Synthesis of trans-fused [5,5] bicyclic lactones/lactams as templates for serine protease inhibition

Tetrahedron Letters

Volumn 39, Issue 38, 1998, Pages 6979-6982

  Kelly, Henry A ^a   Bolton, Richard ^a   Brown, Stuart A ^a   Coote, Steven J ^a   Dowle, Mike ^a   Dyer, Ulrich ^a   Finch, Harry ^a   Golding, Doreen ^a   Lowdon, Andrew ^a   McLaren, Jessica ^a   Montana, John G ^a   Owen, Martin R ^a   Pegg, Neil A ^a   Ross, Barry C ^a   Thomas, Rhian ^a   Walker, Dawn A ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHYMOTRYPSIN; FUSED HETEROCYCLIC RINGS; LACTAM; LACTAM DERIVATIVE; LACTONE; LACTONE DERIVATIVE; LEUKOCYTE ELASTASE; REAGENT; SERINE PROTEINASE INHIBITOR;

ARTICLE; CHEMICAL STRUCTURE; CYCLIZATION; ENZYME INACTIVATION; PROTEINASE INHIBITION; STEREOISOMERISM; SYNTHESIS;

EID: 0032541734     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01481-6     Document Type: Article

References (17)

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16. 3N, DMF, 74%; (ii) LDA, BnBr, -78 °C, THF, 12%; (iii) TBAF, 67%.
17. 10. Finch, H. manuscript in preparation.