytes reduce amyloidogenesis in vascular smooth muscle cells
7. Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides
8. Targetting of cell-surface β amyloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments
9. A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid β-peptide-binding protein involved in Alzheimer's disease
10. Human brain short L-3-hydoxyacyl Coenzyme A dehydrogenase is a single-domain multifunctional enzyme
11. Molecular mechanism of mitochondrial short chain L-3-hydoxyacyl Coenzyme A dehydrogenase (SCHAD) inivolved in Alzheimer's disease
12. Inhibition of β-amyloid formation identifies proteolytic precursors and subcellular site of catabolism
13. Detection and quantitation of amyloid β-peptide with two monoclonal antibodies
14. Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular A-beta stabilization
15. Intracellular accumulation of beta-amyloid in cells expressing Swedish mutant amyloid precursor protein
16. Accumulation of Alzheimer's amyloid-β peptide in cultured myocytes is enhanced by serum and reduced by cerebrospinal fluid
17. Apolipoproteins E3 and E4 induce, and transthyretin prevents accumulation of the Alzheimer's β-amyloid peptide in cultured vascular smooth muscle cells
18. Factors produced by activated macrophages reduce accumulation of Alzheimer's β-amyloid protein in vascular smooth muscle cells
19. Apolipoprotein E alters metabolism of AβPP in cells engaged in β-amyloidosis
20. Binding of amyloid β-peptide to mitochondrial hydroxyacyl-CoA dehydrogenase (ERAB): Regulation of an SDR enzyme activity with implications for apoptosis in Alzheimer's disease
21. ERAB contains a putative noncleavable signal peptide
22. Intracellular and secreted Alzheimer β-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons
23. Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway
24. Microglial cells are the driving force in fibrillar amyloid formation, whereas astrocytes are a leading factor in plaque degradation
25. Intracellular generation and accumulation of amyloid β-peptide terminating at amino acid 42
26. Vascular β-amyloid in Alzheimer disease angiopathy is produced by proliferating and degenerating smooth muscle cells
27. In vitro production of β-protein in smooth muscle cells isolated from amyloid angiopathy-affected vessels
28. β-amyloid formation by myocytes of leptomeningeal vessels
29. An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease
30. Role of ERAB/L-3-hydroxyacyl-coenzyme A dehydrogenase type II activity in Aβ-induced cytotoxicity