1,N6-Ethenoadenine and 3,N4-ethenocytosine are excised by separate human DNA glycosylases

Carcinogenesis

Volumn 17, Issue 1, 1996, Pages 155-157

  Hang, B ^a   Chenna, A ^a   Rao, S ^a   Singer, B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE DERIVATIVE; CHLOROACETALDEHYDE; CYTOSINE DERIVATIVE; DNA GLYCOSYLTRANSFERASE; 1,N(6) ETHENOADENINE; 1,N(6)-ETHENOADENINE; 3,N(4) ETHENOCYTOSINE; 3,N(4)-ETHENOCYTOSINE; ADENINE; CYTOSINE; DRUG DERIVATIVE; GLYCOSIDASE; MUTAGENIC AGENT;

ARTICLE; CONTROLLED STUDY; DNA ADDUCT; DNA CONFORMATION; ENZYME ACTIVITY; ENZYME PURIFICATION; ENZYME SPECIFICITY; EXCISION REPAIR; FAST PROTEIN LIQUID CHROMATOGRAPHY; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PURIFICATION; DNA REPAIR; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE;

ADENINE; BASE SEQUENCE; CYTOSINE; DNA GLYCOSYLASES; DNA REPAIR; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENS; N-GLYCOSYL HYDROLASES;

EID: 0029664670     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.1.155     Document Type: Article

References (28)

1. Lindahl.T. (1982) DNA repair enzymes. Annu. Rev. Biochem., 51, 61-87.
2. Sancar,A. and Sancar,G.B. (1988) DNA repair enzymes. Annu. Rev. Biochem., 57, 29-67.
3. 6-ethenoadenine in a DNA fragment. Proc. Natl Acad. Sci. USA, 88, 6839-6842.
4. 6-ethenodeoxyadenosine. Cancer Res., 52, 1377-1379.
5. 6-ethenoadenine and 3-methyladenine. Proc. Natl Acad. Sci. USA, 89, 9386-9390.
6. 6-ethenoadenine is preferred over 3-methyladenine as substrate by a cloned human N-methylpurine-DNA glycosylase (3-methyladenine-DNA glycosylase). Biochemistry, 33, 1624-1628.
7. Dosanjh,M.K., Chenna,A., Kim,E., Fraenkel-Conrat,H., Samson,L. and Singer,B. (1994) All four known cyclic adducts formed in DNA by the vinyl chloride metabolite chloroacetaldehyde are released by a human DNA glycosylase. Proc. Natl Acad. Sci. USA, 91, 1024-1028.
8. Chenna,A., Hang,B., Rydberg,B., Kim,E., Bodell,W.J., Pongracz,K. and Singer,B. (1995) The benzene metabolite p-benzoquinone forms adducts with DNA bases that are excised by a repair activity from human cells that differs from an ethenoadenine glycosylase. Proc. Natl Acad. Sci. USA, 92, 5890-5894.
9. Singer,B., Spengler,S.J. and Kuśmierek,J.T. (1988) Reactions of vinyl chloride and its metabolites with bases in nucleic acids and the potential biological consequences. In Politzer,P.A. and Martin,F. (eds). Chemical Carcinogens: Activation Mechanisms, Structural and Electronic Factors, and Reactivity. Elsevier Science Publishes, Amsterdam, The Netherlands, pp. 188-207.
10. Leonard,N.J. (1992) Etheno-bridged nucleotides in structural diagnosis and carcinogenesis. Biochem. Mol. Biol. Chemtracts, 3, 273-297.
11. 2-ethenodeoxyguanosine: synthesis, properties and formation in DNA. Chem. Res. Toxicol., 5, 634-638.
12. Swenberg,J.A., Fedtke,N., Fennell,T.R. and Walker,VE. (1990) Relationships between carcinogen exposure, DNA adducts, and carcinogenesis. In Clayson,D.B., Munro,I.C., Shubik,P. and Swenberg,J.A. (eds), Progress in Predictive Toxicology. Elsevier/North Holland Biomedical Press, Amsterdam. The Netherlands, pp. 161-184.
13. Miller, J.A. (1994) Recent studies on the metabolic activation of chemical carcinogens. Cancer Res., 54 (Suppl. 7), 1879-1881.
14. 32P-postlabeling. Carcinogenesis, 16, 613-617.
15. Barbin,A. and Bartsch,H. (1986) Mutagenic and promutagenic properties of DNA adducts formed by vinyl chloride metabolites. In Singer,B. and Bartsch,H. (eds), The Role of Cyclic and Nucleic Acid Adducts in Carcinogenesis and Mutagenesis. IARC Scientific Publication no. 70, Oxford University Press, New York, NY, pp. 345-358.
16. Singer,B. and Spengler,S.J. (1986) Replication and transcription of polynucleotides containing ethenocytosine, ethenoadenine and their hydrated intermediates. In Singer,B. and Bartsch,H. (eds), The Role of Cyclic and Nucleic Acid Adducts in Carcinogenesis and Mutagenesis. IARC Scientific Publication no. 70, Oxford University Press, New York, NY, pp. 359-371.
17. 4-methyldeoxythymidine, using polymerases of varying fidelity, Carcinogenesis, 5, 1165-1171.
18. 2,3-ethenodeoxyguanosine, using a site-directed kinetic study. Carcinogenesis, 12, 745-747.
19. 4-ethano-2′-deoxycytidine, and 3-(2-hydroxyethyl)-2′-deoxyuridine. Chem. Res. Toxicol., 8, 157-163.
20. Palejwala,V.A., Rzepka,R.W., Simha,D. and Humayun,M.Z. (1993) Quantitative multiplex sequence analysis of mutational hot spots. Frequency and specificity of mutations induced by a site-specific ethenocytosine in M13 viral DNA. Biochemistry, 32, 4105-4111.
21. 4-ethenocytosine and 4-amino-5-(imidazol-2-yl)imidazole. Biochemistry, 32. 12793-12801.
22. 2,3-ethenoguanosine, is a highly efficient mutagen in transcription. Carcinogenesis, 8, 745-747.
23. 2,3-ethenoguanosine, produces G→A transitions in E. coli. Proc. Natl Acad. Sci. USA, 88, 9974-9978.
24. Oesch,F. Adler,S., Rettelbach,R. and Doerjer,G. (1986) Repair of etheno DNA adducts by N-glycosylases. In Singer,B. and Bartsch,H. (eds), The Role of Cyclic and Nucleic Acid Adducts in Carcinogenesis and Mutagenesis. IARC Scientific Publication no. 70, Oxford University Press, New York, NY, pp. 373-379.
25. Saparbaev,M. and Laval,J. (1994) Excision of hypoxanthine from DNA containing dIMP residues by the Escherichia coli, yeast, rat. and human alkylpurine DNA glycosylases. Proc. Natl Acad. Sci. USA, 91, 5873-5877.
26. O'Connor,T.R. and Laval,J. (1991) Human cDNA expressing a functional DNA glycosylase excising 3-methyladenine and 7-methylguanine. Biochem. Biophys. Res. Commun., 176, 1170-1177.
27. Chakravarti,D., Ibeanu,G.C., Tano,K. and Mitra,S. (1991) Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase. J. Biol. Chem., 266, 15710-15715.
28. Demple,B. and Harrison,L. (1994) Repair of oxidative damage to DNA: enzymology and biology. Annu. Rev. Biochem., 63, 915-948.