The formation of PHF-1 and SMI-31 positive dystrophic neurites in rat hippocampus following acute injection of okadaic acid

Neuroscience Letters

Volumn 282, Issue 1-2, 2000, Pages 49-52

  Lee, Jong Hwan ^a   Hong, Hea Nam ^a   Im, Jin Ok ^a   Byun, Hong Seob ^a   Kim, Donghou ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

22C11; Amyloid precursor protein; Microtubule associated protein 2; Okadaic acid; Paired helical filament 1; Sternberger monoclonals incorporated 31; Tau phosphorylation

Indexed keywords

AMYLOID PRECURSOR PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; OKADAIC ACID; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DYSTROPHY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NEURITE; NONHUMAN; PAIRED HELICAL FILAMENT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIBODIES, MONOCLONAL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INJECTIONS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; NEURITES; NEUROFIBRILLARY TANGLES; OKADAIC ACID; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0034678022     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)00863-6     Document Type: Article

References (19)

1. Arendt T., Holzer M., Brückner M.K., Janke C., Gärtner U. The use of okadaic acid in vivo and the induction of molecular changes typical for Alzheimer's disease. Neuroscience. 85:1998;1337-1340.
2. Arendt T., Holzer M., Fruth R., Brückner M.K., Gärtner U. Phosphorylation of tau, Aβ-formation, and apoptosis after in vivo inhibition of PP-1 and PP2A. Neurobiol. Aging. 19:1998;3-13.
3. Arendt T., Holzer M., Fruth R., Brückner M.K., Gärtner U. Paired helical filament-like phosphorylation of tau, deposition of β/A4-amyloid and memory impairment in rat induced by chronic inhibition of phosphatase 1 and 2A. Neuroscience. 69:1995;691-698.
4. Arriagada P.V., Growdon J.H., Hedley-Whyte E.T., Hyman B.T. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology. 42:1992;631-639.
5. Hedreen J.C., Koliatsos V.E. Phosphorylated neurofilament in neuronal perikarya and dendrites in human brain following axonal damage. J. Neuropathol. Exp. Neurol. 53:1994;663-671.
6. Koliatsos V.E., Applegate M.D., Kitt C.A., Walker L.C., DeLong M.R., Price D.L. Aberrant phosphorylation of neurofilaments accompanies transmitter-related changes in rat septal neurons following transection of the fimbria-fornix. Brain Res. 482:1989;205-218.
7. Lee V.M-Y., Balin B.J., Otvos L. Jr., Trojanowski J.Q. A major subunit of paired helical filaments and derivatized forms of normal tau. Science. 251:1991;675-678.
8. Masliah E., Mallory M., Hansen L., Alford M., DeTeresa R., Terry R. An antibody against phosphorylated neurofilaments identifies a subset of damaged association axons in Alzheimer's disease. Am. J. Pathol. 142:1993;871-882.
9. McKee A.C., Kosik K.S., Kowall N.W. Neuritic pathology and dementia in Alzheimer's disease. Ann. Neurol. 30:1991;156-165.
10. Morishima-Kawashima M., Hasegawa M., Takio K., Suzuki M., Yoshida H., Titani K., Ihara Y. Proline-directed and non-proline-directed phosphorylation of PHF-tau. J. Biol. Chem. 270:1995;823-829.
11. Mudher A.K., Perry V.H. Using okadaic acid as a tool for the in vivo induction of hyperphosphorylated tau. Neuroscience. 85:1998;1329-1332.
12. Otsuka N., Tomonaga M., Ikeda K. Rapid appearance of β-amyloid precursor protein immunoreactivity in damaged axons and reactive glial cells in rat brain following needle stab injury. Brain Res. 568:1991;335-338.
13. Su J.H., Cummings B.J., Cotman C.W. Plaque biogenesis in brain aging and Alzheimer's disease. II. Progressive transformation and developmental sequence of dystrophic neurites. Acta Neuropathol. 96:1998;463-471.
14. Su J.H., Cummings B.J., Cotman C.W. Plaque biogenesis in brain aging and Alzheimer's disease. I. Progressive changes in phosphorylation states of paired helical filaments and neurofilaments. Brain Res. 739:1996;79-87.
15. Van Dam A.M., Bol J.G.J.M., Binnekade R., Muiswinkel F.L. Acute or chronic administration of okadaic acid to rats induces brain damage rather than Alzheimer-like neuropathology. Neuroscience. 85:1998;1333-1335.
16. Vickers J.C. A cellular mechanism for the neuronal changes underlying Alzheimer's disease. Neuroscience. 78:1997;629-639.
17. Vickers J.C., Chin D., Edwards A-M., Sampson V., Harper C., Morrison J. Dystrophic neurite formation associated with age-related β-amyloid deposition in the neocortex: clues to the genesis of neurofibrillary pathology. Exp. Neurol. 141:1996;1-11.
18. Wang D., Munoz D.G. Qualitative and quantitative differences in senile plaque dystrophic neurites of Alzheimer's disease and normal aged brain. J. Neuropathol. Exp. Neurol. 54:1995;548-556.
19. Yankner B.A., Mesulam M.M. β-Amyloid and the pathogenesis of Alzheimer's disease. N. Engl. J. Med. 325:1991;1849-1857.