The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9

Biochemical and Biophysical Research Communications

Volumn 287, Issue 4, 2001, Pages 932-940

  Xiang, Shuang Lin ^a   Kumano, Tomoyasu ^a   Iwasaki, Shu ichi ^a   Sun, Xiangao ^a   Yoshioka, Kastuji ^a   Yamamoto, Ken chi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cell cycle checkpoint; Chaperone; Hus1; J domain; Rad1; Rad9; Tetratricopeptide repeat

Indexed keywords

CELL PROTEIN; HUS1 PROTEIN; PROTEIN RAD1; PROTEIN RAD9; TETRATRICOPEPTIDE REPEAT PROTEIN 2; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CELLULAR DISTRIBUTION; COMPLEX FORMATION; DISSOCIATION; GENE DELETION; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE REPEAT; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; TWO HYBRID SYSTEM; ULTRAVIOLET RADIATION;

EID: 0035812765     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5685     Document Type: Article

References (33)

1. The G2-phase DNA-damage checkpoint
2. The DNA damage response: Putting checkpoints in perspective
3. DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe
4. Fission yeast genes involved in coupling mitosis to completion of DNA replication
5. Checkpoint controls in Schizosaccharomyces pombe: Rad1
6. A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene
7. Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage
8. Human and mouse homologs of Schizosaccharomyces pombe rad1+ and Saccharomyces cerevisiae RAD17: Linkage to checkpoint control and mammalian meiosis
9. A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease
10. Human DNA damage checkpoint protein hRAD9 is a 3′ to 5′ exonuclease
11. A sliding clamp model for the Rad1 family of cell cycle checkpoint proteins
12. Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes
13. Characterization of Schizosaccharomyces pombe Hus1: A PCNA-related protein that associates with Rad1 and Rad9
14. BH3-only proteins-essential initiators of apoptotic cell death
15. Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-xl and promotes apoptosis
16. Schizosaccharomyces pombe Rad9 contains a BH3-like region and interacts with the anti-apoptotic protein Bcl-2
17. Identification and characterization od two novel tetratricopeptide repeat-containing genes
18. The TPR snap helix: A novel protein repeat motif from mitosis to transcription
19. Tetratrico peptide repeat interactions: To TPR or not to TPR?
20. Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats
21. The J-domain family and the recruitment of chaperone power
22. Genetic suppression of polyglutamine toxicity in Drosophila
23. The 58,000-Dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins
24. Inhibition of double-stranded RNA- and tumor necrosis factor Alpha-mediated apoptosis by tetratricopeptide repeat protein and cochaperone p58IPK
25. JSAP1, a novel JNK3-binding protein that functions as a scaffold factor in the JNK signaling pathway
26. Human homologs of Schizosaccharomyces pombe Rad1, Hus1 and Rad9 forma DNA damage-responsive protein complex
27. The human G2 checkpoint control protein hRad9 is a nuclear phosphoprotein that forms complexes with hRad1 and hHus1
28. Physical interactions among human checkpoint control proteins Hus1p, Rad1p and Rad9p and implications for the regulation of cell cycle progression
29. Retention of the hRad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage
30. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome
31. Negative regulation of the Apsf-1 apoptosome by Hsp70
32. The chaperone function of hsp70 is required for protection against stress-induced apoptosis
33. Hsp72-mediated suppression of c-jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death