A novel CCCH protein which modulates differentiation of Trypanosoma brucei to its procyclic form

EMBO Journal

Volumn 20, Issue 23, 2001, Pages 6700-6711

  Hendriks, Edward F ^a   Robinson, Derrick R ^a,b   Hinkins, Matthew ^a   Matthews, Keith R ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

CCCH protein; Differentiation; Morphology; Trypanosoma brucei

Indexed keywords

PROTEIN CCCH; RNA; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

AMINO ACID COMPOSITION; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRUCTURE; CYTOSKELETON; GENE EXPRESSION; LIFE CYCLE; MICROTUBULE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN MOTIF; TRYPANOSOMA BRUCEI;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CYTOSKELETON; DNA PRIMERS; DNA-BINDING PROTEINS; LIGASES; MICROSCOPY, FLUORESCENCE; MICROTUBULES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PHENOTYPE; PLASMIDS; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS; RNA; SEQUENCE HOMOLOGY, AMINO ACID; TIME FACTORS; TRYPANOSOMA BRUCEI BRUCEI; UBIQUITIN-PROTEIN LIGASES; ZINC FINGERS;

EID: 0035803397     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.23.6700     Document Type: Article

References (34)

1. A novel epitope tag system to study protein targeting and organelle biogenesis in Trypanosoma brucei
2. Vectors for inducible expression of toxic gene products in bloodstream and procyclic Trypanosoma brucei
3. Changes in oxidative metabolism and ultrastructure accompanying differentiation of the mitochondrion in Trypanosoma brucei
4. Cultivation and in vitro cloning of procyclic forms of Trypanosoma brucei in a semi-defined medium
5. Feedback inhibition of macrophage tumor necrosis factor-α production by tristetraprolin
6. Cell differentiation in Naegleria gruberi
7. Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers
8. Rat monoclonal antitubulin antibodies derived by using a new nonsecreting rat cell line
9. Double-stranded RNA interference in Trypanosoma brucei using head-to-head promoters
10. Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor α mRNA
11. Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to AU-rich elements and destabilization of mRNA
12. Functional analysis of the trypanosomal AAA protein TbVCP with trans-dominant ATP hydrolysis mutants
13. Control of mRNA decay by heat shock-ubiquitin-proteasome pathway
14. Evidence for an interplay between cell cycle progression and the initiation of differentiation between life cycle forms of African trypanosome
15. Identification of stage specific and differentiation enriched transcripts during transformation of the African trypanosome from its bloodstream to procyclic form
16. Mitochondrial genome repositioning during the differentiation of the African trypanosome between life cycle forms is microtubule mediated
17. Double-stranded RNA induces mRNA degradation in Trypanosoma brucei
18. Molecular mechanisms regulating myogenic determination and differentiation
19. Identification of novel human WW domain-containing proteins by cloning of ligand targets
20. Evidence for novel cell cycle checkpoints in trypanosomes: Kinetoplast segregation and cytokinesis in the absence of mitosis
21. Asymmetric segregation of PIE-1 in C. Elegans is mediated by two complementary mechanisms that act through separate PIE-1 protein domains
22. Procyclin: An unusual immunodominant glycoprotein surface antigen from the procyclic stage of African trypanosomes
23. Microtubule polarity and dynamics in the control of organelle positioning segregation and cytokinesis in the trypanosome cell cycle
24. Visualization of detyrosination along single microtubules reveals novel mechanisms of assembly during cytoskeletal duplication in trypanosomes
25. Distinct localization and cell cycle dependence of COOH terminally tyrosinolated α-tubulin in the microtubules of Trypanosoma brucei brucei
26. Genetic interference in Trypanosoma brucei by heritable and inducible double-stranded RNA
27. pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C.elegans
28. A novel selection regime for differentiation defects demonstrates an essential role for the stumpy form in the life cycle of the African trypanosome
29. Cytochrome oxidase subunit VI of Trypanosoma brucei is imported without a cleaved presequence and is developmentally regulated at both RNA and protein levels
30. Molecular mechanisms of neurite extension
31. Control of gene expression in trypanosomes
32. On growth and form: Control of cell morphogenesis in fission yeast
33. Developmental cycles and biology of pathogenic trypanosomes
34. A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei