Expression of human Pit-1 product in the human pituitary and pituitary adenomas: Immunohistochemical studies using an antibody against synthetic human Pit-1 product

Archives of Pathology and Laboratory Medicine

Volumn 120, Issue 1, 1996, Pages 73-77

  Sanno, Naoko ^a   Teramoto, Akira ^b   Matsuno, Akira ^c   Osamura, R Yoshiyuki ^a  

^a TOKAI UNIVERSITY   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; DNA BINDING PROTEIN; GROWTH HORMONE; SYNTHETIC PEPTIDE; THYROTROPIN; TRANSCRIPTION FACTOR;

ACROMEGALY; ADOLESCENT; ADULT; AGED; ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CLINICAL FEATURE; CONTROLLED STUDY; CUSHING DISEASE; FEMALE; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; HYPOPHYSIS CELL; MAJOR CLINICAL STUDY; MALE; PROLACTINOMA; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN INDUCTION;

EID: 0030045558     PISSN: 00039985     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Gicquel C, Lebouc Y, Luton J-P, et al. Monoclonality of corticotroph macroadenomas in Cushing's disease. J Clin Endocrinol Metab. 1992;75:472-475.
2. Herman V, Fagin J, Consky R, et al. Clonal origin of pituitary adenomas. J Clin Endocrinol Metab. 1990;71:1427-1433.
3. Alexander JM, Biler BMK, Bikkal H, et al. Clinically nonfunctioning pituitary tumors are monoclonal in origin. J Endocrinol Invest. 1990;86:336-340.
4. Landis CA, Masters SB, Spada A, et al. GTPase inhibiting mutations activate the a chain of Gs and stimulate adenylyl cyclase in human pituitary tumors. J Clin Endocrinol Metab. 1989;74:914-919.
5. Karga HJ, Alexander JM, Hedley-White ET, et al. Ras mutations in human pituitary tumors. J Clin Endocrinol Metab. 1992;74:914-919.
6. Pei L, Melmed S, Scheithauer B, et al. H-ras mutations in human pituitary carcinoma metastases. J Clin Endocrinol Metab. 1994;78:842-846.
7. Herman V, Drazin NZ, Gonsky R, et al. Molecular screening of pituitary adenomas for gene mutations and rearrangements. J Clin Endocrinol Metab. 1993;77:50-55.
8. Woloschak M, Roberts JL, Post K. c-Myc, c-fos, and c-myb gene expression in human pituitary adenomas. J Clin Endocrinol Metab. 1994;79:253-257.
9. Bodner M, Castrillo J-L, Theill LE, et al. The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein. Cell. 1988;55:505-518
10. Ingraham HA, Chen R, Mangalam HJ, et al. A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype. Cell. 1988;55: 519-529.
11. Li S, Crenshaw EB, Rawson EJ, et al. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene Pit-1. Nature. 1990;347:528-533.
12. Mangalam HJ, Albert VR, Ingraham HA, et al. A pituitary POU-domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally. Genes Dev. 1989;3:946-958.
13. Simmons DW, Voss JW, Ingraham HA, et al. Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other transcription factors. Genes Dev. 1990;4:695-711.
14. Dolle P, Castrillo J-L, Theill LE, et al. Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity. Cell. 1990;60:809-820.
15. Castrillo JL, Theill LE, Karin M. Function of the homeodomain protein GHF1 in pituitary cell proliferation. Science. 1991;253:197-199.
16. Friend KE, Chiou Y-K, Laws ER, et al. Pit-1 messenger ribonucleic acid is differentially expressed in human pituitary adenomas. J Clin Endocrinol Metab. 1993;77:1281-1286.
17. Lloyd RV, Jin L, Chanler WF, et al. Pituitary-specific transcription factor messenger ribonucleic expression in adenomatous and nontumorous human pituitary tissues. Lab Invest. 1993;69:570-575.
18. Asa SL, Puy LA, Lew AM, et al. Cell type-specific expression of the pituitary transcription activator Pit-1 in the human pituitary and pituitary adenomas. J Clin Endocrinol Metab. 1993;77:1275-1280.
19. Pellegrini I, Barlier A, Gunz G, et al. Pit-1 gene expression in the human pituitary and pituitary adenomas. J Clin Endocrinol Metab. 1994;79:189-196.
20. Inada K, Oda K, Utsunomiya H, et al. Immunohistochemical expression of Pit-1 protein in human pituitary adenomas. Endocr Pathol. 1993;4:201-204.
21. Sanno N, Inada K, Utsunomiya H, et al. Expression of Pit-1 product in human pituitaries: histochemical studies using an antibody against synthetic human Pit-1 protein. Med Sci Res. 1994;22:685-687.
22. Hoggard N, Callanghan K, Levy A, Davis JRE. Expression of Pit-1 and related proteins in diverse human pituitary adenomas. J Molec Endocrinol. 1993;11:283-290.
23. Delhase M, Vergani P, Malur A, et al. Pit-1/GHF-1 expression in pituitary adenomas: further analogy between human adenomas and rat SMtTW tumours. J Molec Endocrinol. 1993;11:129-139.
24. Tatsumi K, Notomi T, Amino N, et al. Nucleotide sequence of the complementary DNA for human Pit-1/GHF-1. Biochem Biophys Acta. 1992;1129: 231-234.
25. Nakane PK. Simultaneous localization of multiple tissue antigens using the peroxidase-labeled antibody method: a study on pituitary glands of the rat. J Histochem Cytochem. 1968;16:557-560.
26. Lloyd RV, Jin L, Kulig E, et al. Pit-1/GHF-1 transcription factor expression in rodent pituitaries. Endocr Pathol. 1993;4:146-154.
27. Osamura RY, Oda K, Utsunomiya H, et al. Immunohistochemical expression of Pit-1 protein in pituitary glands of human GRF transgenic mice: its relationship with hormonal expression. Endocr J. 1993;40:133-139.
28. Chen R, Ingraham HA, Treacy MN, et al. Autoregulation of Pit-1 gene expression mediated by two cis-active promoter elements. Nature. 1990;346: 583-586.
29. Rhodes SJ, Chen R, DiMattia GE, et al. A tissue-specific enhancer confers Pit-1 dependent morphogen inducibility and autoregulation on the Pit-1 gene. Genes Dev. 1993;7:913-932.
30. Day RN, Koike S, Sakai M, et al. Both Pit-1 and the estrogen receptor are required for estrogen responsiveness of the rat prolactin gene. Molec Endocrinol. 1990;4:1964-1971.
31. Morris AE, Kloss B, McChesney RE, et al. An alternatively spliced Pit-1 isoform altered in its ability to transactivate. Nucleic Acids Res. 1992;20:1355-1361.
32. Theill LE, Hattori K, Lazzaro D et al. Differential splicing of the GHF1 primary transcript gives rise to two functionally distinct homeodomain proteins. EMBO J. 1992;11:2261-2269.