The effects of the antihormones RU486 and tamoxifen on fetoplacental development and placental bed vascularisation in the rat: A model for intrauterine fetal growth retardation

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 103, Issue 7, 1996, Pages 630-641

  Sadek, Saher ^a   Bell, Stephen C ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MIFEPRISTONE; TAMOXIFEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; FETUS; FETUS DEATH; FETUS DEVELOPMENT; INTRAUTERINE GROWTH RETARDATION; NONHUMAN; PLACENTA CIRCULATION; PLACENTA DEVELOPMENT; PRIORITY JOURNAL; RAT; SIDE EFFECT; VASCULARIZATION;

ABORTIFACIENT AGENTS, STEROIDAL; ANIMALS; BODY WEIGHT; EMBRYO IMPLANTATION; EMBRYONIC AND FETAL DEVELOPMENT; ESTROGEN ANTAGONISTS; FEMALE; IMMUNOHISTOCHEMISTRY; MIFEPRISTONE; PLACENTA; PREGNANCY; RATS; RATS, WISTAR; TAMOXIFEN;

EID: 0029986230     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.1996.tb09830.x     Document Type: Article

References (41)

1. Robertson WB, Brosens I, Landells WN. Abnormal placentation. Obster Gynecol Ann 1985; 14: 411-426.
2. Pijnenborg R. Trophoblast invasion and placentation in the human: morphological aspects. Troph Res 1990; 4: 33-47.
3. Brosens I, Robertson WB, Dixon HG. The physiological response of the vessels of the placental bed to normal pregnancy. J Path Bact 1967; 93: 569-579.
4. Brosens I, Dixon HG, Robertson WB. Fetal growth retardation and the arteries of the placental bed. Br J Obstet Gynaecol 1977; 84: 656-663.
5. De Wolf F, Brosens I, Renaer, M. Fetal growth retardation and the maternal arterial supply of the human placenta in the absence of sustained hypertension. Br J Obstet Gynecol 1980; 87:678-685.
6. Khong TY, De WF, Robertson WB, Brosens I. Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants. Br J Obstet Gynaecol 1986; 93: 1049-1059.
7. Gerretsen G, Huisjes HJ, Elema JD. Morphological changes of the spiral arteries in the placental bed in relation to pre-eclampsia and fetal growth retardation. Br J Obsret Gynaecol 1981; 88: 876-881.
8. Sheppard BL, Bonnar J. The ultrastructure of the arterial supply of the human placenta in pregnancy complicated by fetal growth retardation. Br J Obstet Gynaecol 83: 948-959.
9. Sheppard BL, Bonnar J. An ultrastructural study of utero-placental spiral arteries in hypertensive and normotensive pregnancy and fetal growth retardation. Br J Obster Gynaecol 1981; 88: 695-705.
10. Pijnenborg R, Dixon G, Robertson WB, Brosens I. Trophoblastic invasion of human decidua from 8 to 18 weeks of pregnancy. Placenta 1980; 1: 3-19.
11. Pijnenborg R, Robertson WB, Brosens I, Dixon G. Review article: trophoblast invasion and the establishment of haemochorial placentation in man and laboratory animals. Placenta 1981; 2: 71-91.
12. Van, Der Veen F, Fox H. The human placenta in idiopathic intrauterine growth retardation: a light and electron microscopic study. Placenta 1983; 4: 65-77.
13. Starkey PM. The decidua and factors controlling placentation. In: Starkey PM, editor. The Human Placenta. Oxford : Blackwell, 1993; 362-413.
14. Bridgman J. A morphological study of the development of the placenta of the rat II. A histological and cytological study of the development of the chorio-allantoic placenta of the white rat. J Morphol 1949; 83: 195-224.
15. Ramsey EM, Houston ML, Harris, JWS. Interactions of the trophoblast and maternal tissues in three closely related primate species. Am J Obstet Gynaecol 1976; 124: 647-652.
16. Ramsey, EM, editor. The Placenta, Human and Animal. New York : Praeger, 1982: 87-124.
17. Robinson JS, Owens J. The placenta and intrauterine growth retardation. In: Starkey PM, editor. The Human Placenta. Oxford : Blackwell Science, 1993: 558-578.
18. Glasser SR, Clark JH. A determinant role for progesterone in the development of uterine sensitivity to decidualization and ovo-implantation. In: Markert CL, Papaconstantinous, J, editors. The Developmental Biology of Reproduction. New York : Academic Press, 1975: 311-345.
19. Davies J, Glasser SR. Histological and fine structural observations on the placenta of the rat. Acta Anatom 1968; 69: 542-608.
20. Bell SC. Synthesis of ‘decidualization-associated protein’ in tissues of the rat uterus and placenta during pregnancy. J Reprod Fertil 1979; 56: 255-262.
21. Furr BJ, Patterson JS, Richardson DN, Slater SR, Wakeling AE. Tamoxifen. In: Goldbergs, ME Pharmacological and Biochemical Properties of Drug Substances. Washington DC : American Pharmaceutical Association, 1979: 355-399.
22. Tucker MJ, Adam HK, Patterson JS. Tamoxifen. In: Laurence DR, McLean AEM, Weatheralls, M, editors. Testing of New Drugs. New York : Academic Press, 1984: 125-161.
23. Tsujii T, Kambegawa A, Kobayashi M et al. Contraceptive effects of the antigestagenic agent RU486 in rats and rabbits. Asia Oceania J Obstet Gynecol 1989; 15: 169-173.
24. Philibert D, Moguilewsky M, Mary I et al. Pharmacological profile of RU486 in animals. In: Baulieu E, Segals, SJ, editors. The Antiprogestin Steroid RU486 and Human Fertility Control. New York : Plenum Press, 1985: 49-68.
25. Kelly RW, Healy DL, Cameron MJ, Cameron IT, Baird DT. RU486 stimulation of PGF2a production in isolated endometrial cells in short term culture. In: Baulieu EM, Segals, SJ, editors. The Antiprogestin Steroid RU486 and Human Fertility Control. New York : Plenum Press, 1985: 259-262.
26. Permezel M. The antiprogesterone steroid, RU486 (Mifepristone). Aust NZ J Obster Gynaecol 1990; 30: 77-80.
27. Deraedt R, Vannier B, Fournex R. Toxicological study on RU486.In: Baulieu E, Segals, SJ, editors. The Antiprogestin Steroid RU486 and Human Fertility Control. New York : Plenum Press, 1985: 123-126.
28. Henshaw RC, Templeton AA. Antiprogesterones. In: Studd, J, editors. Progress in Obstetrics and Gynaecology, Vol. 10. Edinburgh : Churchill Livingstone, 1993: 259-279.
29. Lim BH, Lees DAR, Bjornsson S et al. Normal development after exposure to mifepristone in early pregnancy. Lancet 1990 336: 257-258.
30. Pons JC, Imbert MC, Elefant E, Roux C, Herschkorn P, Papiernick E. Development after exposure to mifepristone in early pregnancy. Lancet 1991; 338: 763.
31. Hardy RP, New DAT. Effects of the anti-progestin RU38486 on rat embryos growing in culture. Food Chem Toxicol 1991; 29: 361-362.
32. Ogata ES, Finley SL. Selective ligation of uterine artery branches accelerates fetal growth in the rat. Ped Res 1988; 24: 384-390.
33. Beyer BK, Stark KL, Fantel A, Juchau MR. Biotransformation, oestrogenicity, and steroid structure as determinants of dys-morphogenic and generalized embryotoxic effects of steroidal and nonsteroidal estrogens. Toxicol Appl Pharmacol 1989; 98: 113-127.
34. Keeping HS, Lyttle CR. Modulation of rat uterine progesterone receptor levels and peroxidase activity by tamoxifen citrate, LY117018, and estradiol. Endocrinology 1982; 111: 2046-2054.
35. O'Grady JE, Armstrong EM, Moore I, Vass MA. Effect of tamoxifen (ICI-46,474) on mitosis in the uterus of the rat during the early stages of pregnancy. J Endocrinol 1974; 63(Suppl 2): 19.
36. Martel D, Monier MN, Psychoyos A, DeFeo VJ. Estrogen and progesterone receptors in the endometrium, myometrium and metrial gland of the rat during the decidualisation process. Endocrinology 1984; 114: 1627-1634.
37. McCormack SA, Glasser SR. A high-affinity estrogen-binding protein in rat placental trophoblast. Endocrinology 1976; 99: 701-712.
38. McCormack SA, Glasser SR. Ontogeny and regulation of rat placental estrogen receptor. Endocrinology 1978; 102: 273-280.
39. Milgrom E, Thi L, Baulieu EE. Control mechanisms of steroid hormone receptors in the reproductive tract. Acta Endocrinol 1973; 180 Suppl: 380-403.
40. Press M, Udove J, Greene GL. Progesterone receptor distribution in the human endometrium. Am J Pathol 1988; 131: 112-124.
41. Ogle TF, Nosek TM, Mills TM. Action of progesterone and RU486 on protein synthesis in rat placenta. In: Mahesh VB, Dhindsa DS, Anderson E, Kalras, SP, editors. Regulation of Ovarian and Testicular Function. New York : Plenum Press, 1987: 689-692.