Model prodrugs for the intestinal oligopeptide transporter: Model drug release in aqueous solution and in various biological media

Journal of Controlled Release

Volumn 73, Issue 1, 2001, Pages 21-30

  Nielsen, Carsten Uhd ^a   Andersen, Rikke ^a   Brodin, Birger ^a   Frokjaer, Sven ^a   Steffansen, Bente ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Aqueous stability; Dipeptide model prodrugs; hPepT1; In vitro metabolism; QSAR

Indexed keywords

BUFFER; CARRIER PROTEIN; DEXTRO ASPARTYLALANINE; DEXTRO GLUTAMYLALANINE; OLIGOPEPTIDE TRANSPORTER; PRODRUG; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; BLOOD PH; CATALYSIS; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG METABOLISM; DRUG STABILITY; DRUG STRUCTURE; ELECTRON TRANSPORT; HOMOGENATE; HUMAN; INTESTINE; IONIC STRENGTH; PRIORITY JOURNAL;

ALGORITHMS; ANIMALS; BUFFERS; CARRIER PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINES; KINETICS; PLASMA; PRODRUGS; SOLUBILITY; SOLUTIONS; SWINE; SYMPORTERS;

EID: 0035907176     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00233-4     Document Type: Article

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2. Is intestinal peptide transport energized by a proton gradient?
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4. Absorption of ACE inhibitors from small intestine and colon
5. Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, caco-2
6. 5′-amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter
7. Transepithelial transport of oral cephalosporins by monolayers of intestinal epithelial cell line caco-2: Specific transport systems in apical and basolateral membranes
8. Oral absorption of b-lactams by intestinal peptide transport proteins
9. Oligopeptide transporter mediated uptake and transport of D-Asp(OBzl)-Ala, D-Glu(OBzl)-Ala, and D-Ser(Bzl)-Ala in filter-grown Caco-2 monolayers
10. Beta-carboxylic acid esterified D-Asp-Ala retains a high affinity for the oligopeptide transporter in Caco-2 monolayers
11. Influence of oligopeptide transporter binding affinity upon uptake and transport of D-Asp(OBzl)-Ala and Asp(OBzl)-Sar in filter-grown Caco-2 monolayers
12. Stability, metabolism and transport of D-asp(obzl)-ala - A model prodrug with affinity for the oligopeptide transporter
13. Stability and in vitro metabolism of dipeptide model prodrugs with affinity for the oligopeptide transporter
14. Aqueous stability and affinity to hPepT1 in Caco-2 cells of model prodrugs with D-Glu-Ala as promoiety
15. Synthesis and application of dipeptides as drug carriers
16. Chemical pathways of peptide degradation. III. Effect of primary sequence on the pathways of deamidation of asparaginyl residues in hexapeptides
17. Metabolism, uptake, and transepithelial transport of the stereoisomers of Val-Val-Val in the human intestinal cell line, Caco-2