Ethanol enhances the formation of endogenously and exogenously derived adducts in rat hepatic DNA

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 479, Issue 1-2, 2001, Pages 81-94

  Navasumrit, P ^a,c   Ward, T H ^a   O'Connor, P J ^a   Nair, J ^b   Frank, N ^b   Bartsch, H ^b  

^a CHRISTIE HOSPITAL   (United Kingdom)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c CHULABHORN RESEARCH INSTITUTE   (Thailand)

Author keywords

CYP 2E1; Ethanol; Etheno DNA adducts; Lipid peroxidation; N nitrosodimethylamine; O6 methylguanine

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O METHYLGUANINE; ALCOHOL; ALKYLATING AGENT; CYTOCHROME P450 2E1; DEOXYADENOSINE; DEOXYCYTIDINE; DEOXYETHENOCYTIDINE; DIMETHYLNITROSAMINE; DNA; ETHENODEOXYADENOSINE; FREE RADICAL; UNCLASSIFIED DRUG;

ALCOHOL BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CELL NUCLEUS; CHEMICAL CARCINOGENESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET; DNA ADDUCT; DNA DAMAGE; DNA STRAND BREAKAGE; DOSE RESPONSE; ENZYME ACTIVITY; EXPOSURE; IMMUNOHISTOCHEMISTRY; KIDNEY CELL; LIPID PEROXIDATION; LIVER; LIVER CELL; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ALKYLATING AGENTS; ANIMALS; BINDING, COMPETITIVE; BLOTTING, WESTERN; CARCINOGENS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHROMATOGRAPHY, THIN LAYER; CYTOCHROME P-450 CYP2E1; DEOXYADENOSINES; DEOXYCYTIDINE; DNA ADDUCTS; DNA DAMAGE; ETHANOL; GUANINE; IMMUNOHISTOCHEMISTRY; LIVER; MALE; MICE; MUTAGENS; NITROSO COMPOUNDS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; RATS; RATS, WISTAR; TIME FACTORS;

RATTUS NORVEGICUS;

EID: 0035828182     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(01)00156-7     Document Type: Article

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