Palladium-mediated intramolecular carbonylative annulation of o-alkynylphenols to synthesize benzo[b]furo[3,4-d]furan-1-ones

Organic Letters

Volumn 3, Issue 9, 2001, Pages 1387-1390

  Hu, Youhong ^a   Yang, Zhen ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOFURAN DERIVATIVE; PALLADIUM; PHENOL DERIVATIVE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; COMPARATIVE STUDY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BENZOFURANS; CATALYSIS; COMBINATORIAL CHEMISTRY TECHNIQUES; MOLECULAR STRUCTURE; PALLADIUM; PHENOLS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035799876     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol010033z     Document Type: Article

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41. 2 (1.0 mmol) was dissolved in dry acetonitrile (5.0 mL), and the reaction mixture was degassed by CO for 10 min and then stirred at 55 °C under a balloon pressure of CO for 12 h. The reaction mixture was concentrated and the residue was filtered through a pad of silica gel and washed by EtOAc. The filtrate was concentrated, and the residue was purified by silica gel flash chromatography.