Hepatitis C virus NS3 NTPase/helicase: Different stereoselectivity in nucleoside triphosphate utilisation suggests that NTPase and helicase activities are coupled by a nucleotide-dependent rate limiting step

Journal of Molecular Biology

Volumn 313, Issue 4, 2001, Pages 683-694

  Locatelli, Giada A ^a   Gosselin, Gilles ^b   Spadari, Silvio ^a   Maga, Giovanni ^a  

^a CNR   (Italy)

^b CNRS   (France)

Author keywords

Antiviral agents; HCV; Helicase; Hepatitis; Kinetics

Indexed keywords

2',3' DIDEHYDROTHYMIDINE TRIPHOSPHATE; 2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; ADENOSINE TRIPHOSPHATE; ANTIVIRUS AGENT; DEOXYADENOSINE TRIPHOSPHATE; DEOXYNUCLEOSIDE TRIPHOSPHATE; DIDEOXYNUCLEOSIDE TRIPHOSPHATE DERIVATIVE; HELICASE; NS3 NUCLEOSIDE TRIPHOSPHATASE; NUCLEOSIDE ANALOG; NUCLEOSIDE TRIPHOSPHATASE; NUCLEOSIDE TRIPHOSPHATE; NUCLEOTIDE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MECHANISM; HEPATITIS C VIRUS; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; REACTION ANALYSIS; STEADY STATE; STEREOCHEMISTRY;

EID: 0035798412     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5088     Document Type: Article

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