Basal expression of the rat, but not of the human, multidrug resistance protein 2 (MRP2) gene is mediated by CBF/NF-Y and Sp1 promoter-binding sites

Toxicology

Volumn 167, Issue 1, 2001, Pages 25-35

  Kauffmann, Hans Martin ^a   Vorderstemann, Birgit ^a   Schrenk, Dieter ^a  

^a Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

Author keywords

Basal expression; Multidrug resistance protein 2 (MRP2); Promoter; Regulation

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 2; N (2 FLUORENYL)ACETAMIDE; NUCLEAR FACTOR; NUCLEAR FACTOR Y; OLIGONUCLEOTIDE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CBF; TRANSCRIPTION FACTOR EFIA; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; Y BOX BINDING PROTEIN 1;

ANIMAL CELL; ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE ACTIVITY; GENE CONTROL; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; REPORTER GENE; SITE DIRECTED MUTAGENESIS;

2-ACETYLAMINOFLUORENE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BINDING SITES; CARCINOGENS; CARCINOMA, HEPATOCELLULAR; CARRIER PROTEINS; CCAAT-BINDING FACTOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; LIVER NEOPLASMS, EXPERIMENTAL; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTAGENESIS, SITE-DIRECTED; P-GLYCOPROTEINS; PROMOTER REGIONS (GENETICS); RATS; SP1 TRANSCRIPTION FACTOR; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0035813005     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(01)00455-3     Document Type: Article

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