Molecular characterization of human monoclonal antibodies derived from fusions of tonsil lymphocytes with a human myeloma cell line

Hybridoma and Hybridomics

Volumn 20, Issue 5-6, 2001, Pages 287-292

  Vaisbourd, Marina ^a,b   Ignatovich, Olga ^c   Dremucheva, Alla ^a   Karpas, Abraham ^a   Winter, Greg ^b,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MRC CENTRE FOR PROTEIN ENGINEERING   (United Kingdom)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN MONOCLONAL ANTIBODY;

ANTIBODY RESPONSE; ARTICLE; CANCER CELL CULTURE; CELL FUSION; CELL MATURATION; CONTROLLED STUDY; DNA SEQUENCE; GERM LINE; HUMAN; HUMAN CELL; HYBRIDOMA; LYMPHOCYTE; MYELOMA CELL; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SOMATIC MUTATION; TONSIL CELL;

EID: 0035744782     PISSN: 15368599     EISSN: None     Source Type: Journal    
DOI: 10.1089/15368590152740680     Document Type: Article

References (27)

1. Continuous cultures of fused cells secreting antibody of predefined specificity
2. The dynamic nature of the antibody repertoire
3. Stable expression and somatic hypermutation of antibody V regions in B-cell developmental pathways
4. Virus neutralization by germ-line vs. hypermutated antibodies
5. Human lymphocyte hybridomas and monoclonal antibodies
6. Human monoclonal antibodies
7. Making antibody fragments using phage display libraries
8. Original and artificial antibodies
9. Antibodies from libraries
10. Human myeloma cell line carrying a Philadelphia chromosome
11. A human myeloma cell line suitable for the generation of human monoclonal antibodies
12. Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire
13. Isolation of high affinity human antibodies directly from large synthetic repertoires
14. The creation of diversity in the human immunoglobulin Vλ repertoire
15. On the interaction between single chain Fv antibodies and bacterial immunoglobulin-binding proteins
16. Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes
17. The human immunoglobulin VH repertoire
18. Representation of rearranged VH gene segments in the human adult antibody repertoire
19. κ segments reveals a strong bias in their usage
20. Pairing of variable heavy and variable κ chains in individual naïve and memory B cells
21. The imprint of somatic hypermutation on the repertoire of human germline V genes
22. An analysis of the sequences of the variable regions of Bence-Jones proteins and myeloma light-chains and their implications for antibody complementarity
23. Sequence and evolution of the human germline V lambda repertoire
24. Structural repertoire of the human VH segments
25. The structural repertoire of the human V kappa domain