Potentiation by nitric oxide synthase inhibitor and calcium channel blocker of aspartame-induced antinociception in the mouse formalin test

Fundamental and Clinical Pharmacology

Volumn 15, Issue 2, 2001, Pages 117-123

  Abdollahi, Mohammad ^a   Nikfar, Shekoufeh ^a   Abdoli, Narges ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Aspartame; Calcium channel blocker; Formalin test; Nitric oxide; Nociception

Indexed keywords

ANALGESIC AGENT; ASPARTAME; CALCIUM CHANNEL BLOCKING AGENT; CYCLIC GMP; FORMALDEHYDE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; DRUG POTENTIATION; EXPERIMENTAL TEST; MALE; MEDIATOR RELEASE; MOUSE; NONHUMAN; PAIN; PRIORITY JOURNAL; RECEPTOR UPREGULATION;

ANALGESICS; ANIMALS; ASPARTAME; CALCIUM CHANNEL BLOCKERS; DRUG SYNERGISM; ENZYME INHIBITORS; MALE; MICE; MICE, INBRED STRAINS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PAIN; PAIN MEASUREMENT; RECEPTORS, N-METHYL-D-ASPARTATE; VERAPAMIL;

EID: 0035740307     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1472-8206.2001.00013.x     Document Type: Article

References (58)

1. Role of L-type calcium channel blockers in lead acetate induced antinociception in formalin test
2. Effects of calcium channel blockers on formalin-induced nociception and inflammation in rats
3. Hyperalgesic effects of divalent cations and antinociceptive effects of a calcium chelator in na and morphine-dependent animals
4. NMDA receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurons
5. Systemic opioids do not suppress spinal sensitization after subcutaneous formalin in rats
6. Nitric oxide (NO) and nociceptive processing in the spinal cord
7. ù-nitro-L-arginine methyl ester, a nitric oxide synthesis inhibitor, on stress- and morphine-induced prolactin release in male rats
8. Endothelium-derived relaxing factor: Identification as nitric oxide and role in the control of vascular tone and platelet function
9. Activation of spinal N-methyl-D-aspartate receptors stimulates a nitric oxide/cyclic guanosine 3,5-monophosphate/glutamate release cascade in nociceptive signaling
10. Activation of cGMP-dependent protein kinase I-alpha is required for N-methyl-D-aspartate- or nitric oxide-produced spinal thermal hyperalgesia
11. Role of spinal muscarinic and nicotinic receptors in clonidine-induced nitric oxide release in a rat model of neuropathic pain
12. Intrathecal injection of corticotropin inhibited nitric oxide synthase-positive neuron increase in rat spinal cord after formalin-induced hyperalgesia
13. Inhibition of inducible nitric oxide synthase in persistent pain
14. Expression and action of cyclic GMP-dependent protein kinase I-alpha in inflammatory hyperalgesia in rat spinal cord
15. Inhibition of nitric oxide synthase has an analgesic effect in chronic pain
16. Interaction between calcium channel blockers and sweetening agents on morphine induced analgesia in mice by formalin-test
17. Morphine analgesia in the tail flick and formalin pain test is mediated by different neural systems
18. Methodological refinements to the mouse paw formalin test: An animal model of tonic pain
19. Effects of sweetening agents on morphine induced analgesia in mice by formalin test
20. The formalin test: A quantitative study of the analgesic effect of morphine, meperidine and brain stem stimulation in rats and cats
21. Modified formalin test, characteristic biphasic pain response
22. Mechanism of pain induced by radiocontrast media
23. Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat
24. Modulation of acute inflammation by endogenous nitric oxide
25. Peripheral analgesia and activation of the nitric oxide-cuclic GMP pathway
26. Antin-ociceptive effect of L-arginine on carrageenan-induced hyper-algesia in rats: Possible involvement of central opioidergic systems
27. Effect of topical administration of L-arginine on formalin-induced nociception in the mouse: A dual role of peripherally formed NO in pain modulation
28. Spatial and temporal aspects of spinal cord and brainstem activation in the formalin pain model
29. G-nitroarginine methyl ester exhibits antinociceptive activity in the mouse
30. Role of excitatory amino acid receptors in the mediation of the nociceptive response in the rat
31. Chemically-diverse ligands at the glycine B site coupled to N-methyl-D-aspartate (NMDA) receptors selectively block the late phase of formalin-induced pain in mice
32. Comparison of the antinociceptive effects of pre and posttreatment with morphine and MK801, an NMDA antagonist, on the formalin test in the rat
33. Blockade of spinal N- and P-type, but not L-type, calcium channels inhibits the excitability of rat dorsal horn neurons produced by subcutaneous formalin inflammation
34. Effects of diltiazem, a calcium channel blocker, on naloxone-precipitated changes in dopamine and its metabolites in the brains of opioid-dependent rats
35. 3H) -nitrendipine binding sites in rat spinal cord
36. The central role of voltage-activated and receptor-operated calcium channels in neuronal cells
37. Calcium channel diversity and neurotransmitter release: The ω-conotoxins and ω-agatoxins
38. Antagonist of neuronal calcium channels: Structure, function, and therapeutic implications
39. The role of NMDA receptor-operated calcium channels in persistent nociception after formalin-induced tissue injury
40. Voltage-sensitive calcium channels in spinal nociceptive processing: Blockade of N- and P-type channels inhibits formalin-induced nociception
41. Activation of hypothalamic beta-endorphin pools by reward induced by highly palatable food
42. Prenatal exposure to morphine alters analgesic responses and preference for sweet solutions in adult rats
43. Influence of intake of sweet solutions on the analgesic effect of low dose morphine in randomly bred rats
44. Effects of chronically elevated intake of different concentrations of saccharin on morphine tolerance in genetically selected rats
45. Morphine tolerance in genetically selected rats induced by chronically elevated saccharin intake
46. Effects of saccharin on morphine-induced antinociception in mice by formalin test
47. Analgesic effects of several calcium channel blockers in mice
48. Treatment of osteoartritis with aspartame
49. Comparative metabolism of aspartame in experimental animals and humans
50. Effect of aspartate and glutamate on nociception, catalepsy and core temperature in rats
51. Magnesium gates glutamate activated channels in mice central neurons
52. Contribution of central neuroplasticity to pathological pain: Review of clinical and experimental evidence
53. Binding of 2,4-dinitrophenyl compounds and other small molecules to a crystalline lambda-type Bence-Jones dimer
54. The binding of opioid peptides to the Mcg light chain dimer: Flexible keys and adjustable locks
55. Effect of aspartame on N-methyl-D-aspartate-sensitive L-[3H]glutamate binding sites in rat brain synaptic membranes
56. Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats