Effects of indole-3-carbinol on immune responses, aberrant crypt foci, and colonic crypt cell proliferation in rats

Journal of Toxicology and Environmental Health - Part A

Volumn 62, Issue 7, 2001, Pages 561-573

  Exon, J H ^a   South, E H ^a   Magnuson, B A ^b   Hendrix, K ^a  

^a UNIVERSITY OF IDAHO   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 INDOLEMETHANOL; AZOXYMETHANE; DRUG VEHICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CANCER PREVENTION; CELL PROLIFERATION; CELLULAR IMMUNITY; COLON CARCINOGENESIS; CONTROLLED STUDY; CRYPT CELL; DELAYED HYPERSENSITIVITY; DOSE RESPONSE; HUMORAL IMMUNITY; IMMUNOTOXICITY; MALE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; RAT; VEGETABLE;

ANIMALS; ANTICARCINOGENIC AGENTS; AZOXYMETHANE; BIOLOGICAL MARKERS; BODY WEIGHT; CARCINOGENS; CELL DIVISION; COLONIC NEOPLASMS; HYPERSENSITIVITY, DELAYED; IMMUNITY; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; INDOLES; KILLER CELLS, NATURAL; MALE; PRECANCEROUS CONDITIONS; RATS; RATS, SPRAGUE-DAWLEY; SPLEEN;

ANIMALIA;

EID: 0035815495     PISSN: 15287394     EISSN: None     Source Type: Journal    
DOI: 10.1080/152873901300007842     Document Type: Article

References (38)

1. Bailey, G. S., Hendricks, J. D., Shelton, D. W., Nixon, J. E., and Pawlowski, N. W. 1987. Enhancement of carcinogenesis by the natural anticarcinogen indole-3-carbinol. JNCI 78:931-934.
2. Bird, R. P. 1995. Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett. 93:55-71.
3. Birt, D. F., Pelling, J. C., Pour, P. M., Tibbels, M. G., Schweikert, L., and Bresnick, E. 1987. Enhanced pancreatic and skin tumourigenesis in cabbage-fed hamsters and mice. Carcinogenesis 8:913-917.
4. Burns, L. A., Mead, B. J., and Munson, A. E. 1995. Toxic responses of the immune system. In Casarett and Doull's toxicology, ed. C. D. Klaassen, pp. 355-402. New York: McGraw Hill.
5. Bradlow, H. L., Michnovicz, J. J., Telang, N. T., and Osborne, M. P. 1991. Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice. Carcinogenesis 12:1571-1574.
6. Dashwood, R. H. 1998. Indole-3-carbinol: Anticarcinogen or tumor promoter in brassica vegetables? Chem. Biol. Interact. 110:1-5.
7. Dashwood, R. H., Fong, A. T., Williams, D. E., Hendricks, J. D., and Bailey, G. S. 1991. Promotion of aflatoxin B1 carcinogenesis by the natural tumor modulator indole-3-carbinol: Influence of dose, duration, and intermittent exposure on indole-3-carbinol promotional potency. Cancer Res. 51:2362-2365.
8. Exon, J. H., and South, E. H. 2000. Dietary indole-3-carbinol alters immune functions in rats. J. Toxicol. Environ. Health A 59:271-279.
9. Exon, J. H., Koller, L. D., Talcott, P. A., O'Reilly, C. A., and Henningsen, G. M. 1986. Immunotoxicity testing: An economical multiple-assay approach. Fundam. Appl. Toxicol. 7:387-397.
10. Exon, J. H., Brussiere, J. L., and Mather, G. G. 1990. Immunotoxicity testing in the rat: An improved multiple assay model. Int. J. Immunopharmacol. 12:699-701.
11. Ge, X., Yannai, S., Rennert, G., Gruener, N., and Fares, F. 1996. 3,3′-Diindolylmethane induces apoptosis in human cancer cells. Biochem. Biophys. Res. Commun. 228:153-158.
12. Graham, S. 1983. Results of case-control studies of diet and cancer in Buffalo, New York. Cancer Res. 43:2409-2413.
13. Grubbs, C. J., Steele, V. E., Casebolt, T., Juliana, M. M., Eto, I., Whitaker, L. M., Dragnev, K. H., Kelloff, G. J., and Lubet, R. L. 1995. Chemoprevention of chemically-induced mammary carcinogenesis by indole-3-carbinol. Anticancer Res. 15:709-716.
14. Guo, D., Schut, H. A. J., Davis, C. D., Snyderwine, E. G., Bailey, G. S., and Dashwood, R. H. 1995. Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat. Carcinogenesis 16:2931-2937.
15. He, Y. H., Friesen, M. D., Ruch, R. J., and Schut, H. A. J. 2000. Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: Inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytochrome P450 in female F344 rats. Food Chem. Toxicol. 38:15-23.
16. Ishizuka, S., Nagai, T., and Kasai, T. 1996. Administration of anti-asialo GM1 serum increases aberrant crypt foci induced by 1,2-dimethylhydrazine in the large bowel of rats. J. Nutr. Sci. Vitaminol. 42: 603-608.
17. Jongen, W. 1996. Glucosinolates in brassica: Occurrence and significance as cancer-modulating agents. Proc. Nutr. Soc. 55:433-446.
18. Kacew, S., and Festing, M. F. 1996. Role of rat strain in the differential sensitivity to pharmaceutical agents and naturally occurring substances. J. Toxicol. Environ. Health 47:1-30.
19. Kacew S., Ruben, Z., and McConnel, R. F. 1995. Strain as a determinant factor in the differential responsiveness of rats to chemicals. Toxicol. Pathol. 23:701-714.
20. Kim, D., Han, B., Ahn, B., Hasegawa, R., Shirai, T., Ito, N., and Tsuda, H. 1997. Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rat medium-term multiorgan carcinogenesis model. Carcinogenesis 18:377-381.
21. Kim, D. J., Lee, K. K., Bae, J. H., Jang, J. J., Tatematsu, M., and Furihata, C. 1994a. The inhibitory effects of allyl sulfide and indole-3-carbinol on N-methyl-N′-nitro-N-nitrosoguanidine-induced glandular stomach carcinogenesis in rats. J. Korean Cancer Assoc. 26:392-398.
22. Kim, D. J., Lee, K. K., Han, B. S., Ahn, B., Bae, J. H., and Jang, J. J. 1994b. Biphasic modifying effect of indole-3-carbinol on diethylnitrosamine-induced preneoplastic glutathione S-transferase placental form-positive liver cell foci in Sprague-Dawley rats. Jpn. J. Cancer Res. 85:578-583.
23. Kojima, T., Tanaka, T., and Mori, H. 1994. Chemoprevention of spontaneous endometrial cancer in female Donryu rats by dietary indole-3-carbinol. Cancer Res. 54:1446-1449.
24. Liu, H., Wormke, M., Safe, S. H., and Bjeldanes, L. F. 1994. Indol[3,2-b]carbazole: A dietary-derived factor that exhibits both antiestrogenic and estrogenic activity. JNCI 86:1758-1765.
25. Luster, M. I., Portier, C., Pait, D. G., White, K. L., Jr., Gennings, C., Munson, A. S., and Rosenthal, G. J. 1992. Risk assessment in immunotoxicology. I. Sensitivity and predictability of immune tests. Fundam. Appl. Toxicol. 18:200-210.
26. Luster, M. I., Portier, C., Pait, D. G., Rosenthal, G. J., Germolec, D. R., Corsini, E., Blaylock, B. L., Pollock, P., Kouchi, Y., Carig, W., White, S. L., Munson, A. E., and Comment, C. E. 1993. Risk assessment in immunotoxicology. II Relationships between immune and host resistance tests. Fundam. Appl. Toxicol. 21:71-82.
27. Manson, M. M., Ball, H. W. L., Barrett, M. C., Clark, H. L., Judah, D. J., Williamson, G., and Neal, G. E. 1997. Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism. Carcinogenesis 18:1729-1738.
28. Manson, M. M., Hudson, E. A., Ball, H. W. I., Barrett, M. C., Clark, H. L., Judah, D. J., Verschoyle, R. D., and Neal, G. E. 1998. Chemoprevention of aflatoxin B1-induced carcinogenesis by indole-3-carbinol in rat liver - Predicting the outcome using early biomarkers. Carcinogenesis 19: 1829-1836.
29. McLellan, E. A., and Bird, R. P. 1988. Aberrant crypts: Potential preneoplastic lesion in the murine colon. Cancer Res. 48:6187-6192.
30. Nasrullah, I., and Mazzeo, R. S. 1992. Age-related immunosenescence in Fischer 344 rats: Influence of exercise training. J. Appl. Physiol. 73:1932-1938.
31. Oganesian, A., Hendricks, J. D., and Williams, D. E. 1997. Long term dietary indole-3-carbinol inhibits diethylnitrosamine-initiated hepatocarcinogenesis in the infant mouse model. Cancer Lett. 118:87-94.
32. Pawelec, G., Adibzadeh, M., Phla, H., and Schaudt, K. 1995. Immunosenescence: Aging of the immune system. Immunol. Today 16:420-422.
33. Pence, B. C., Buddingh, F., and Yang, S. P. 1986. Multiple dietary factors in the enhancement of dimethylhydrazine carcinogenesis: Main effect of indole-3-carbinol. JNCI 77:269-276.
34. Tanaka, T., Kojima, T., Morishita, Y., and Mori, H. 1992. Inhibitory effects of the natural products indole-3-carbinol and sinigrin during initiation and promotion phases of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. Jpn. J. Cancer Res. 83:835-842.
35. Wargovich, M. J., Chen, C.-D., Jimenez, A., Steele, V. W., Velasco, M., Stephens, L. C., Price, R., Gray, K., and Kelloff, G. J. 1996. Aberrant crypts as a biomarker for colon cancer: Evaluation of potential chemopreventive agents in the rat. Cancer Epidemiol. Biomarkers Prev. 5:355-360.
36. Wattenberg, L. W., and Loub, W. D. 1978. Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles. Cancer Res. 38:1410-1413.
37. Xu, M., Bailey, A. C., Hernaez, J. F., Taoka, C. R., Schut, H. A. J., and Dashwood, R. H. 1996. Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]-quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat. Carcinogenesis 17:1429-1434.
38. Yamada, K., Yoshitake, K., Sato, M., and Ahnen, D. J. 1992. Proliferating cell nuclear antigen expression in normal, preneoplastic, and neoplastic colonic epithelium. Gastroenterology 103:160-197.