Conservation of the LD1 region in Leishmania includes DNA implicated in LD1 amplification

Molecular and Biochemical Parasitology

Volumn 113, Issue 2, 2001, Pages 315-321

  Sunkin, Susan M ^a   McDonagh, Paul ^b   Cunningham, Mark L ^c   Beverley, Stephen M ^c   Stuart, Kenneth ^a,d   Myler, Peter J ^a,d  

^a SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^b ROSETTA INPHARMATICS   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Amplified DNA; Genomic organization; Leishmania DNA 1 (LD1); Leishmania major Friedlin; Sequence comparison

Indexed keywords

ADENOSYLMETHIONINE DECARBOXYLASE; DNA DIRECTED DNA POLYMERASE ALPHA; HEAT SHOCK PROTEIN; METHIONINE ADENOSYLTRANSFERASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTOZOAL DNA; PROTOZOAL RNA;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; DNA SEQUENCE; GENE AMPLIFICATION; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC CODE; KINETOPLAST; LEISHMANIA BRAZILIENSIS; LEISHMANIA DONOVANI; LEISHMANIA INFANTUM; LEISHMANIA MAJOR; LEISHMANIA MEXICANA; LEISHMANIA TARENTOLAE; MINICHROMOSOME; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYADENYLATION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STRAIN DIFFERENCE;

ANIMALS; CONSERVED SEQUENCE; DNA, PROTOZOAN; GENE AMPLIFICATION; GENES, PROTOZOAN; LEISHMANIA; MOLECULAR SEQUENCE DATA; PROTOZOAN PROTEINS; SEQUENCE ANALYSIS, DNA;

LEISHMANIA BRAZILIENSIS; LEISHMANIA DONOVANI; LEISHMANIA INFANTUM; LEISHMANIA MAJOR; LEISHMANIA MEXICANA; LEISHMANIA TARENTOLAE; PROTOZOA;

EID: 0035815318     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(01)00215-8     Document Type: Article

References (49)

1. DNA amplification: New insights into its mechanism
2. The arrangement of length heterogeneity in repeating units and chromosomal rRNA from Xenopus laevis
3. Recent progress in understanding mechanisms of mammalian DNA amplification
4. The multicopy appearance of a large inverted duplication and the sequence at the inversion point suggest a new model for gene amplification
5. Sister chromatid fusion initiates amplification of the dihydrofolate reductase gene in Chinese hamster cells
6. Gene amplification in Leishmania
7. Circular and linear multicopy DNAs in Leishmania
8. Leishmania gene amplification: A mechanism of drug resistance
9. LD1 amplification in Leishmania
10. A novel antifolate resistance gene on the amplified H circle of Leishmania
11. Mechanisms of drug resistance in Leishmania
12. Extrachromosomal elements in the lower eukaryote Leishmania
13. Amplification of a new region of DNA in an unselected laboratory stock of L. tarentolae: The T region
14. A DNA sequence (LD1) which occurs in several genomic organizations in Leishmania
15. A multicopy, extrachromosomal DNA in Leishmania infantum contains two inverted repeats of the 27.5 kb LD1 sequence and encodes numerous transcripts
16. Chromosome rearrangement in Leishmania mexicana M379
17. Inverted repeat structure and homologous sequences in the LD1 amplicons of Leishmania spp
18. Recurrent de novo appearance of small linear DNAs in Leishmania major and relationship to extra-chromosomal DNAs in other species
19. Recurrent polymorphisms in small chromosomes of Leishmania tarentolae after nutrient stress or subcloning
20. Dynamics and size polymorphisms of minichromosomes in Leishmania major LV-561 cloned lines
21. Analysis of the genomic organisation of a small chromosome of Leishmania braziliensis M2903 reveals two genes encoding GTP-binding proteins, one of which belongs to a new G-protein family and is an antigen
22. The LD1 amplified element from Leishmania infantum encodes a homolog of ribosomal protein L37
23. An amplified DNA element in Leishmania encodes potential integral membrane and nucleotide binding proteins
24. A frequently amplified region in Leishmania contains a gene that is conserved in prokaryotes and eukaryotes
25. Increased expression of LD1 genes transcribed by RNA polymerase I in Leishmania donovani as a result of duplication into the rRNA gene locus
26. Evolution of the genus Leishmania revealed by comparison of DNA and RNA polymerase gene sequences
27. Identification and characterisation of a Leishmania donovani antigen belonging to the 70-kDa heat-shock protein family
28. A physical map of the Leishmania major Friedlin genome
29. The Leishmania donovani LD1 locus gene ORFG encodes a biopterin transporter (BT1)
30. Recognition of protein coding regions in DNA sequences
31. Microbial gene identification using interpolated Markov models
32. mRNA processing in the Trypanosomatidae
33. Coupling of poly(A) site selection and trans-splicing in Leishmania
34. A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes
35. Leishmania major Friedlin chromosome 1 has an unusual distribution of protein-coding genes
36. The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum
37. Genome sequence of the nematode C. elegans: A platform for investigating biology
38. Recent developments from the Leishmania genome project
39. Poly(A) binding protein I of Leishmania: Functional analysis and localization in trypanosomatid parasites
40. Regulation of the mRNA levels of nimA, a gene required for the G2-M transition in Aspergillus nidulans
41. A member of the clpb family of stress proteins is expressed during heat shock in Leishmania spp
42. Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae
43. DNA recombination associated with short direct repeats in Leishmania mexicana M379
44. Location in the source chromosome of the 180-kb minichromosome of Leishmania major and characterization of the novel junction
45. Characterisation of the novel junctions of two minichromosomes of Leishmania major
46. The mechanism of carcinogen-induced DNA amplification: In vivo and in vitro studies
47. 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans