Caspase-independent apoptosis induced by differentiation-inducing factor of Dicytostelium discoideum in INS-1 cells

European Journal of Pharmacology

Volumn 421, Issue 2, 2001, Pages 93-100

  Fujimaki, Shuku ^a,b   Kubohara, Yuzuru ^b   Kobayashi, Isao ^a   Kojima, Itaru ^b  

^a GUNMA UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Ca2+; Caspase; DIF (differentiation inducing factor); Insulin

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BENZYLOXYCARBONYLALANYLSERYLPROLYL 2,6 DICHLOROBENZOYLOXYMETHYLKETONE; CALCIUM ION; CASPASE 3; CASPASE INHIBITOR; DIFFERENTIATION INDUCING FACTOR; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL VIABILITY; CHELATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DICTYOSTELIUM DISCOIDEUM; ENZYME ACTIVATION; INSULIN RELEASE; NICK END LABELING; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; SECRETORY CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CALCIUM; CASPASE 3; CASPASES; CELL SURVIVAL; CHELATING AGENTS; EGTAZIC ACID; HEXANONES; IONOMYCIN; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0035817451     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01034-2     Document Type: Article

References (31)

1. DIF-I, morphogen of D. discoideum, induces erythroid differentiation in murine and human leukemia cells
2. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
3. Evaluation of tetrazolium-based semiautomated colorimetric assay
4. TAJ, a novel member of the tumor necrosis factor-α receptor family, activates the c-Jun-N-terminal kinase pathway and mediates caspase-independent cell death
5. Glucose and tulbutamide induce apoptosis in pancreatic β-cells
6. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
7. Enforced dimerization of Bax results in its translocation, mitochondrial dysfunction and apoptosis
8. The biochemistry of apoptosis
9. Coordinate actions of FSH and insulin-like growth factor-I on LH receptor expression in rat granulosa cells
10. A possible morphogen controlling differentiation in Dictyotelium
11. Morphogen hunting in D. discoideum
12. Caspase-dependent and independent events in apoptosis induced by hydrogen peroxide
13. Oscillation of cytoplasmic free calcium concentration induced by IGF-I
14. DIF-I, putative morphogen of D. discoideum, suppresses cell growth and promotes retinoic acid-induced cell differentiation of HL60
15. Effects of differentiation-inducing factors of D. discoideum on human leukemia K562 cells: DIF-3 is the most potent anti-leukemic agent
16. The putative morphogen, DIF-1, of D. discoideum activates Akt/PKB in human leukemia K562 cells
17. Differanisole A, an inducer of the differentiation of Friend leukemic cells, induces stalk cell differentiation in D. discoideum
18. Putative morphogen, DIF, of Dictytostelium discoideum induces apoptosis in rat pancreatic AR42J cells
19. Differentiation-inducing factor of D. discoideum raises intracellular calcium concentration and suppresses cell growth in rat pancreatic AR42J cells
20. Effects of DIF-1, an anti-tumor agent isolated from Dictyostelium discoideum, on rat gastric mucosal RGM-1 a.d. leptomeningeal cells
21. Activation of calpain I converts excitotoxic neuron death into caspase-independent cell death
22. PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond
23. Aspartate-based inhibitor of interleukin-1β-converting enzyme prevents anti-tumor agent-induced apoptosis in human myeloid leukemia U937 cells
24. Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage or the Bcl-2 homolog Bak
25. 1, arrest and differentiation of vascular smooth muscle cells
26. Differanisole A, a new differentiation inducing substance
27. Blockade of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase
28. Amyloid beta-induced neuronal death is bax-dependent but caspase-independent
29. Caspases and caspase inhibitors
30. A specific inhibitor of phosphoinositide 3-kinase, 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one (LY294002)
31. Bax-induced cell death may not require interleukin l(-converting enzyme-like proteases