The expression of GABA(A) receptor α2 subunit is upregulated by testosterone in rat cerebral cortex

Neuroscience Letters

Volumn 265, Issue 1, 1999, Pages 25-28

  Zhang, Lei ^a   Chang, Yoong H ^b   Feldman, Aaron N ^a   Ma, Wu ^b   Lahjouji, F ^b   Barker, Jeffery L ^b   Hu, Qain ^b   Maric, Dragan ^b   Li, Bing Sheng ^c   Li, Wen ^b   Rubinow, David R ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Cortex; GABA; In situ hybridization; mRNA; Testosterone

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; TESTOSTERONE;

ALPHA CHAIN; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN MATURATION; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; FEMALE; GABAERGIC SYSTEM; IN SITU HYBRIDIZATION; NEUROMODULATION; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; SEX DIFFERENCE; WESTERN BLOTTING;

EID: 0033537919     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00193-7     Document Type: Article

References (25)

1. Altman, J. and Bayer, S.A., Atlas of prenatal rat brain development, CRC Press, Boca Raton, FL, 1995.
2. Bach F., Flugge G., Wuttke W. GABAergic influence on the development of the sexually dimorphic nucleus of male and female rats. Brain Res. 573:1992;341-444.
3. Bar-Ami S., Amiri Z., Weizman A., Fares F., Gavish M. Long-term testosterone or diethylastilbestrol treatment affects gamma-aminobutyric acid and central-type benzodiazepine receptors but not peripheral-type benzodiazepine receptors in the female rat brain. Neuroendocrinology. 57:1993;1114-1118.
4. Baum M.J. Frank Beach's research on the sexual differentiation of behavior and his struggle with the 'organizational' hypothesis. Neurosci. Biobehav. Rev. 14:1990;201-206.
5. Beatty W.W. Gonadal hormones and sex differences in nonreproductive behaviors in rodents: organizational and activational influence. Horm. Behav. 12:1979;112-163.
6. A receptor in the rat. Horm. Behav. 27:1993;568-583.
7. Breedlove S.M., Arnold A.P. Sex differences in the pattern of steroid accumulation by motoneurons of the rat lumbar spinal cord. J. Comp. Neurol. 215:1983;211-216.
8. Canonaco M., Tavolaro R., Cerra M.C., Anastasio M., Franzoni M.F. Gonadal regulation of GABA receptors in the different brain areas of the male Japanese quail. Exp. Brain Res. 87:1991;634-640.
9. Earley C.J., Leonard B.E. The effect of testosterone and cyproterone acetate on the concentration of gamma-aminobutyric acid in brain areas of aggressive and non-aggressive mice. Pharmacol. Biochem. Behav. 6:1977;409-413.
10. Grattan D.R., Selmanoff M. Castration-induced decrease in the activity of medial preoptic and tuberoinfundibular GABAergic neurons is prevented by testosterone. Neuroendocrinology. 60:1994;141-149.
11. Houtsmuller E.J., De Jong F.H., Rowland D.L., Slob A.K. Plasma testosterone in fetal rats and their mothers on day 19 of gestation. Physiol. Behav. 57:1995;495-499.
12. Kellogg C.K., Primus R.J., Bitran D. Sexually dimorphic influence of prenatal exposure to diazepam on behavioral response to environmental challenge and on γ-aminobutyric acid (GABA)-stimulated chloride uptake in the brain. J. Pharmacol. Exp. Ther. 256:1991;259-265.
13. Kostowski W. Recent advance in the GABA-A-benzodiazepine receptor pharmacology. Pol. J. Pharmacol. 47:1995;237-246.
14. Lasaga M., Duvianski B.H., Seilicovich A., Afione S., Debeljuk L. Effect of sex steroids on GABA receptors in the rat hypothalamus and anterior pituitary gland. Eur. J. Pharmacol. 155:1988;163-166.
15. Lauder J.M. Neurotransmitters as growth regulatory signals: role of receptors and second messangers. Trends Neurosci. 16:1993;233-239.
16. A receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development. J. Neurosci. 12:1992;4151-4172.
17. A receptor heterogeneity. Nature. 335:1988;76-79.
18. A receptor in rat brain. FEBS Lett. 260:1990;261-265.
19. McEwen, B.S., Steroid hormones: effect on brain development and function, Horm. Res., 3 (1992) (Suppl.) 1-10.
20. A receptor function. Adv. Biochem. Psychopharmacol. 47:1992;87-92.
21. Rosse R.B., Mastropaolo J., Novitzki M.R., Deutsch S.I. Depot testosterone attenuates the anticonvulsant effect of flurazepam in mice. Psychoneuroendocrinology. 15:1990;83-85.
22. Sherwood, N. and Timiras, P.S., A stereotaxic atlas of the developing rat brain, University of California Press, Berkeley, CA, 1970.
23. Trudeau V.L., Sloley B.D., Peter R.E. Testosterone enhances GABA and taurine but not N-methyl-D, L-aspartate stimulation of gonadotropin secretion in the goldfish: possible sex steroid feedback mechanisms. J. Neuroendocrinol. 5:1993;129-136.
24. Wilson M.A., Biscardi R. Influence of gender and brain region on neurosteroid modulation of GABA responses in rats. Life Sci. 60:1997;1679-1691.
25. Zhang L., Rubinow D.R., Ma W., Marks J.M., Feldman A.N., Barker J.L., Tatham T.A. GABA receptor subunit mRNA expression in brain of conflict, yoked control and control rats. Mol. Brain Res. 58:1998;16-26.