Structural determinants of HIV-1 reverse transcriptase stereoselectivity towards (β)-L-deoxy- and dideoxy-pyrimidine nucleoside triphosphates: Molecular basis for the combination of L-dideoxynucleoside analogs with non- nucleoside inhibitors in anti HIV chemotherapy

Nucleosides and Nucleotides

Volumn 18, Issue 4-5, 1999, Pages 795-805

  Maga, G ^a   Amacker, M ^b   Hubscher U ^b   Gosselin, G ^c   Imbach, J L ^c   Mathe C ^c   Faraj, A ^d   Sommadossi, J P ^d   Spadari, S ^a  

^a CNR   (Italy)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c CNRS   (France)

^d University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; LAMIVUDINE; NEVIRAPINE; NUCLEOSIDE TRIPHOSPHATE; RNA DIRECTED DNA POLYMERASE; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; BINDING SITE; CONFERENCE PAPER; CROSS RESISTANCE; CRYSTAL STRUCTURE; ENANTIOMER; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; STEREOCHEMISTRY; VIRUS MUTATION; VIRUS RESISTANCE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0033039472     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/15257779908041566     Document Type: Conference Paper

References (12)

1. Coffin, J.M. Science, 1995, 267, 483-489.
2. Larder, B.A. J. Gen. Virol., 1994, 75, 951-957.
3. Balzarini, J. and DeClercq, E. Methods Enzymol., 1996, 275, 472-503.
4. Maga, G., Amacker, M., Ruel, N., Hübscher, U. and Spadari, S. J. Mol. Biol., 1997, 242, 738-747.
5. Yamaguchi, T., Iwanami, N., Shudo, K. and Saneyoshi, M. Biochem. Biophys. Res. Commun., 1994, 200, 1023-1027.
6. Focher, F., Maga, G., Bendiscioli, A., Capobianco, M., Colonna, F., Garbesi, A. and Spadari, S. Nucl. Acids Res., 1995, 23, 2840-2847.
7. Semizarov, D.G., Arzumanov, A.A., Dyatkina, N., Meyer, A., Vichier-Guerre, S., Gosselin, G., Rayner, B., Imbach, J.-L. and Krayevsky, A.A. J. Biol. Chem., 1997, 272, 9556-9560.
8. Larder, B.A., Kemp, S.D. and Harrigan, P.R. Science, 1995, 269, 696-699.
9. Gosselin, G., Schinazi, R.F., Sommadossi, J.-P., Mathe, C., Bergogne, M.-C., Aubertine, A.-M., Kirn and Imbach, J.-L. Antimicrob. Agents Chemother., 1994 38, 1292-1297.
10. Faraj, A., Agrofoglio, L., Wakefield, J.K., McPherson, S., Morrow, C.D., Gosselin, G., Mathe, C., Imbach, J.-L., Schinazi, R.F. and Sommadossi J.-P. Antimicrob. Agents Chemother., 1994, 38, 2300-2305.
11. Spadari, S., Maga, G., Verri, A. and Focher, F. Exp. Opin. Invest. Drugs, 1998, 7, 1285-1300.
12. Ren, J., Esnouf, R., Garman, E., Somers, D., Ross, C., Kirby, I., Keeling, J., Darby, G., Jones, Y., Stuart, D. and Stammers, D. Nature Struct. Biol., 1995, 2, 293-302.