메뉴 건너뛰기




Volumn 477, Issue 1-2, 2001, Pages 71-78

Analysis of MTH1 gene function in mice with targeted mutagenesis

Author keywords

8 Oxo dGTPase; MTH1 gene; Oxidative DNA damage

Indexed keywords

8 OXO 7,8 DIHYDRO 2' DEOXYGUANOSINE 5' TRIPHOSPHATE; GUANOSINE TRIPHOSPHATE; LIVER EXTRACT; UNCLASSIFIED DRUG;

EID: 0035796027     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(01)00108-7     Document Type: Article
Times cited : (38)

References (45)
  • 1
    • 0025160599 scopus 로고
    • Modification of DNA bases in mammalian chromatin by radiation-generated free radicals
    • Gajewski E., Rao G., Nackerdien Z., Dizdaroglu M. Modification of DNA bases in mammalian chromatin by radiation-generated free radicals. Biochemistry. 29:1990;7876-7882.
    • (1990) Biochemistry , vol.29 , pp. 7876-7882
    • Gajewski, E.1    Rao, G.2    Nackerdien, Z.3    Dizdaroglu, M.4
  • 2
    • 0028342951 scopus 로고
    • Repair of oxidative damage to DNA: Enzymology and biology
    • Demple B., Harrison L. Repair of oxidative damage to DNA: enzymology and biology. Annu. Rev. Biochem. 63:1994;915-948.
    • (1994) Annu. Rev. Biochem. , vol.63 , pp. 915-948
    • Demple, B.1    Harrison, L.2
  • 3
    • 0025902273 scopus 로고
    • Endogenous mutagens and the causes of ageing and cancer
    • Ames B.N., Gold L.S. Endogenous mutagens and the causes of ageing and cancer. Mutation Res. 250:1991;3-16.
    • (1991) Mutation Res. , vol.250 , pp. 3-16
    • Ames, B.N.1    Gold, L.S.2
  • 4
    • 0021737541 scopus 로고
    • Formation of 8-hydroxyguanine residues in DNA by X-irradiation
    • Kasai H., Tanooka H., Nishimura S. Formation of 8-hydroxyguanine residues in DNA by X-irradiation. Gann. 75:1984;1037-1039.
    • (1984) Gann , vol.75 , pp. 1037-1039
    • Kasai, H.1    Tanooka, H.2    Nishimura, S.3
  • 5
    • 0002738322 scopus 로고
    • Formation of 8-hydroxy-deoxyguanosine in DNA by oxygen radicals and its biological significance
    • In: H. Sies (Ed.), Academic Press, London
    • H. Kasai, S. Nishimura, Formation of 8-hydroxy-deoxyguanosine in DNA by oxygen radicals and its biological significance, In: H. Sies (Ed.), Oxidative Stress: Oxidants and Antioxidants, Academic Press, London, 1991, pp. 99-116.
    • (1991) Oxidative Stress: Oxidants and Antioxidants , pp. 99-116
    • Kasai, H.1    Nishimura, S.2
  • 6
    • 0027324378 scopus 로고
    • Mutagenesis by 8-oxoguanine: An enemy within
    • Grollman A.P., Moriya M. Mutagenesis by 8-oxoguanine: an enemy within. Trends Genet. 9:1993;246-249.
    • (1993) Trends Genet. , vol.9 , pp. 246-249
    • Grollman, A.P.1    Moriya, M.2
  • 7
    • 0025981359 scopus 로고
    • Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxoG
    • Shibutani S., Takeshita M., Grollman A.P. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxoG. Nature. 349:1991;431-434.
    • (1991) Nature , vol.349 , pp. 431-434
    • Shibutani, S.1    Takeshita, M.2    Grollman, A.P.3
  • 8
    • 0026513966 scopus 로고
    • MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis
    • Maki H., Sekiguchi M. MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis. Nature. 355:1992;273-275.
    • (1992) Nature , vol.355 , pp. 273-275
    • Maki, H.1    Sekiguchi, M.2
  • 9
    • 0027368923 scopus 로고
    • Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis
    • Sakumi K., Furuichi M., Tsuzuki T., Kakuma T., Kawabata S., Maki H., Sekiguchi M. Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis. J. Biol. Chem. 268:1993;23524-23530.
    • (1993) J. Biol. Chem. , vol.268 , pp. 23524-23530
    • Sakumi, K.1    Furuichi, M.2    Tsuzuki, T.3    Kakuma, T.4    Kawabata, S.5    Maki, H.6    Sekiguchi, M.7
  • 10
    • 0028858586 scopus 로고
    • Mouse MTH1 protein with 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphatase activity that prevents transversion mutation
    • Kakuma K., Nishida J., Tsuzuki T., Sekiguchi M. Mouse MTH1 protein with 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphatase activity that prevents transversion mutation. J. Biol. Chem. 270:1995;25942-25948.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25942-25948
    • Kakuma, K.1    Nishida, J.2    Tsuzuki, T.3    Sekiguchi, M.4
  • 11
    • 0028826044 scopus 로고
    • CDNA and genomic sequences for rat 8-oxo-dGTPase that prevents occurrence of spontaneous mutations due to oxidation of guanine nucleotides
    • Cai J.-P., Kakuma T., Tsuzuki T., Sekiguchi M. cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents occurrence of spontaneous mutations due to oxidation of guanine nucleotides. Carcinogenesis. 16:1995;2343-2350.
    • (1995) Carcinogenesis , vol.16 , pp. 2343-2350
    • Cai, J.-P.1    Kakuma, T.2    Tsuzuki, T.3    Sekiguchi, M.4
  • 12
    • 0023131695 scopus 로고
    • Molecular cloning and nucleotide sequence of the mutT mutator of Escherichia coli that causes A:T to C:G transversion
    • Akiyama M., Horiuchi T., Sekiguchi M. Molecular cloning and nucleotide sequence of the mutT mutator of Escherichia coli that causes A:T to C:G transversion. Mol. Gen. Genet. 206:1987;9-16.
    • (1987) Mol. Gen. Genet. , vol.206 , pp. 9-16
    • Akiyama, M.1    Horiuchi, T.2    Sekiguchi, M.3
  • 13
    • 0028365287 scopus 로고
    • Purification of the MutX protein of Streptococcus pneumoniae, a homologue of Escherichia coli mutT
    • Bullions L.C., Mejean V., Claverys J.-P., Bessman M.J. Purification of the MutX protein of Streptococcus pneumoniae, a homologue of Escherichia coli mutT. J. Biol. Chem. 269:1994;12339-12344.
    • (1994) J. Biol. Chem. , vol.269 , pp. 12339-12344
    • Bullions, L.C.1    Mejean, V.2    Claverys, J.-P.3    Bessman, M.J.4
  • 14
    • 0027385530 scopus 로고
    • Sequence and characterization of mutT from Proteus vulgaris
    • Kamath A.V., Yanofsky C. Sequence and characterization of mutT from Proteus vulgaris. Gene. 134:1993;99-102.
    • (1993) Gene , vol.134 , pp. 99-102
    • Kamath, A.V.1    Yanofsky, C.2
  • 16
    • 0033621397 scopus 로고    scopus 로고
    • Functional significance of the conserved residues for the 23-residue module among MTHI and mutT family proteins
    • Fujii Y., Shimokawa H., Sekiguchi M., Nakabeppu Y. Functional significance of the conserved residues for the 23-residue module among MTHI and mutT family proteins. J. Biol. Chem. 274:1999;38251-38259.
    • (1999) J. Biol. Chem. , vol.274 , pp. 38251-38259
    • Fujii, Y.1    Shimokawa, H.2    Sekiguchi, M.3    Nakabeppu, Y.4
  • 17
    • 0028566359 scopus 로고
    • Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion
    • Furuichi M., Yoshida M.C., Oda H., Tajiri T., Nakabeppu Y., Tsuzuki T., Sekiguchi M. Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion. Genomics. 24:1994;485-490.
    • (1994) Genomics , vol.24 , pp. 485-490
    • Furuichi, M.1    Yoshida, M.C.2    Oda, H.3    Tajiri, T.4    Nakabeppu, Y.5    Tsuzuki, T.6    Sekiguchi, M.7
  • 18
    • 0031012698 scopus 로고    scopus 로고
    • Organization and expression of the mouse MTH1 gene for preventing transversion mutation
    • Igarashi H., Tsuzuki T., Kakuma T., Tominaga Y., Sekiguchi M. Organization and expression of the mouse MTH1 gene for preventing transversion mutation. J. Biol. Chem. 272:1997;3766-3772.
    • (1997) J. Biol. Chem. , vol.272 , pp. 3766-3772
    • Igarashi, H.1    Tsuzuki, T.2    Kakuma, T.3    Tominaga, Y.4    Sekiguchi, M.5
  • 19
    • 0028859990 scopus 로고
    • Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic and noncomplementation
    • Rancourt D.E., Tsuzuki T., Capecchi M.R. Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic and noncomplementation. Genes Dev. 9:1995;108-122.
    • (1995) Genes Dev. , vol.9 , pp. 108-122
    • Rancourt, D.E.1    Tsuzuki, T.2    Capecchi, M.R.3
  • 20
    • 0030443140 scopus 로고    scopus 로고
    • The relevance of bacterial mutators to understanding human cancer
    • Miller J.H. The relevance of bacterial mutators to understanding human cancer. Cancer Surv. 28:1996;141-153.
    • (1996) Cancer Surv. , vol.28 , pp. 141-153
    • Miller, J.H.1
  • 21
    • 0030839865 scopus 로고    scopus 로고
    • Oxidative decay of DNA
    • Beckman K.B., Ames B.N. Oxidative decay of DNA. J. Biol. Chem. 272:1997;19633-19636.
    • (1997) J. Biol. Chem. , vol.272 , pp. 19633-19636
    • Beckman, K.B.1    Ames, B.N.2
  • 22
    • 0030662273 scopus 로고    scopus 로고
    • Human cancer syndromes: Clues to the origin and nature of cancer
    • Fearon E.R. Human cancer syndromes: clues to the origin and nature of cancer. Science. 278:1997;1043-1050.
    • (1997) Science , vol.278 , pp. 1043-1050
    • Fearon, E.R.1
  • 23
    • 0001352834 scopus 로고    scopus 로고
    • On the origin of multiple mutations in human cancers
    • Jackson A.L., Loeb L.A. On the origin of multiple mutations in human cancers. Semin. Cancer Biol. 8:1998;421-429.
    • (1998) Semin. Cancer Biol. , vol.8 , pp. 421-429
    • Jackson, A.L.1    Loeb, L.A.2
  • 24
    • 0031980388 scopus 로고    scopus 로고
    • Role of oxidative DNA damage in cancer initiation and promotion
    • Poulsen H.E., Prieme H., Loft S. Role of oxidative DNA damage in cancer initiation and promotion. Eur. J. Cancer Prev. 7:1998;9-16.
    • (1998) Eur. J. Cancer Prev. , vol.7 , pp. 9-16
    • Poulsen, H.E.1    Prieme, H.2    Loft, S.3
  • 25
    • 0029924267 scopus 로고    scopus 로고
    • Molecular epidemiology: Insights into cancer susceptibility, risk assessment, and prevention
    • Perera F.P. Molecular epidemiology: insights into cancer susceptibility, risk assessment, and prevention. J. Natl. Cancer Inst. 88:1996;496-509.
    • (1996) J. Natl. Cancer Inst. , vol.88 , pp. 496-509
    • Perera, F.P.1
  • 26
    • 0028927316 scopus 로고
    • Generation and elimination of 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphate, a mutagenic substrate for DNA synthesis, in human cells
    • Hayakawa H., Taketomi A., Sakumi K., Kuwano M., Sekiguchi M. Generation and elimination of 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphate, a mutagenic substrate for DNA synthesis, in human cells. Biochemistry. 34:1995;89-95.
    • (1995) Biochemistry , vol.34 , pp. 89-95
    • Hayakawa, H.1    Taketomi, A.2    Sakumi, K.3    Kuwano, M.4    Sekiguchi, M.5
  • 27
    • 0027285475 scopus 로고
    • Ubiquitous somatic mutations in simple repeated sequences reveals a new mechanism for colonic carcinogenesis
    • Ionov Y., Peinado M.A., Malkhosyan S., Shibata D., Perucho M. Ubiquitous somatic mutations in simple repeated sequences reveals a new mechanism for colonic carcinogenesis. Nature. 363:1993;558-561.
    • (1993) Nature , vol.363 , pp. 558-561
    • Ionov, Y.1    Peinado, M.A.2    Malkhosyan, S.3    Shibata, D.4    Perucho, M.5
  • 28
    • 0029947527 scopus 로고    scopus 로고
    • A novel positive detection system of in vivo mutations in rpsL (strA) transgenic mice
    • Gondo Y., Shioyama Y., Nakao K., Katsuki M. A novel positive detection system of in vivo mutations in rpsL (strA) transgenic mice. Mutation Res. 360:1996;1-14.
    • (1996) Mutation Res. , vol.360 , pp. 1-14
    • Gondo, Y.1    Shioyama, Y.2    Nakao, K.3    Katsuki, M.4
  • 29
    • 0033065391 scopus 로고    scopus 로고
    • Inhibition of benso(a)pyrene-induced mutagenesis by (-)-epigallocatechin gallate in lung of rpsL transgenic mice
    • Mutoh S., Yokoi T., Gondo Y., Katsuki M., Shioyama Y., Fujita K., Kamataki T. Inhibition of benso(a)pyrene-induced mutagenesis by (-)-epigallocatechin gallate in lung of rpsL transgenic mice. Carcinogenesis. 20:1999;421-424.
    • (1999) Carcinogenesis , vol.20 , pp. 421-424
    • Mutoh, S.1    Yokoi, T.2    Gondo, Y.3    Katsuki, M.4    Shioyama, Y.5    Fujita, K.6    Kamataki, T.7
  • 30
    • 0034040923 scopus 로고    scopus 로고
    • Different mutaion frequencies and spectra among organs by N-methyl-N-nitrosourea in rpsL (strA) transgenic mice
    • Shioyama Y., Gondo Y., Nakao K., Katsuki M. Different mutaion frequencies and spectra among organs by N-methyl-N-nitrosourea in rpsL (strA) transgenic mice. Jpn. J. Cancer Res. 91:2000;482-491.
    • (2000) Jpn. J. Cancer Res. , vol.91 , pp. 482-491
    • Shioyama, Y.1    Gondo, Y.2    Nakao, K.3    Katsuki, M.4
  • 31
    • 0027171181 scopus 로고
    • Evidence for two repair enzymes for 8-hydroxyguanin (7,8-dihydro-8-oxoguanine) in human cells
    • Bessho T., Tano K., Kasai H., Ohtsuka E., Nishimura S. Evidence for two repair enzymes for 8-hydroxyguanin (7,8-dihydro-8-oxoguanine) in human cells. J. Biol. Chem. 268:1993;19416-19421.
    • (1993) J. Biol. Chem. , vol.268 , pp. 19416-19421
    • Bessho, T.1    Tano, K.2    Kasai, H.3    Ohtsuka, E.4    Nishimura, S.5
  • 32
    • 0032533794 scopus 로고    scopus 로고
    • The presence of two distinct 8-oxoguanine repair enzymes in human cells: Their potential complementary roles in preventing mutation
    • Hazra T.K., Izumi T., Maidt L., Floyd R.A., Mitra S. The presence of two distinct 8-oxoguanine repair enzymes in human cells: their potential complementary roles in preventing mutation. Nucleic Acids Res. 26:1998;5116-5122.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 5116-5122
    • Hazra, T.K.1    Izumi, T.2    Maidt, L.3    Floyd, R.A.4    Mitra, S.5
  • 34
    • 0033197818 scopus 로고    scopus 로고
    • MSH2 and MSH6 are required for removal of adenine misincorporated opposite 8-oxo-guanine in S. cerevisiae
    • Ni T.T., Marsischky G.T., Kolodner R.D. MSH2 and MSH6 are required for removal of adenine misincorporated opposite 8-oxo-guanine in S. cerevisiae. Mol. Cell. 4:1999;439-444.
    • (1999) Mol. Cell , vol.4 , pp. 439-444
    • Ni, T.T.1    Marsischky, G.T.2    Kolodner, R.D.3
  • 35
    • 0030745912 scopus 로고    scopus 로고
    • In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in xeroderma pigmentosum patients
    • Reardon J.T., Bessho T., Kung H.C., Bolton P.H., Sancar A. In vitro repair of oxidative DNA damage by human nucleotide excision repair system: possible explanation for neurodegeneration in xeroderma pigmentosum patients. Proc. Natl. Acad. Sci. U. S. A. 94:1997;9463-9468.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 9463-9468
    • Reardon, J.T.1    Bessho, T.2    Kung, H.C.3    Bolton, P.H.4    Sancar, A.5
  • 36
    • 0034654256 scopus 로고    scopus 로고
    • Identification of human MutY homolog (hMYR) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria
    • Ohtsubo T., Nishioka K., Imaiso Y., Iwai S., Shimokawa H., Oda H., Fujiwara T., Nakabeppu Y. Identification of human MutY homolog (hMYR) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria. Nucleic Acids Res. 28:2000;1346-1355.
    • (2000) Nucleic Acids Res. , vol.28 , pp. 1346-1355
    • Ohtsubo, T.1    Nishioka, K.2    Imaiso, Y.3    Iwai, S.4    Shimokawa, H.5    Oda, H.6    Fujiwara, T.7    Nakabeppu, Y.8
  • 37
    • 0028226487 scopus 로고
    • DNA base modifications in renal chromatin of Wistar rats treated with renal carcinogen ferric nitrilotriacetate
    • Toyokuni S., Mori T., Dizdaroglu M. DNA base modifications in renal chromatin of Wistar rats treated with renal carcinogen ferric nitrilotriacetate. Int. J. Cancer. 57:1994;123-128.
    • (1994) Int. J. Cancer , vol.57 , pp. 123-128
    • Toyokuni, S.1    Mori, T.2    Dizdaroglu, M.3
  • 38
    • 0029133347 scopus 로고
    • Formation of 2-hydroxydeoxyadenosine triphosphate, an oxidatively damaged nucleotide, and its incorporation by DNA polymerases. Steady-state kinetics of the incorporation
    • Kamiya H., Kasai H. Formation of 2-hydroxydeoxyadenosine triphosphate, an oxidatively damaged nucleotide, and its incorporation by DNA polymerases. Steady-state kinetics of the incorporation. J. Biol. Chem. 270:1995;19446-19450.
    • (1995) J. Biol. Chem. , vol.270 , pp. 19446-19450
    • Kamiya, H.1    Kasai, H.2
  • 39
    • 0032080121 scopus 로고    scopus 로고
    • Induction of chromosomal gene mutations in Escherichia coli by direct incorporation of oxidatively damaged nucleotides. New evaluation method for mutagenesis by damaged DNA precursors in vivo
    • Inoue M., Kamiya H., Fujikawa K., Ootsuyama Y., Murata-Kamiya N., Osaki T., Yasumoto K., Kasai H. Induction of chromosomal gene mutations in Escherichia coli by direct incorporation of oxidatively damaged nucleotides. New evaluation method for mutagenesis by damaged DNA precursors in vivo. J. Biol. Chem. 273:1998;11069-11074.
    • (1998) J. Biol. Chem. , vol.273 , pp. 11069-11074
    • Inoue, M.1    Kamiya, H.2    Fujikawa, K.3    Ootsuyama, Y.4    Murata-Kamiya, N.5    Osaki, T.6    Yasumoto, K.7    Kasai, H.8
  • 40
    • 0033603344 scopus 로고    scopus 로고
    • The oxidized forms of dATP are substrates for the human mutT homologue, the hMTH1 protein
    • Fujikawa K., Kamiya H., Yakushiji H., Fujii Y., Nakabeppu Y., Kasai H. The oxidized forms of dATP are substrates for the human mutT homologue, the hMTH1 protein. J. Biol. Chem. 274:1999;18201-18205.
    • (1999) J. Biol. Chem. , vol.274 , pp. 18201-18205
    • Fujikawa, K.1    Kamiya, H.2    Yakushiji, H.3    Fujii, Y.4    Nakabeppu, Y.5    Kasai, H.6
  • 43
    • 0029101616 scopus 로고
    • Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyper-recombination and predisposition to cancer
    • de Wind N., Dekker M., Berna A., Radman M., te Riele H. Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyper-recombination and predisposition to cancer. Cell. 82:1995;321-330.
    • (1995) Cell , vol.82 , pp. 321-330
    • De Wind, N.1    Dekker, M.2    Berna, A.3    Radman, M.4    Te Riele, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.