Okadaic acid-induced upregulation of nitrotyrosine and heme oxygenase-1 in rat cortical neuron cultures

Neuroscience Letters

Volumn 297, Issue 1, 2001, Pages 33-36

  Kim, DongHou ^a   Koh, Woo Kyoung ^a   Kim, Jong Uk ^a   Lee, Jong Hwan ^b   Hong, Hea Nam ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

Alzheimer's disease; Neuronal cells; Okadaic acid; Oxidative damage

Indexed keywords

3 NITROTYROSINE; HEME OXYGENASE; OKADAIC ACID; PROTEIN C JUN; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; ASTROCYTE; CELL CULTURE; CONTROLLED STUDY; EMBRYO; FLUORESCENCE; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; NERVE CELL; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; EMBRYO; ENZYME INHIBITORS; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; NEURONS; OKADAIC ACID; PHOSPHORYLATION; RATS; TYROSINE; UP-REGULATION;

EID: 0035808664     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01661-X     Document Type: Article

References (20)

1. Paired helical filament-like phosphorylation of tau, deposition of β/A4-amyloid and memory impairment in rat induced by chronic inhibition of phosphatase 1 and 2A
2. Oxidative stress induces dephosphorylation of tau in rat brain primary neuronal cultures
3. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
4. Evidence for neuronal oxidative damage in Alzheimer's disease
5. Transcriptional induction of heme oxygenase-1 gene expression by okadaic acid in primary rat hepatocyte cultures
6. Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species
7. Sequence of neurodegeneration and accumulation of phosphorylated tau in cultured neurons after okadaic acid treatment
8. The formation of PHF-1 and SMI-31 positive dystrophic neurites in rat hippocampus following acute injection of okadaic acid
9. Oxidative alteration in Alzheimer's disease
10. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
11. E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures
12. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease
13. Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice
14. Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain
15. Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease
16. Quantitative solubilization and analysis of insoluble paired helical filaments from Alzheimer disease
17. Widespread peroxynitrite-mediated damage in Alzheimer's disease
18. Bax protein expression is increased in Alzheimer's brain: correlations with DNA damage, Bcl-2 expression and brain pathology
19. In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of induced by 4-hydroxy-2-nonenal modification
20. The phosphatase inhibitor okadaic acid induces a phosphorylated paired helical filament tau epitope in human LA-N-5 neuroblastoma cells