Cooperative Pho2-Pho4 interactions at the PHO5 promoter are critical for binding of Pho4 to UASp1 and for efficient transactivation by Pho4 at UASp2

Molecular and Cellular Biology

Volumn 18, Issue 5, 1998, Pages 2629-2639

  Barbaric, Slobodan ^a,b   Münsterkötter, Martin ^b   Goding, Colin ^c   Hörz, Wolfram ^b  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b UNIVERSITY OF MUNICH   (Germany)

^c MARIE CURIE RESEARCH INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; HELIX LOOP HELIX PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; SACCHAROMYCES CEREVISIAE; TRANSACTIVATION; TRANSCRIPTION REGULATION;

SACCHAROMYCES CEREVISIAE;

EID: 2642607009     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.18.5.2629     Document Type: Article

References (32)

1. Almer A., and W. Hörz. 1986. Nuclease hypersensitive regions with adjacent positioned nucleosomes mark the gene boundaries of the PHO5/PHO3 locus in yeast. EMBO J. 5:2681-2687.
2. Almer A., H. Rudolph, A. Hinnen, and W. Hörz. 1986. Removal of positioned nucleosomes from the yeast PHO5 promoter upon PHO5 induction releases additional upstream activating DNA elements. EMBO J. 5:2689-2696.
3. Arndt, K. T., C. Styles, and G. R. Fink. 1987. Multiple global regulators control HIS4 transcription in yeast. Science 237:874-880.
4. Barbaric, S., K. D. Fascher, and W. Hörz. 1992. Activation of the weakly regulated PHO8 promoter in S. cerevisiae: chromatin transition and binding sites for the positive regulator protein PHO4. Nucleic Acids Res. 20:1031-1038.
5. Barbaric, S., M. Münsterkötter, J. Svaren, and W. Hörz. 1996. The homeodomain protein Pho2 and the basic-helix-loop-helix protein Pho4 bind DNA cooperatively at the yeast PHO5 promoter. Nucleic Acids Res. 24:4479-4486.
6. Braus G., H. U. Mösch, K. Vogel, A. Hinnen, and R. Hütter. 1989. Inter-pathway regulation of the TRP4 gene of yeast. EMBO J. 8:939-945.
7. Brazas, R. M., L. T. Bhoite, M. D. Murphy, Y. X. Yu, Y. Y. Chen, D. W. Neklason, and D. J. Stillman. 1995. Determining the requirements for cooperative DNA binding by Swi5p and Pho2p (Grf10p/Bas2p) at the HO promoter. J. Biol. Chem. 270:29151-29161.
8. Daignan-Fornier, B., and G. R. Fink. 1992. Coregulation of purine and histidine biosynthesis by the transcriptional activators BAS1 and BAS2. Proc. Natl. Acad. Sci. USA 89:6746-6750.
9. Fascher, K. D., J. Schmitz, and W. Hörz. 1990. Role of trans-activating proteins in the generation of active chromatin at the PHO5 promoter in S. cerevisiae. EMBO J. 9:2523-2528.
10. Fascher, K. D., J. Schmitz, and W. Hörz. 1993. Structural and functional requirements for the chromatin transition at the PHO5 promoter in Saccharomyces cerevisiae upon PHO5 activation. J. Mol. Biol. 231:658-667.
11. Guarente, L., and M. Ptashne. 1981. Fusion of Escherichia coli lacZ to the cytochrome c gene of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 78:2199-2203.
12. Hirst, K., F. Fisher, P. C. McAndrew, and C. R. Goding. 1994. The transcription factor, the cdk, its cyclin and their regulator: directing the transcriptional response to a nutritional signal. EMBO J. 13:5410-5420.
13. Jayaraman, P. S., K. Hirst, and C. R. Goding. 1994. The activation domain of a basic helix-loop-helix protein is masked by repressor interaction with domains distinct from that required for transcription regulation. EMBO J. 13:2192-2199.
14. Justice, M. C., B. P. Hogan, and A. K. Vershon. 1997. Homeodomain-DNA interactions of the Pho2 protein are promoter-dependent. Nucleic Acids Res 25:4730-4739.
15. Kaffman, A., I. Herskowitz, R. Tjian, and E. K. O'Shea. 1994. Phosphorylation of the transcription factor Pho4 by a cyclin-CDK complex, Pho80-Pho85. Science 263:1153-1156.
16. Laughon, A. 1991. DNA binding specificity of homeodomains. Biochemistry 30:11357-11367.
17. Lenburg, M. E., and E. K. Oshea. 1996. Signaling phosphate starvation. Trends Biochem. Sci. 21:383-387.
18. McBride, H. J., R. M. Brazas, Y. Yu, K. Nasmyth, and D. J. Stillman. 1997. Long-range interactions at the HO promoter. Mol. Cell. Biol. 17:2669-2678.
19. O'Neill, E. M., A. Kaffman, E. R. Jolly, and E. K. O'Shea. 1996. Regulation of Pho4 nuclear localization by the Pho80-Pho85 cyclin-CDK complex. Science 271:209-212.
20. Oshima, Y. 1982 Regulatory circuits for gene expression: the metabolism of galactose and phosphate, p. 159-180. In J. N. Strathern, E. W. Jones, and J. R. Broach (ed.), The molecular biology of the yeast Saccharomyces cerevisiae: metabolism and gene expression. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
21. Rolfes, R. J., F. Zhang, and A. G. Hinnebusch. 1997. The transcriptional activators Bas1, Bas2, and Abf1 bind positive regulatory sites as the critical elements for adenine regulation of ADE5,7. J. Biol. Chem. 272:13343-13354.
22. Rudolph H., and A. Hinnen. 1987. The yeast PHO5 promoter: phosphate-control elements and sequences mediating mRNA start-site selection. Proc. Natl. Acad. Sci. USA 84:1340-1344.
23. Sarkar, G., and S. S. Sommer. 1990. The "megaprimer" method of site-directed mutagenesis. BioTechniques 8:404-407.
24. Sengstag, C., and A. Hinnen. 1988. A 28-hp segment of the Saccharomyces cerevisiae PHO5 upstream activator sequence confers phosphate control to the CYC1-lacZ gene fusion. Gene 67:223-228.
25. Shao, D., C. L. Creasy, and L. W. Bergman. 1996. Interaction of Saccharomyces cerevisiae Pho2 with Pho4 increases the accessibility of the activation domain of Pho4. Mol. Gen. Genet. 251:358-364.
26. Straka, C., and W. Hörz. 1991. A functional role for nucleosomes in the repression of a yeast promoter. EMBO J. 10:361-368.
27. Svaren, J., and W. Hörz. 1997. Transcription factors vs nucleosomes: regulation of the PHO5 promoter in yeast. Trends Biochem. Sci. 22:93-97.
28. Svaren, J., J. Schmitz, and W. Hörz. 1994. The transactivation domain of Pho4 is required for nucleosome disruption at the PHO5 promoter. EMBO J. 13:4856-4862.
29. Svaren, J., U. Venter, and W. Hörz. 1995. In vivo analysis of nucleosome structure and transcription factor binding in Saccharomyces cerevisiae. Microb. Gene Techniques 6:153-167.
30. Venter, U., J. Svaren, J. Schmitz, A. Schmid, and W. Hörz. 1994. A nucleosome precludes binding of the transcription factor Pho4 in vivo to a critical target site in the PHO5 promoter. EMBO J. 13:4848-4855.
31. Vogel, K., W. Hörz, and A. Hinnen. 1989. The two positively acting regulatory proteins PHO2 and PHO4 physically interact with PHO5 upstream activation regions. Mol. Cell. Biol. 9:2050-2057.
32. Zhang, F., M. Kirouac, N. Zhu, A. G. Hinnebusch, and R. J. Rolfes. 1997. Evidence that complex formation by Bas1p and Bas2p (Pho2p) unmasks the activation function of Bas1p in an adenine-repressible step of ADE gene transcription. Mol. Cell. Biol. 17:3272-3283.