Comparison of unilateral and bilateral intrastriatal 6-hydroxydopamine-induced axon terminal lesions: Evidence for interhemispheric functional coupling of the two nigrostriatal pathways

Journal of Comparative Neurology

Volumn 432, Issue 2, 2001, Pages 217-229

  Roedter, Alexandra ^a   Winkler, Christian ^a,b   Samii, Madjid ^a   Walter, Gerhard F ^b   Brandis, Almuth ^b   Nikkhah, Guido ^a  

^a NORDSTADT HOSPITAL   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Basal ganglia; Dopamine; Neurodegeneration; Parkinson's disease; Skilled forelimb use; Stepping

Indexed keywords

OXIDOPAMINE; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR DISORDER; DOPAMINERGIC SYSTEM; FORELIMB; IMMUNOREACTIVITY; NERVE DEGENERATION; NERVE ENDING; NERVE LESION; NEUROPROTECTION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT;

ADRENERGIC AGENTS; ANIMALS; CAUDATE NUCLEUS; CORPUS STRIATUM; FEMALE; MOTOR ACTIVITY; MOTOR SKILLS; MUSCULOSKELETAL EQUILIBRIUM; OXIDOPAMINE; PARKINSON DISEASE; PRESYNAPTIC TERMINALS; PSYCHOMOTOR PERFORMANCE; PUTAMEN; RATS; RATS, SPRAGUE-DAWLEY; STRIATONIGRAL DEGENERATION; TYROSINE 3-MONOOXYGENASE;

EID: 0035795197     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/cne.1098     Document Type: Article

References (58)

1. Depletion of dopamine in the caudate nucleus but not in nucleus accumbens impairs reaction-time performance in rats
2. Complex deficits on reaction time performance following bilateral intrastriatal 6-OHDA infusion in the rat
3. Compensatory bilateral changes in dopamine turnover after striatal kainate lesion
4. Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in the rat
5. Retrograde degeneration of nigrostriatal neurons induced by intrastriatal 6-hydroxydopamine injection in rats
6. Catecholaminergic brain stem regulatory systems
7. Nigral transplants in the rat Parkinson model: Functional limitations and strategies to enhance nigrostriatal reconstruction
8. Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease
9. 3H]neurotensin binding by unilateral intrastriatal 6-hydroxydopamine injections: Evidence from a receptor autoradiographic study
10. Longterm behavioral and biochemical effects of 6-hydroxydopamine injections in rat caudate-putamen
11. Depletion of unilateral striatal dopamine impairs initiation of contralateral actions and not sensory attention
12. Dopamine depletion in neonatal rats: Effects on behavior and striatal dopamine release assessed by intracerebral microdialysis during adulthood
13. Effects of unilateral electrical stimulation of various thalamic nuclei on the release of dopamine from dendrites and nerve terminals of neurons of the two nigrostriatal dopaminergic pathways
14. Different effects of nucleus accumhens and ventrolateral striatal dopamine depletions on instrumental response selection in the rat
15. Effects of naloxone on dopamine release in the nigrostriatal system
16. Prospects for new restorative and neuroprotective treatments in Parkinson's disease
17. The functional role of mesotelencephalic dopamine systems
18. Intracerebral grafting of neuronal cell suspensions. V. Behavioural recovery in rats with bilateral 6-OHDA lesions following implantation of nigral cell suspensions
19. Pathogenesis and preclinical course of Parkinson's disease
20. Dopamine release and uptake rates both decrease in the partially denervated striatum in proportion to the loss of dopamine terminals
21. Role of the thalamus in the bilateral regulation of dopaminergic and GABAergic neurons in the basal ganglia
22. Partial lesions of the dopaminergic nigrostriatal system in rat brain: Biochemical characterization
23. Degeneration of the nigral dopamine neurons after 6-hydroxydopamine injection into the rat striatum
24. Biochemical and immunocytochemical changes induced by intrastriatal 6-hydroxydopamine injection in the rat nigrostriatal dopamine neuron system: Evidence for cell death in the substantia nigra
25. Post mortem studies in Parkinson's disease - Is it possible to detect brain areas for specific symptoms?
26. Chemical neurotoxins as denervation tools in neurobiology
27. Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat
28. Parkinson's disease. First of two parts
29. Parkinson's disease. Second of two parts
30. Dopaminergic neuronal degeneration and motor impairments following axon terminal lesion by instrastriatal 6-hydroxydopamine in the rat
31. Blockade by frontocortical lesion of reciprocal regulation between the two nigrostriatal dopaminergic pathways
32. Rats with partial striatal dopamine depletions exhibit robust and long-lasting behavioral deficits in a simple fixed-ratio bar-pressing task
33. The 'staircase test': A measure of independent forelimb reaching and grasping abilities in rats
34. Behavioural recovery of rats grafted with dopamine cells after partial striatal dopaminergic depletion in a conditioned reaction-time task
35. Interdependence of the nigrostriatal dopaminergic systems on the two sides of the brain in the cat
36. Restoration of complex sensorimotor behavior and skilled forelimb use by a modified nigral cell suspension transplantation approach in the rat Parkinson model
37. Improved graft survival and striatal reinnervation by microtransplantation of fetal nigral cell suspensions in the rat Parkinson model
38. Dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-OHDA lesions. II. Transplant-induced behavioral recovery
39. Differences in acquisition and full performance in skilled forelimb use as measured by the "staircase test" in five rat strains
40. Forelimb akinesia in the rat Parkinson model: Differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test
41. The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method
42. Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by intrastriatal injection of 6-hydroxydopamine
43. Interhemispheric regulation of dopaminergic ascending systems
44. Complex sensorimotor behavioral changes after terminal striatal 6-OHDA lesion and transplantation of dopaminergic embryonic micrografts
45. Distinct commissural pathways are involved in tire enhanced release of dopamine induced in the contralateral caudate nucleus and substantia nigra by unilateral application of GABA in the cat thalamic motor nuclei
46. Intrastriatal glial cell line-derived neurotrophic factor promotes sprouting of spared nigrostriatal dopaminergic afferents and induces recovery of function in a rat model of Parkinson's disease
47. Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle
48. Ventrolateral striatal dopamine depletions impair feeding and food handling in rats
49. Are bilateral nigrostriatal dopaminergic pathways functionally linked in the rat brain? A microdialysis study in conscious rats
50. Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat
51. Intracerebral grafting of neuronal cell suspensions. III. Activity of intrastriatal nigral suspension implants as assessed by measurements of dopamine synthesis and metabolism
52. Neurochemical changes in the substantiae nigrae and caudate nuclei following acute unilateral intranigral infusions of N-methyl-4-phenyl-1.2,3.6-tetrahydropyridine (MPTP)
53. Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system
54. The contributions of motor cortex, nigrostriatal dopamine and caudate-putamen to skilled forelimb use in the rat
55. Short-term GDNF treatment provides long-term rescue of lesioned nigral dopamine neurons in a rat model of Parkinson's disease
56. Intranigral transplants of GABA-rich striatal tissue induce behavioral recovery in the rat Parkinson model and promote the effects obtained by intrastriatal dopaminergic transplants
57. Influence of 6-hydroxydopamine lesion of the dopaminergic nigrostriatal pathway on the muscle tone and electromyographic activity measured during passive movements