Despite activation of EGF-receptor-ERK signaling pathway, epithelial proliferation is impaired in portal hypertensive gastric mucosa: Relevance of MKP-1, c-fos, c-myc, and cyclin D1 expression

Life Sciences

Volumn 69, Issue 25-26, 2001, Pages 3019-3033

  Kawanaka, Hirofumi ^a,b,c   Tomikawa, Morimasa ^c   Baatar, Dolgor ^a,b   Jones, Michael K ^a,b   Pai, Rama ^a,b   Szabo, Imre L ^a,b   Sugimachi, Keizo ^c   James Sarfeh, I ^a,b   Tarnawski, Andrzej S ^a,b  

^a VA LONG BEACH HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

c fos; c myc; Cyclin D1; Epidermal growth factor receptor; Extracellular signal regulated kinase; Gastric epithelial proliferation; Mitogen activated protein kinase phosphatase 1; Portal hypertensive gastropathy

Indexed keywords

CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR; M PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 2; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIUM CELL; GENE OVEREXPRESSION; NONHUMAN; ONCOGENE C FOS; ONCOGENE C MYC; PHOSPHORYLATION; PORTAL HYPERTENSION; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; STOMACH MUCOSA;

ANIMALS; CELL CYCLE PROTEINS; CELL DIVISION; CYCLIN D1; DISEASE MODELS, ANIMAL; DNA PRIMERS; DNA-BINDING PROTEINS; EPITHELIAL CELLS; GASTRIC MUCOSA; HYPERTENSION, PORTAL; IMMEDIATE-EARLY PROTEINS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-MYC; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, EPIDERMAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UP-REGULATION;

EID: 0035834282     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)01409-6     Document Type: Conference Paper

References (62)

1. Results of surgical management of hemorrhagic gastritis in patients with gastroesophageal varices
2. Natural history of congestive gastropathy in cirrhosis
3. Portal hypertension and gastric mucosal injury in rats. Effects of alcohol
4. The portal hypertensive gastric mucosa: Histologic, ultrastructual, and functional analysis after aspirin induced damage
5. Delayed healing of acetic-acid-induced gastric ulcer in portal hypertensive rats
6. Regulation of gastrointestinal mucosal growth
7. Cellular mechanisms of gastric ulcer healing
8. Gastric ulceration
9. The role of epidermal growth factor (EGF) and its receptor in mucosal protection, adaptation to injury, and ulcer healing: Involvement of EGF-R signal transduction pathways
10. Gastrointestinal mucosal regeneration: Role of growth factors
11. Increased expression of epidermal growth factor during gastric ulcer healing in rats
12. Epidermal growth factor and transforming growth factor-α: Role in protection and healing of gastric mucosal lesions
13. Regulation of signal transduction and signal diversity by receptor oligomerization
14. Dimerization of cell surface receptors in signal transduction
15. Signal transduction via the MAP kinases: Proceed at your own RSK
16. Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in human fibroblasts
17. 2
18. The stress-activated protein kinase subfamily of c-jun kinases
19. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
20. Induction of mitogen-activated protein kinase signal transduction pathway during gastric ulcer healing in rats
21. JNK1: A protein kinase stimulated by UV light and Ha-ras that binds and phosphorylates the c-jun activation domain
22. Transcriptional regulation by extracellular signals: Mechanisms and specificity
23. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway
24. Regulation of cyclin D1 expression and cell cycle progression by mitogen-activated protein kinase cascade
25. The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G1 phase progression in proliferating hepatocytes
26. Sequential protooncogene expression during regeneration in rat stomach
27. Expression of protooncogenes c-fos and c-myc in healing of gastric mucosal stress ulcers
28. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo
29. The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase
30. Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress
31. Correlation between sustained c-jun N-terminal protein kinase activation and apoptosis induced by tumor necrosis factor-α in rat mesangial cells
32. Portal hyperensive gastric mucosa has reduced activation of MAP Kinase (ERK2) in response to alcohol injury: A key to impaired healing?
33. Single-step method of RNA isolation by acid guanidine thiocyanate-phenol-chloroform extraction
34. The polymerase chain reaction
35. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase
36. Overexpressed nitric oxide synthase in portal-hypertensive stomach of rats: A key to increased susceptibility to damage?
37. EGF receptor mRNA and protein in rat lacrimal acinar cells: Evidence of its EGF-dependent phosphotyrosilation
38. Mitogen-activated protein kinase phosphatase 1 is overexpressed in prostate cancers and is inversely related to apoptosis
39. Suppression of cyclin D1 mRNA expression by the angiogenesis inhibitor TNP-470 (AGM-1470) in vascular endothelial cells
40. The nucleotide sequence of the rat cytoplasmic beta-actin gene
41. Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranes
42. Enhanced polymer one-step staining (EPOS) for proliferating cell nuclear antigen (PCNA) and Ki-67 antigen: Application to intra-operative frozen diagnosis
43. Cell cycle-dependent variations in the distribution of the nuclear protein cyclin proliferating cell nuclear antigen in cultured cells: Subdivision of S phase
44. Proliferating cell nuclear antigen expression in normal, preneoplastic, and neoplastic colonic epithelium of the rat
45. The effect of portal hypertension on gastric epithelial proliferation in rats
46. The role of nitric oxide in the inhibition of gastric epithelial proliferation in portal hypertensive rats
47. The effect of portal hypertension on transforming growth factor-alpha and epidermal growth factor receptor in the gastric mucosa of rats
48. The many roads that lead to Ras
49. SH2/SH3 signaling proteins
50. Activation of Raf-1 during experimental gastric ulcer healing is Ras-mediated and protein kinase C-independent
51. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
52. Protein kinases and phosphatases: The Yin and Yan of protein phosphorylation and signaling
53. Translocation of MAP (Erk-1 and -2) kinases to cell nuclei and activation of c-fos gene during healing of experimental gastric ulcers
54. Increased oxygen free radicals, nitrotyrosine and enhanced lipid peroxidation in portal hypertensive gastric mucosa: A key to increased susceptibility to injury
55. Gastropathy and defense mechanisms in common bile duct ligated portal hypertensive rats
56. Tumor necrosis factor α regulates nitric oxide synthase expression in portal hypertensive gastric mucosa of rats
57. 2 redox stress
58. Ultraviolet light and osmotic stress: Activation of JNK cascade through multiple growth factor and cytokine receptors
59. Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway
60. The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic
61. Requirement of the MAP kinase cascade for cell cycle progression and differentiation of human intestinal cells
62. Constitutive MAP kinase phosphatase (MKP-1) expression blocks G1 specific gene transcription and S-phase entry in fibroblasts