Catalytic efficiency and sequence selectivity of a restriction endonuclease modulated by a distal manganese ion binding site

Journal of Molecular Biology

Volumn 306, Issue 4, 2001, Pages 851-861

  Sam, My D ^a   Horton, Nancy C ^a   Nissan, T Amar ^a   Perona, John J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Indirect readout; Metal ion catalysis; Protein engineering; Protein nucleic acid recognition

Indexed keywords

CALCIUM ION; DNA; MANGANESE; RESTRICTION ENDONUCLEASE;

ARTICLE; BINDING SITE; CATALYSIS; CRYSTAL STRUCTURE; DNA SEQUENCE; ENZYME BINDING; ENZYME KINETICS; ENZYME SUBUNIT; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN NUCLEIC ACID INTERACTION; SEQUENCE ANALYSIS; STEADY STATE;

EID: 0035793706     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4434     Document Type: Article

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