Purification, Enzymatic Characterization, and Inhibition of the Z-Farnesyl Diphosphate Synthase from Mycobacterium tuberculosis

Journal of Biological Chemistry

Volumn 276, Issue 15, 2001, Pages 11624-11630

  Schulbach, Mark C ^a   Mahapatra, Sebabrata ^a   Macchia, Marco ^b   Barontini, Silvia ^b   Papi, Chiara ^b   Minutolo, Filippo ^b   Bertini, Simone ^b   Brennan, Patrick J ^a   Crick, Dean C ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; BRAIN; ENZYME INHIBITION; GENES; PH;

GENOME SEQUENCES; MYCOBACTERIUM TUBERCULOSIS;

ENZYMES;

CATION; DECAPRENYL PHOSPHATE; GALACTAN; GENE PRODUCT; GERANYLTRANSFERASE; LIPOARABINOMANNAN; PEPTIDOGLYCAN; PHOSPHATE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; PRIMER DNA; TRANSFERASE;

ANIMAL TISSUE; ARTICLE; BACTERIAL CELL WALL; BRAIN TISSUE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME PURIFICATION; GENE SEQUENCE; GENETIC CODE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OPEN READING FRAME; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SWINE; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; ISOLATION AND PURIFICATION; METABOLISM; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN CONFORMATION; THIN LAYER CHROMATOGRAPHY;

ACTINOBACTERIA (CLASS); ANIMALIA; BACTERIA (MICROORGANISMS); MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; PROKARYOTA; SUS; SUS SCROFA; UNCULTURED ACTINOMYCETE;

ALKYL AND ARYL TRANSFERASES; ANIMALS; BASE SEQUENCE; CHROMATOGRAPHY, THIN LAYER; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; GERANYLTRANSTRANSFERASE; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; SWINE;

EID: 0035853684     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M007168200     Document Type: Article

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