Activation of cGMP-dependent protein kinase Iα is required for N-methyl-D-aspartate- or nitric oxide-produced spinal thermal hyperalgesia

European Journal of Pharmacology

Volumn 392, Issue 3, 2000, Pages 141-145

  Tao, Yuan Xiang ^a   Johns, Roger A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

cGMP dependent; Hyperalgesia; N methyl D aspartate (NMDA); Nitric oxide (NO); Nociception; Pain; Protein kinase; Spinal cord

Indexed keywords

CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; DIZOCILPINE; ISOENZYME; N ETHYL 2 (1 ETHYL 2 HYDROXY 2 NITROSOHYDRAZINO)ETHANAMAINE; N METHYL DEXTRO ASPARTIC ACID; NITRIC OXIDE DONOR; NOC 12; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; HYPERALGESIA; LATENT PERIOD; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; TAIL FLICK TEST;

ANIMALS; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; HYPERALGESIA; INJECTIONS, SPINAL; MALE; N-METHYLASPARTATE; NITRIC OXIDE; NITRIC OXIDE DONORS; NITROSO COMPOUNDS; PAIN; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; THIONUCLEOTIDES;

EID: 0034737447     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00129-1     Document Type: Article

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