Potentiation of arsenic-induced cytotoxicity by sulfur amino acid deprivation (SAAD) through activation of ERK1/2, p38 kinase and JNK1: The distinct role of JNK1 in SAAD-potentiated mercury toxicity

Toxicology Letters

Volumn 121, Issue 1, 2001, Pages 45-55

  Son, Moon Ho ^a,b   Kang, Keon Wook ^a   Lee, Chang Ho ^c   Kim, Sang Geon ^a  

^a Seoul National University   (South Korea)

^b Dong A Pharmaceutical Company   (South Korea)

^c Hanyang University   (South Korea)

Author keywords

Arsenic; Cytotoxicity; ERK; Heavy metals; JNK; MAP kinase; Mercury; p38 Kinase; Sulfur amino acid

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ARSENITE SODIUM; CHROMIUM DERIVATIVE; CHROMIUM TRIOXIDE; HEAVY METAL; LEAD ACETATE; MANGANESE CHLORIDE; MERCURIC CHLORIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; SODIUM SELENITE; STRESS ACTIVATED PROTEIN KINASE; SULFUR AMINO ACID; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL LINE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; HEPATOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

AMINO ACIDS, SULFUR; ANIMALS; ARSENIC; CELL SURVIVAL; ENZYME ACTIVATION; IN SITU NICK-END LABELING; MERCURY; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; POISONS; RATS; SIGNAL TRANSDUCTION; TETRAZOLIUM SALTS; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 0035826502     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(01)00314-9     Document Type: Article

References (36)

1. Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats
2. Low levels of arsenic trioxide stimulate proliferative signals in primary vascular cells without activating stress effector pathways
3. Molecular aspects of arsenic stress
4. Intracellular effects of chronic arsenic administration on renal proximal tubule cells
5. The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase
6. Protective roles of metallothionein and glutathione in hepatotoxicity of cadmium
7. Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium
8. Prevention of c-Jun/activator protein-1 activation and microsomal epoxide hydrolase induction in the rat liver by cysteine during protein-calorie malnutrition
9. The effect of cysteine on the altered expression of class alpha and mu: Glutathione S-transferase genes in the rat liver during protein-calorie malnutrition
10. Alterations of lipid synthesis in the normal and dysmyelinating trembler mouse sciatic nerve by heavy metals (Hg, Pb, Mn, Cu, Ni)
11. Specificity and mechanism of action of some commonly used protein kinase inhibitors
12. 2+ is mediated by MKK7
13. Changes in hepatic glutathione concentration modify cadmium-induced hepatotoxicity
14. Effects of sulfhydryl compounds on the accumulation, removal and cytotoxicity of inorganic mercury by primary cultures of rat renal cortical epithelial cells
15. 2-terminal kinase-dependent, p53-independent pathway
16. The essential role of phosphatidylinositol 3-kinase and of p38 mitogen-activated protein kinase activation in the antioxidant response element-mediated rGSTA2 induction by decreased glutathione in H4IIE hepatoma cells
17. DA-125, a novel anthracycline derivative with high affinity DNA binding and topoisomerase II inhibitory activities, exerts cytotoxicity via c-Jun N-terminal kinase pathway
18. Role of metallothionein in cadmium-induced hepatotoxicity and nephrotoxicity
19. Effect of selenium on aflatoxin hepatocarcinogenesis in the rat
20. Glutathione can rescue the inhibitory effects of nickel on DNA ligation and repair synthesis
21. Mercury chloride activates c-Jun N-terminal kinase and induces c-jun expression in LLC-PK1 cells
22. Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase
23. Long-term effects of childhood exposure to lead at low dose; an eleven-year follow up report
24. Metal toxicity and the respiratory tract
25. The toxic level of sodium selenite in the diet of laying chickens
26. Low-level methylmercury exposure causes human T-cells to undergo apoptosis: Evidence of mitochondrial dysfunction
27. Mercury-induced apoptosis in human lymphoid cells: Evidence that the apoptotic pathway is mercurial species dependent
28. Influence of cadmium chloride, mercuric chloride, and sodium vanadate on the glutathione-conjugating enzyme system in liver, kidney, and brain of mice
29. Toxicological significance of metallothionein
30. Activation of ERK1 and ERK2 is required for manganese-induced neurite outgrowth in rat pheochromocytoma (PC12) cells
31. Arsenite induces apoptosis in Chinese hamster ovary cells by generation of reactive oxygen species
32. Activation of the EGF receptor signaling pathway in human airway epithelial cells exposed to metals
33. Cellular defenses against damage from reactive oxygen species