The Effect of Portal Hypertension on Transforming Growth Factor-α and Epidermal Growth Factor Receptor in the Gastric Mucosa of Rats

International Surgery

Volumn 83, Issue 3, 1998, Pages 220-223

  Wang, J Y ^a   Hsieh, J S ^a   Huang, T J ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Epidermal growth factor receptor; Portal hypertension; Transforming growth factor

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL; ARTICLE; CYTOLOGY; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; PORTAL HYPERTENSION; RAT; STOMACH MUCOSA; WISTAR RAT;

ANIMALS; GASTRIC MUCOSA; HYPERTENSION, PORTAL; IMMUNOHISTOCHEMISTRY; MALE; RATS; RATS, WISTAR; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 0032106564     PISSN: 00208868     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. McCormack TT, Sims J, Eyre-Brook I, Kennedy H, Goepel J, Johnson AG et al. Gastric lesion in portal hypertension: Inflammatory gastritis or congestive gastritis? Gut 1985;26:1226-32.
2. Papazian A, Braillon A, Dupas JL, Sevenet F, Capron JP. Portal hypertensive gastric mucosa: an endoscopic study. Gut 1986;27:1199-203.
3. Phelps TO, Mullane JF. Portal hypertension and gastric lesions in the rats. Arch Surg 1976;111:190-4.
4. Teres J, Bordas JM, Bru C, Diaz F, Bruguera M, Rodes J. Upper gastrointestinal bleeding in cirrhosis: clinical and endoscopic correlations. Gut 1976;17:37-40.
5. Franco D, Durandy Y, Deporte A, Bismuth H. Upper gastrointestinal haemorrhage in hepatic cirrhosis: causes and relation to hepatic failure and stress. Lancet 1977;1::218-20.
6. Sarfeh IJ, Tarnwski A, Malki A, Mason GR, Mach T, Ivey KJ. Portal hypertension and gastric mucosal injury in rats. Effects of alcohol. Gastroenterology 1983;84:987-93.
7. Wang JY, Hsieh JS, Huang TI. Changes in rat gastric mucosal glycoproteins in portal hypertension. Eur Surg Res 1997;29:280-6.
8. Marquardt H, Hunkapiller MM, Hood LE, Todaro GJ. Rat transforming growth factor type 1: structure and relation to epidermal growth factor. Science 1984;223:1079-82.
9. Derynck R, Roberts AB, Winkler ME, Chen EY, Goeddel DV. Human transforming growth factor α: precursor structure and expression in E. coli. Cell 1984;38:287-97.
10. Beauchamp RD, Barnard JA, McCutchen CM, Cherner JA, Coffey RJ. Localization of TGF alpha and its receptor in gastric mucosal cells: implication for a regulatory role in acid secretion and mucosal renewal. J Clin Invest 1990;84:1017-23.
11. Cohen S, Ushiro H, Stoscheck C, Chinkers M. A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles. J Biol Chem 1982;257:1523-31.
12. Chen WS, Lazar CS, Poenie M, Tsien RY, Gill GN, Rosenfeld MG. Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor. Nature 1987;328:820-3.
13. Lee H, Hansson HA, Norstrom E, Helander HF. Immunoreactivities for epidermal growth factor (EGF) and for EGF receptors in rats with gastric ulcer. Cell Tissue Res 1991;265:211-8.
14. Polk WH, Dempsey PJ, Russel WE, Brown PI, Beauchamp RD, Barnard JA et al. Increased production of transforming growth factor α following acute gastric injury. Gastroenterology 1992;102:1467-74.
15. Tarnwski A, Stachura J, Durbin T, Sarfeh IJ, Gergely H. Increased expression of epidermal growth factor receptor during gastric ulcer healing in rats. Gastroenterology 1992;102:695-8.
16. Hsieh JS, Huang TJ. The effect of portal hypertension on gastric epithelial proliferation in rats. Eur Surg Res 1993;25:98-103.
17. Sarfeh IJ, Tarnwski A. Gastric mucosal vasculopathy in portal hypertension. Gastroenterology 1987;93:1129-31.
18. Romano M, Polk WH, Award JA, Arteaga CL, Nanney LB, Wargovich MJ et al. Transforming growth factor α protection against drug-induced injury to the rat gastric mucosa in vivo. J Clin Invest 1992;90:2409-21.
19. Konturek SJ, Brzozowski T, Majka J, Dembinski A, Slomiany A, Slomiany BL. Transforming growth factor α and epidermal growth factor in protection and healing of gastric mucosal injury. Scand J Gastroenterol 1992;27:649-55.
20. Johnson LR, Guthrie PD. Stimulation of rat oxyntic gland mucosal growth by epidermal growth factor. Am J Physiol 1980;238:G45-9.
21. Chen MC, Lee AT, Karnes WE, Avedian D, Martin M, Sorvillo JM et al. Paracrine control of gastric epithelial cell growth in culture by transforming growth factor-α. Am J Physiol 1993;264:390-6.
22. Abe S, Sasano H, Katoh K, Ohara S, Arikawa T, Noguchi T et al. Immunohistochemical studies on EFG family growth factors in normal and ulcerated human gastric mucosa. Dig Dis Sci 1997;42:1199-209.