Noxious heat-induced CGRP release from rat sciatic nerve axons in vitro

European Journal of Neuroscience

Volumn 14, Issue 8, 2001, Pages 1203-1208

  Sauer, Susanne K ^a   Reeh, P W ^a   Bove, G M ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Calcium dependency; Capsaicin; Capsazepine; Ruthenium Red; Vanilloid receptor

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CALCIUM ION; CAPSAICIN; CAPSAZEPINE; ION CHANNEL; IONOTROPIC RECEPTOR; NEUROPEPTIDE; POTASSIUM; RUTHENIUM RED; VANILLOID RECEPTOR;

ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; EXCITATION; HEAT; HEAT SENSITIVITY; MALE; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; REGULATORY MECHANISM; SCIATIC NERVE; TEMPERATURE DEPENDENCE; THERMAL STIMULATION;

ANIMALS; AXONS; CALCITONIN GENE-RELATED PEPTIDE; CAPSAICIN; COLORING AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIA, SPINAL; HEAT; MALE; NOCICEPTORS; PAIN; POTASSIUM; RATS; RATS, WISTAR; RECEPTORS, DRUG; RUTHENIUM RED; SCIATIC NERVE;

EID: 0035783469     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0953-816X.2001.01741.x     Document Type: Article

References (32)

1. Bretag, A.H. (1969) Synthetic interstitial fluid for isolated mammalian tissue. Life Sci., 8, 319-329.
2. Caterina, M.J., Leffler, A., Malmberg, A.B., Martin, W.J., Trafton, J., Petersen-Zeitz, K.R., Koltzenburg, M., Basbaum, A.I. & Julius, D. (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science, 288, 306-313.
3. Caterina, M.J., Rosen, T.A., Tominaga, M., Brake, A.J. & Julius, D. (1999) A capsaicin-receptor homologue with a high threshold for noxious heat. Nature, 398, 436-441.
4. Cesare, P. & McNaughton, P. (1996) A novel heat-activated current in nociceptive neurons, and its sensitization by bradykinin. Proc. Natl Acad. Sci. USA, 93, 15435-15439.
5. Davis, J.B., Gray, J., Gunthorpe, M.J., Hatcher, J.P., Davey, P.T., Overend, P., Harries, M.H., Latcham, J., Clapham, C., Atkinson, K., Hughes, S.A., Rance, K., Grau, E., Harper, A.J., Pugh, P.L., Rogers, D.C., Bingham, S., Randall, A. & Sheardown, S.A. (2000) Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature, 405, 183-187.
6. De-Camilli, P. & Jahn, R. (1990) Pathways to regulated exocytosis in neurons. Annu. Rev. Physiol., 52, 625-645.
7. Dirig, D.M., Hua, X.Y. & Yaksh, T.L. (1997) Temperature dependency of basal and evoked release of amino acids and calcitonin gene-related peptide from rat dorsal spinal cord. J. Neurosci., 17, 4406-4414.
8. 2+-dependent exocytosis in the somata of dorsal root ganglion neurons. Neuron, 17, 135-145.
9. Jordt, S.E., Tominaga, M. & Julius, D. (2000) Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc. Natl Acad. Sci. USA, 97, 8134-8139.
10. Kessler, F., Habelt, C., Averbeck, B., Reeh, P.W. & Kress, M. (1999) Heat-induced release of CGRP from isolated rat skin and effects of bradykinin and the protein kinase C activator PMA. Pain, 83, 289-295.
11. Kirschstein, T., Greffrath, W., Busselberg, D. & Treede, R.D. (1999) Inhibition of rapid heat responses in nociceptive primary sensory neurons of rats by vanilloid receptor antagonists. J. Neurophysiol., 82, 2853-2860.
12. Kress, M., Guthmann, C., Averbeck, B. & Reeh, P.W. (1999) Calcitonin gene-related peptide and prostaglandin E2 but not substance P release induced by antidromic nerve stimulation from rat skin, in vitro. Neuroscience, 89, 303-310.
13. Lewis, T. (1937) The nocifensor system of nerves and its reactions. Br. Med. J., 1, 431-435; 491-494.
14. Li, J.-Y., Jahn, R. & Dahlström, A. (1994) Synaptotagmin I is present mainly in autonomic and sensory neurons of the rat peripheral nervous system. Neuroscience, 63, 837-850.
15. Lopshire, J.C. & Nicol, G.D. (1998) The cAMP transduction cascade mediates the prostaglandin E2 enhancement of the capsaicin-elicited current in rat sensory neurons: Whole-cell and single-channel studies. J. Neurosci., 18, 6081-6092.
16. Marsh, S.J., Stansfeld, C.E., Brown, D.A., Davey, R. & McCarthy, D. (1987) The mechanism of action of capsaicin on sensory C-type neurons and their axons in vitro. Neuroscience, 23, 275-289.
17. Michaelis, M., Vogel, C., Blenk, K.H. & Janig, W. (1997) Algesics excite axotomised afferent nerve fibres within the first hours following nerve transection in rats. Pain, 72, 347-354.
18. Nagy, I. & Rang, H.P. (1999) Similarities and differences between the responses of rat sensory neurons to noxious heat and capsaicin. J. Neurosci., 19, 10647-10655.
19. Osaka, T., Kobayashi, A., Namba, Y., Ezaki, O., Inoue, S., Kimura, S. & Hee Lee, T. (1998) Temperature- and capsaicin-sensitive nerve fibers in brown adipose tissue attenuate thermogenesis in the rat. Pflügers Arch., 437, 36-42.
20. Osborne, S.L., Herreros, J., Bastiaens, P.I. & Schiavo, G. (1999) Calcium-dependent oligomerization of synaptotagmins I and II. Synaptotagmins I and II are localized on the same synaptic vesicle and heterodimerize in the presence of calcium. J. Biol. Chem., 274, 59-66.
21. Reeh, P.W. & Pethö, G. (2000) Nociceptor excitation by thermal sensitization-a hypothesis. Prog. Brain Res., 129, 39-50.
22. Saria, A. & Lundberg, J.M. (1983) Capsaicin pretreatment inhibits heat-induced oedema in the rat skin. Naunyn Schmiedebergs Arch. Pharmacol., 323, 341-342.
23. Sauer, S.K., Bove, G.M., Averbeck, B. & Reeh, P.W. (1999a) Rat peripheral nerve components release calcitonin gene-related peptide and prostaglandin E2 in response to noxious stimuli: Evidence that nervi nervorum are nociceptors. Neuroscience, 92, 319-325.
24. Sauer, S.K., Bove, G.M. & Reeh, P.W. (1999b) Heat-induced CGRP release from rat sciatic nerve fibers, in vitro. Soc. Neurosci Abstr., 25, 683.
25. Savidge, J.R., Ranasinghe, S.P. & Rang, H.P. (2001) Comparison of intracellular calcium signals evoked by heat and capsaicin in cultured rat dorsal root ganglion neurons and in a cell line expressing the rat vanilloid receptor, VR1. Neuroscience, 102, 177-184.
26. Thureson, K.A. & Klein, R.L. (1990) Exocytosis from large dense-cored vesicles. Int. Rev. Cytol., 121, 67-126.
27. Tominaga, M., Caterina, M.J., Malmberg, A.B., Rosen, T.A., Gilbert, H., Skinner, K., Raumann, B.E., Basbaum, A.I. & Julius, D. (1998) The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron, 21, 531-543.
28. Vyklicky, L., Vlachova, V., Vitaskova, Z., Dittert, I., Kabat, M. & Orkand, R.K. (1999) Temperature coefficient of membrane currents induced by noxious heat in sensory neurones in the rat. J. Physiol. (Lond.), 517, 181-192.
29. 2+ transients in unmyelinated nerve fibres of the isolated adult rat vagus nerve. Pflügers Arch., 435, 678-686.
30. Welk, E., Petsche, U., Fleischer, E. & Handwerker, H.O. (1983) Altered excitability of afferent C-fibres of the rat distal to a nerve site exposed to capsaicin. Neurosci. Lett., 38, 245-250.
31. Zimmermann, M. & Sanders, K.H. (1982) Responses of nerve axons and receptor endings to heat, ischemia, and algesic substances. Abnormal excitability of regenerating nerve endings. In Culp, W.J. & Ochoa, J. (eds), Abnormal Nerves and Muscles as Impuls Generators. Oxford University Press, New York, Oxford. pp. 513-532.
32. Zochodne, D.W. & Ho, L.T. (1992) Hyperemia of injured peripheral nerve: Sensitivity to CGRP antagonism. Surg. Neurol., 598, 66.