DA-125, a novel anthracycline derivative showing high-affinity DNA binding and topoisomerase II inhibitory activities, exerts cytotoxicity via c-Jun N-terminal kinase pathway

Cancer Chemotherapy and Pharmacology

Volumn 47, Issue 6, 2001, Pages 511-518

  Kim, Sang Geon ^a   Sung, Mina ^a   Kang, Keon Wook ^a   Kim, Soon Hoe ^b   Son, Moon Ho ^a,b   Kim, Won Bae ^b  

^a Seoul National University   (South Korea)

^b Dong A Pharmaceutical Company   (South Korea)

Author keywords

Apoptosis; Chemotherapy; DA 125; DNA binding; Doxorubicin; JNK; Topoisomerase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRACYCLINE DERIVATIVE; ANTINEOPLASTIC AGENT; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; GALARUBICIN; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CHEMOTHERAPY; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DRUG DNA BINDING; ENZYME ACTIVATION; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; BETA-ALANINE; CARCINOMA, HEPATOCELLULAR; DNA TOPOISOMERASES, TYPE II; DNA, NEOPLASM; DOXORUBICIN; ENZYME INHIBITORS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER NEOPLASMS; MITOGEN-ACTIVATED PROTEIN KINASES; PEROXIDASE; RATS; TUMOR CELLS, CULTURED;

EID: 0035021627     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800100276     Document Type: Article

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