Rational design of synthetic enzymes and their potential utility as human pharmaceuticals: Development of manganese(II)-based Superoxide dismutase mimics

CATTECH

Volumn 1, Issue 1, 1997, Pages 41-49

  Riley, Dennis P ^a   Weiss, Randy H ^a  

^a MONSANTO COMPANY   (United States)

Author keywords

Catalyst; Manganese(II) complexes; Pharmaceuticals; SOD; Superoxide; Synzymes

Indexed keywords

EID: 0003504041     PISSN: 13846566     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Article

References (7)

1. a) 1. M. McCord, I. Fridovich, J Biol Chem, 244, (1969) 6049.
2. b) I. Fridovich, J. Biol. Chem., 264, (1989) 7761.
3. [2) S. W. Werns, P. J. Simpson, J. K. Mickelson, M. J. Shea, B. Pitt. B. R. Lucchesi, J Cardiovasc. Pharniacol., 11, (1988) 36.
4. J. K. McCord, J. Free Radicals Biol. Med., 2, ( 1986) 307.
5. Y. Oyanagui, Biochem Phannacol, 25, (1976) 1465.
6. M. T. Droy-Lefaix, Y. Drouct, G. Geraud, D. Hosford, P. Braquet, Free Radical Res Commun, 12-13, (1991) 725.
7. M. Shingu, S. Takahashi, M. Ito, N.Hamamatu, Y. Suenaga, Y. Ichibangase, M. Nobunaga, Rheumatol Int., 14, (1994) 77.