Bronchodilatory and anti-inflammatory properties of inhaled selective phosphodiesterase inhibitors in a guinea pig model of allergic asthma

European Journal of Pharmacology

Volumn 429, Issue 1-3, 2001, Pages 335-344

  Santing, Ruud E ^a   De Boer, Jacob ^a   Rohof, Astrid ^a   Van Der Zee, Nienke M ^a   Zaagsma, Johan ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Airway hyperreactivity; Allergic asthma; Anti inflammatory property; Bronchodilatory property; Phosphodiesterase inhibitor

Indexed keywords

6 (5,6 DIMETHOXYBENZO[B]THIEN 2 YL) 4,5 DIHYDRO 5 METHYL 3(2H) PYRIDAZINONE; ALLERGEN; HISTAMINE; N HYDROXY 4 (3,4 DIMETHOXYPHENYL)THIAZOLE 2 CARBOXIMIDAMIDE; OVALBUMIN; PEROXIDASE; PHOSPHODIESTERASE INHIBITOR; ROLIPRAM; UNCLASSIFIED DRUG;

AEROSOL; ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRONCHODILATATION; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; CELL INFILTRATION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; ENZYME ACTIVITY; EOSINOPHIL; GUINEA PIG; INHIBITION KINETICS; LUNG LAVAGE; LYMPHOCYTE; MACROPHAGE; NEBULIZER; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; PROTECTION; PROVOCATION TEST; SENSITIZATION;

ADMINISTRATION, INHALATION; ALLERGENS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHOCONSTRICTION; BRONCHODILATOR AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HISTAMINE; INFLAMMATION; OVALBUMIN; PHOSPHODIESTERASE INHIBITORS;

EID: 0035840817     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01333-4     Document Type: Article

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