Isoform-specific effects of apolipoprotein E on atherogenesis gene transduction studies in mice

Circulation

Volumn 104, Issue 23, 2001, Pages 2820-2825

  Yoshida, Hiroaki ^a   Hasty, Alyssa H ^a   Major, Amy S ^a   Ishiguro, Hiroyuki ^a   Su, Yan Ru ^a   Gleaves, Linda A ^a   Babaev, Vladimir R ^a   Linton, MacRae F ^a   Fazio, Sergio ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apolipoproteins; Lipoproteins; Proteoglycans; Receptors

Indexed keywords

APOLIPOPROTEIN E; LOW DENSITY LIPOPROTEIN RECEPTOR; PROTEOHEPARAN SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CELL MEMBRANE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE THERAPY; GENETIC TRANSDUCTION; HEART PROTECTION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; RETROVIRUS;

EID: 0035808002     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc4801.100034     Document Type: Article

References (23)

1. Atherosclerosis: An inflammatory disease
2. Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall
3. Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice
4. Retroviral gene therapy in apoE-deficient mice: apoE expression in the artery wall reduces early foam cell lesion formation
5. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree
6. Atherosclerosis in mice lacking apoE: Evaluation of lesional development and progression
7. Prevention of atherosclerosis in apoE deficient mice by bone marrow transplantation
8. Apolipoprotein E secretion by macrophages: Its potential physiological functions
9. ApoE in atherosclerosis: A protein with multiple hats
10. Recent insights into the pathogenesis of type III hyperlipoproteinemia
11. Variable heparan sulfate proteoglycan binding of apolipoprotein E variants may modulate the expression of type III hyperlipoproteinemia
12. Bone marrow transplantation normalizes lipid and lipoprotein levels in apolipoprotein E deficient mice
13. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI
14. Liver-directed gene transfer and prolonged expression of three major human apoE isoforms in apoE-deficient mice
15. Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2
16. Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E
17. Susceptibility to diet-induced atherosclerosis in transgenic mice expressing a dysfunctional human apolipoprotein E (Arg112, Cys142)
18. Quantitation of atherosclerosis in murine models: Correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice
19. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E
20. Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice
21. Cell surface proteoglycans modulate net synthesis and secretion of macrophage apolipoprotein E
22. The heparin-binding proteins apolipoprotein E and lipoprotein lipase enhance cellular proteoglycan production
23. Apolipoprotein E-dependent cholesterol efflux from macrophages: Kinetic study and divergent mechanisms for endogenous versus exogenous apolipoprotein E