Mercury chloride activates c-Jun N-terminal kinase and induces c-Jun expression in LLC-PK1 cells

Toxicological Sciences

Volumn 53, Issue 2, 2000, Pages 361-368

  Matsuoka, Masato ^a   Wispriyono, Bambang ^a   Iryo, Yoshihisa ^a   Igisu, Hideki ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

c jun; c Jun N terminal kinase; c Jun protein; LLC PK1 cells; Mercury chloride; Nephrotoxicity

Indexed keywords

CADMIUM CHLORIDE; CALCIUM ION; LEAD CHLORIDE; MANGANESE CHLORIDE; MERCURY CHLORIDE; MESSENGER RNA; STRESS ACTIVATED PROTEIN KINASE; THIOL GROUP; ZINC CHLORIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; IMMUNOBLOTTING; NEPHROTOXICITY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SWINE;

EID: 0033977886     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/53.2.361     Document Type: Article

References (36)

1. 19F-NMR spectroscopy. Biochem. J. 322, 793-799.
2. Bossy-Wetzel, E., Bakiri, L., and Yaniv, M. (1997). Induction of apoptosis by the transcription factor c-Jun. EMBO J. 16, 1695-1709.
3. Cavigelli, M., Dolfi, F., Claret, F.-X., and Karin, M. (1995). Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation. EMBO J. 14, 5957-5964.
4. Chen, Y.-R., Wang, X., Templeton, D., Davis, R. J., and Tan, T.-H. (1996). The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and y radiation. Duration of JNK activation may determine cell death and proliferation. J. Biol. Chem. 271, 31929-31936.
5. Chung, H.-O., Kato, T., and Kato, Y. (1996). Molecular cloning of c-jun and c-fos cDNAs from porcine anterior pituitary and their involvement in gonadotropin-releasing hormone stimulation. Mol. Cell. Endocrinol. 119, 75-82.
6. Clarkson, T. W. (1997). The toxicology of mercury. CRC Crit. Rev. Clin. Lab. Sci. 34, 369-403.
7. 1. J. Pharmacol. Exp. Ther. 277, 1726-1732.
8. Dérijard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M., and Davis, R. J. (1994). JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76, 1025-1037.
9. Eilers, A., Whitfield, J., Babij, C., Rubin, L. L., and Ham, J. (1998). Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons. J. Neurosci. 18, 1713-1724.
10. 2-terminal kinase activation and c-Jun in the induction of apoptosis by the ether phospholipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine. Mol. Pharmacol. 53, 602-612.
11. Gstraunthaler, G. J. A. (1988). Epithelial cells in tissue culture. Renal Physiol. Biochem. 11, 1-42.
12. Guo, Y.-L., Baysal, K., Kang, B., Yang, L.-J., and Williamson, J. R. (1998). Correlation between sustained c-Jun N-terminal protein kinase activation and apoptosis induced by tumor necrosis factor-α in rat mesangial cells. J. Biol. Chem. 273, 4027-4034.
13. Hibi, M., Lin, A., Smeal, T., Minden, A., and Karin, M. (1993). Identification of an oncoprotein-and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7, 2135-2148.
14. Hirata, Y., Adachi, K., and Kiuchi, K. (1998). Activation of JNK pathway and induction of apoptosis by manganese in PC12 cells. J. Neurochem. 71, 1607-1615.
15. Karin, M. (1995). The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270, 16483-16486.
16. Kyriakis, J. M., and Avruch, J. (1996). Sounding the alarm: protein kinase cascades activated by stress and inflammation. J. Biol. Chem. 271, 24313-24316.
17. Kyriakis, J. M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruch, J., and Woodgett, J. R. (1994). The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369, 156-160.
18. Lieberthal, W., and Levine, J. S. (1996). Mechanisms of apoptosis and its potential role in renal tubular epithelial cell injury. Am. J. Physiol. 271, F477-F488.
19. Marais, R., Wynne, J., and Treisman, R. (1993). The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73, 381-393.
20. 1 cells by cadmium. Biochem. Biophys. Res. Commun. 251, 527-532.
21. 1 cells. Chem.-Biol. Interact. 108, 95-106.
22. Mitchell, F. M., Russell, M., and Johnson, G. L. (1995). Differential calcium dependence in the activation of c-Jun kinase and mitogen-activated protein kinase by muscarinic acetylcholine receptors in rat 1a cells. Biochem, J. 309, 381-384.
23. Nath, K. A., Croatt, A. J., Likely, S., Behrens, T. W., and Warden, D. (1996). Renal oxidant injury and oxidant response induced by mercury. Kidney Int. 50, 1032-1043.
24. Preston, G. A., Lyon, T. T., Yin, Y., Lang, J. E., Solomon, G., Annab, L., Srinivasan, D. G., Alcorta, D. A., and Barrett, J. C. (1996). Induction of apoptosis by c-Fos protein. Mol. Cell. Biol. 16, 211-218.
25. Ramesh, G. T., Manna, S. K., Aggarwal, B. B., and Jadhav, A. L. (1999). Lead activates nuclear transcription factor-κB, activator protein-1, and amino-terminal c-Jun kinase in pheochromocytoma cells. Toxicol. Appl. Pharmacol. 155, 280-286.
26. Rosenspire, A. J., Bodepudi, S., Mathews, M., and McCabe, M. J., Jr. (1998). Low levels of ionic mercury modulate protein tyrosine phosphorylation in lymphocytes. Int. J. Immunopharmacol. 20, 697-707.
27. Samet, J. M., Graves, L. M., Quay, J., Dailey, L. A., Devlin, R. B., Ohio, A. J., Wu, W., Bromberg, P. A., and Reed, W. (1998). Activation of MAPKs in human bronchial epithelial cells exposed to metals. Am. J. Physiol. 275, L551-L558.
28. Schaeffer, H. J., and Weber, M. J. (1999). Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol. Cell. Biol. 19, 2435-2444.
29. 2+ of cultured rabbit renal tubular cells. Biochim. Biophys. Acta. 931, 130-142.
30. Templeton, D. M. (1990). Cadmium uptake by cells of renal origin. J. Biol. Chem. 265, 21764-21770.
31. Tietze, F. (1969). Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal. Biochem. 27, 502-522.
32. van Dam, H., Duyndam, M., Rottier, R., Bosch, A., de Vries-Smits, L., Herrlich, P., Zantema, A., Angel, P., and van der Eb, A. J. (1993). Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein. EMBO J. 12, 479-487.
33. van Dam, H., Wilhelm, D., Herr, I., Steffen, A., Herrlich, P., and Angel, P. (1995). ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J. 14, 1798-1811.
34. Verheij, M., Bose, R., Lin, X. H., Yao, B., Jarvis, W. D., Grant, S., Birrer, M. J., Szabo, E., Zon, L. I., Kyriakis, J. M., Haimovitz-Friedman, A., Fuks, Z., and Kolesnick, R. N. (1996). Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380, 75-79.
35. 1 cells. J. Pharmacol Exp. Ther. 287, 344-351.
36. Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., and Greenberg, M. E. (1995). Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331.