Membrane insertion of the heptameric staphylococcal α-toxin pore. A Domino-like structural transition that is allosterically modulated by the target cell membrane

Journal of Biological Chemistry

Volumn 276, Issue 18, 2001, Pages 14835-14841

  Valeva, Angela ^a   Schnabel, Ronny ^a   Walev, Iwan ^a   Boukhallouk, Fatima ^a   Bhakdi, Sucharit ^a   Palmer, Michael ^b  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; LIPIDS; ORGANIC POLYMERS;

ALLOSTERIC TRANSITIONS;

CELL MEMBRANES;

MEMBRANE LIPID; STAPHYLOCOCCUS ALPHA TOXIN; BACTERIAL TOXIN; HEMOLYSIN; PRIMER DNA; STAPHYLOCOCCAL ALPHA-TOXIN;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CHANNEL GATING; CONFORMATIONAL TRANSITION; ERYTHROCYTE; FIBROBLAST; HUMAN; HUMAN CELL; LIPID BILAYER; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; RABBIT; TOXIN ANALYSIS; ANIMAL; CELL MEMBRANE; CHEMISTRY; GENETICS; METABOLISM; MUTAGENESIS; NUCLEOTIDE SEQUENCE;

ANIMALIA; BACTERIA (MICROORGANISMS); EUKARYOTA; INSERTION SEQUENCES; ORYCTOLAGUS CUNICULUS; STAPHYLOCOCCUS;

ALLOSTERIC REGULATION; ANIMALS; BACTERIAL TOXINS; BASE SEQUENCE; CELL MEMBRANE; DNA PRIMERS; FIBROBLASTS; HEMOLYSIN PROTEINS; HUMANS; MUTAGENESIS; RABBITS;

EID: 0035805604     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M100301200     Document Type: Article

References (25)

1. Fuessle, R., Bhakdi, S., Sziegoleit, A., Tranum Jensen, J., Kranz, T., and Wellensiek, H. J. (1981) J. Cell Biol. 91, 83-94
2. Gouaux, J. E., Braha, O., Hobaugh, M., Song, L., Cheley, S., Shustak, C., and Bayley, H. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 12828-12831
3. Song, L., Hobaugh, M. R., Shustak, C., Cheley, S., Bayley, H., and Gouaux, J. E. (1996) Science 274, 1859-1866
4. Valeva, A., Weisser, A., Walker, B., Kehoe, M., Bayley, H., Bhakdi, S., and Palmer, M. (1996) EMBO J. 15, 1857-1864
5. Valeva, A., Walev, I., Pinkernell, M., Walker, B., Bayley, H., Palmer, M., and Bhakdi, S. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 11607-11611
6. Olson, R., Nariya, H., Yokota, K., Kamio, Y., and Gouaux, E. (1999) Nat. Struct. Biol. 6, 134-140
7. Pedelacq, J. D., Maveyraud, L., Prevost, G., Baba, M. L., Gonzalez, A., Courcelle, E., Shepard, W., Monteil, H., Samama, J. P., and Mourey, L. (1999) Struct. Fold. Des 7, 277-287
8. Walker, B., Krishnasastry, M., Zorn, L., and Bayley, H. (1992) J. Biol. Chem. 267, 21782-21786
9. Valeva, A., Palmer, M., Hilgert, K., Kehoe, M., and Bhakdi, S. (1995) Biochim. Biophys. Acta 1236, 213-218
10. Panchal, R. G., and Bayley, H. (1995) J. Biol. Chem. 270, 23072-23076
11. Valeva, A., Palmer, M., and Bhakdi, S. (1997) Biochemistry 36, 13298-13304
12. Vandana, S., Raje, M., and Krishnasastry, M. V. (1997) J. Biol. Chem. 272, 24858-24863
13. Bayley, H. (1999) Curr. Opin. Biotechnol. 10, 94-103
14. Russo, M. J., Bayley, H., and Toner, M. (1997) Nat. Biotechnol, 15, 278-282
15. Eroglu, A., Russo, M. J., Bieganski, R., Fowler, A., Cheley, S., Bayley, H., and Toner, M. (2000) Nat. Biotechnol. 18, 163-167
16. Collawn, J. F., Stangel, M., Kuhn, L. A., Esekogwu, V., Jing, S. Q., Trowbridge, I. S., and Tainer, J. A. (1990) Cell 63, 1061-1072
17. Collawn, J. F., Lai, A., Domingo, D., Fitch, M., Hatton, S., and Trowbridge, I. S. (1993) J. Biol. Chem. 268, 21686-21692
18. Cormack, B. (1987) in Current Protocols in Molecular Biology (Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. M., Seidman, J. G., Smith, J. A., and Struhl, K., eds) pp. 8.5.1-8.5.9, Wiley & Sons, New York
19. Fairweather, N., Kennedy, S., Foster, T. J., Kehoe, M., and Dougan, G. (1983) Infect. Immun. 41, 1112-1117
20. Palmer, M., Jursch, R., Weller, U., Valeva, A., Hilgert, K., Kehoe, M., and Bhakdi, S. (1993) J. Biol. Chem. 268, 11959-11962
21. Valeva, A., Pongs, J., Bhakdi, S., and Palmer, M. (1997) Biochim. Biophys. Acta 1325, 281-286
22. Mayer, L. D., Hope, M. J., and Cullis, P. R. (1986) Biochim. Biophys. Acta 858, 161-168
23. Bhakdi, S., Muhly, M., and Fuessle, R. (1984) Infect. Immun. 46, 318-323
24. Walev, I., and Bhakdi, S. (1996)Antimicrob. Agents Chemother. 40, 1116-1120
25. Walker, B., and Bayley, H. (1995) J. Biol. Chem. 270, 23065-23071