Effects of differentiation-inducing factors of Dictyostelium discoideum on human leukemia K562 cells: DIF-3 is the most potent anti-leukemic agent

European Journal of Pharmacology

Volumn 381, Issue 1, 1999, Pages 57-62

  Kubohara, Yuzuru ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

Ca2+; Dictyostelium; Differentiation inducing factor; Erythroid differentiation; Growth inhibition

Indexed keywords

ALKANONE; CALCIUM; DIFFERENTIATION INDUCING FACTOR; DNA;

ARTICLE; CALCIUM CELL LEVEL; CELL DIFFERENTIATION; CELL GROWTH; DICTYOSTELIUM DISCOIDEUM; DNA SYNTHESIS; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ERYTHROID CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CALCIUM; CELL COUNT; CELL DIFFERENTIATION; CELL DIVISION; DICTYOSTELIUM; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; HEXANONES; HUMANS; K562 CELLS; LEUKEMIA; PENTANONES; PHENOLS; RESORCINOLS;

EID: 0032829310     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00548-8     Document Type: Article

References (18)

1. Asahi K., Sakurai A., Takahashi N., Kubohara Y., Okamoto K., Tanaka Y. DIF-1, morphogen of Dictyostelium discoideum, induces the erythroid differentiation in murine and human leukemia cells. Biochem. Biophys. Res. Commun. 208:1995;1036-1039.
2. 2+ in Dictyostelium discoideum. Exp. Cell Res. 230:1997;403-406.
3. Bonner J.T. Induction of stalk cell differentiation by cyclic AMP in the cellular slime mold Dictyostelium discoideum. Proc. Natl. Acad. Sci. U.S.A. 65:1970;110-113.
4. Kay R.R., Berks M., Traynor D. Morphogen hunting in Dictyostelium discoideum. Development. 1989;81-90. Suppl.
5. Kubohara Y. DIF-1, putative morphogen of D. discoideum, suppresses cell growth and promotes retinoic acid-induced cell differentiation in HL-60. Biochem. Biophys. Res. Commun. 236:1997;418-422.
6. + concentrations determine cell fate in Dictyostelium discoideum. FASEB J. 8:1994;869-874.
7. Kubohara Y., Kimura C., Tatemoto K. Putative morphogen, DIF, of Dictyostelium discoideum induces apoptosis in rat pancreatic AR42J cells. Dev. Growth Differ. 37:1995;711-716.
8. Kubohara Y., Saito Y., Tatemoto K. Differentiation-inducing factor of D. discoideum raises intracellular calcium concentration and suppresses cell growth in rat pancreatic AR42J cells. FEBS Lett. 359:1995;119-122.
9. Kubohara Y., Kabeya K., Matsui H., Ishikawa K. Effects of DIF-1, an anti-tumor agent isolated from Dictyostelium discoideum, on rat gastric mucosal RGM-1 and leptomeningeal cells. Zool. Sci. 15:1998;713-721.
10. Lozzio C.B., Lozzio B.B. Human chronic myelogenous leukemia cell line with positive Philadelphia chromosome. Blood. 45:1975;321-334.
11. Masento M.S., Morris H.R., Taylor G.W., Johnson S.J., Skapski A.C., Kay R.R. Differentiation-inducing factor from the slime mould Dictyostelium discoideum and its analogues. Biochem. J. 256:1988;23-28.
12. Morandini P., Offer J., Traynor D., Nayler O., Neuhaus D., Taylor G.W., Kay R.R. The proximal pathway of metabolism of the chlorinated signal molecule differentiation-inducing factor-1 (DIF-1) in the cellular slime mould Dictyostelium. Biochem. J. 306:1995;735-743.
13. Morris H.R., Taylor G.W., Masento M.S., Jermyn K.A., Kay R.R. Chemical structure of the morphogen differentiation inducing factor from Dictyostelium discoideum. Nature. 328:1987;811-814.
14. Morris H.R., Masento M.S., Taylor G.W., Jermyn K.A., Kay R.R. Structure elucidation of two differentiation inducing factors (DIF-2 and DIF-3) from the cellular slime mould Dictyostelium discoideum. Biochem. J. 249:1988;903-906.
15. 2+ levels mediates stalk gene induction by differentiation inducing factor in Dictyostelium. EMBO J. 15:1996;5177-5183.
16. Sutherland J.A., Turner A.R., Mannoni P., McGann L.E., Turc J.M. Differentiation of K562 leukemia cells along erythroid, macrophage, and megakaryocyte lineages. J. Biol. Response Med. 5:1986;250-262.
17. Town C.D., Gross J.D., Kay R.R. Cell differentiation without morphogenesis in Dictyostelium discoideum. Nature. 262:1976;717-719.
18. Wurster B., Kay R.R. New roles for DIF? Effects on early development in Dictyostelium. Dev. Biol. 140:1990;189-195.