Prenatal exposure to morphine alters analgesic responses and preference for sweet solutions in adult rats

Pharmacology Biochemistry and Behavior

Volumn 55, Issue 4, 1996, Pages 629-634

  Gagin, R ^a   Cohen, E ^b   Shavit, Y ^b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b NONE

Author keywords

analgesia; delayed effects; morphine emulsion; nociception; opiates; palatability; prenatal; reward; saccharin; sweetness preference

Indexed keywords

MORPHINE; SACCHARIN;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; FETUS; FOOD PREFERENCE; NONHUMAN; PREGNANCY; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANALGESICS, OPIOID; ANIMALS; DELAYED-ACTION PREPARATIONS; FEMALE; FOOD PREFERENCES; MALE; MORPHINE; PAIN MEASUREMENT; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, INBRED F344; REACTION TIME; SACCHARIN; SWEETENING AGENTS; TASTE;

EID: 0030463368     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(96)00278-X     Document Type: Article

References (53)

1. 1. Behnke, M; Davis Eyler, F. The consequences of prenatal substance use for the developing fetus, newborn and young child. Int. J. Addic., 28:1341-1391; 1993.
2. 2. Belluzzi, J. D.; Stein, L. Enkephalin may mediate euphoria and drive reduction reward. Nature, 266:556-558; 1977.
3. 3. Bergmann, F.; Lieblich, I.; Cohen, E.; Ganchrow, J. R. Influence of intake of sweet solutions on the analgesic effect of a low dose of morphine in randomly bred rats. Behav. Neural Biol. 44:347-353; 1985.
4. 4. Bozarth, M. A. Opioid reinforcement processes. In: Rodgers, R. J.; Cooper, S. J., eds. Endorphines, opiates and behavioural processes. New York: John Wiley and Sons; 1988:53-75.
5. 5. Castellano, C.; Ammassari-Teule, M. Prenatal exposure to morphine in mice: Enhanced responsiveness to morphine and stress. Pharmacol. Biochem. Behav. 21:103-108; 1984.
6. 6. Chasnoff, I. J.; Hatcher, R.; Burns, W. J. Polydrug and methadone addicted newborns: A continuum or impairment? Pediatrics, 70: 210-213; 1982.
7. 7. Cohen, E.; Lieblich, I.; Bergmann, F. Effects of chronically elevated intake of different concentrations of saccharine on morphine tolerance in genetically selected rats. Physiol. Behav. 32:1041-1043; 1984.
8. 8. Collier, H. O. J.; Francis, D. L.; Schneider, C. Modification of morphine withdrawal by drugs interacting with humoral mechanisms: Some contradictions and their interpretation. Nature, 237: 220-223; 1972.
9. 9. Cooper, S. J.; Kirkham, T. C. Opioid mechanisms in the control of food consumption and taste preferences. In: Herz, A. ed. Handbook of Experimental Pharmacology, Vol 104/II. Opioids II, Berlin: Springer-Verlag; 1993:239-262.
10. 10. Czirr, S. A.; Reid, L. D. Demonstrating morphine's potentiating effects on sucrose-intake. Brain Res. Bull. 17:639-642; 1986.
11. 11. Di Giulio, A. M.; Restani, P.; Galli, C. L.; Tenconi, B.; La Croix, R.; Gorio, A. Modified ontogenesis of enkephalin and substance P containing neurons after perinatal exposure to morphine. Toxicology, 49:197-201; 1988.
12. 12. Dum, J.; Gramsch, C. H.; Herz, A. Activation of hypothalamic beta-endorphine pools by reward induced by highly palatable food. Pharmacol. Biochem. Behav. 18:443-447; 1983.
13. 13. Enters, E. K.; Guo, H.; Pandey, U.; Ko, D.; Robinson, S. E. The effect of prenatal methadone exposure on development and nociception during the early postnatal period of the rat. Neurotoxicol. Teratol. 13:161-166; 1991.
14. 14. Frederickson, R. C. A.; Smits, S .E. Time course of dependence and tolerance development in rats treated with 'slow release' morphine suspensions. Research Comm. Chemical Pathol. Pharmacol. 5:867-870; 1973.
15. 15. Fujinaga, M.; Mazze, R. I. Teratogenic and postnatal developmental studies of morphine in Sprague-Dawley rats. Teratology, 38:401-410; 1988.
16. 16. Goodwin, G. A.; Moody, C. A.; Spear, L. P. Prenatal cocaine exposure increases the behavioral sensitivity of neonatal rat pups to ligands active at opiate receptors. Neurotoxicol. Teratol. 15: 425-431; 1993.
17. 17. Gosnell, B. A.; Lane, K. E.; Bell, S. M.; Krahn, D. D. Intravenous morphine self-administration by rats with low versus high saccharin preferences. Psychopharmacology. 117:248-252; 1995.
18. 18. Handelmann, G. E.; Quirion, R. Neonatal exposure to morphine increases mu opiate binding in the adult forebrain. Eur. J. Pharmacol. 94:357-358; 1983.
19. 19. Hans, S. L. Developmental consequences of prenatal exposure to methadone. Ann. NY Acad. Sci. 562:195-207; 1989.
20. 20. Hovious, J. R.; Peters, M. A. Analgesic effect of opiates in offspring of opiate-treated female rats. Pharmacol. Biochem. Behav. 21:555-559; 1984.
21. 21. Hovious, J. R.; Peters, M. A. Opiate self-administration in adult offspring of methadone-treated female rats. Pharmacol. Biochem. Behav. 22:949-953; 1985.
22. 22. Iyenger, I.; Rabii, J. Effect of prenatal exposure to morphine on the postnatal development of opiate receptors. Fed. Proc. 41: 354-357; 1982.
23. 23. Kirby, M. L.; DeRossett, S. E.; Holtzman, S. G. Enhanced analgesic response to morphine in adult rats exposed to morphine prenatally. Pharmacol. Biochem. Behav. 17:1161-1164; 1982.
24. 24. Kirby, M. L.; Holtzman, S. G. Effects of chronic opiate administration on spontaneous activity of fetal rats. Pharmacol. Biochem. Behav. 16:263-269; 1982.
25. 3H]naloxone binding in spinal cord of rats treated prenatally with morphine. Neuropharmacol. 22: 303-307; 1983.
26. 26. Koyuncuoglu, H.; Aricioglu, F. Prenatal exposure to morphine or naloxone intensifies morphine dependence at maturity. Pharmacol. Biochem. Behav. 44:939-941; 1993.
27. 27. Lichtblau, L.; Sparber, S. B. Opioids and development: A perspective on experimental models and methods. Neurobehav. Toxicol. Teratol. 6:3-8; 1984.
28. 28. Lieblich, I.; Cohen, E.; Ganchrow, J. R.; Blass, E. M.; Bergmann, F. Morphine tolerance in genetically selected rats induced by chronically elevated saccharine intake. Science, 221:871-873; 1983.
29. 29. Lieblich, I.; Yirmiya, R.; Liebeskind, J. C. Intake of and preference for sweet solutions are attenuated in morphine withdrawn rats. Behav. Neurosci. 105:965-970; 1991.
30. 30. Little, B. B.; Snell, L. M.; Klein, V. R.; Gilstrap, L. C.; Knoll. K. A.; Breckenridge, J. D. Maternal and fetal effects of heroin addiction during pregnancy. J. Reprod. Med. 35:159-162; 1990.
31. 31. Lynch, W. C. Opiate blockade inhibits saccharin intake and blocks normal preference acquisition. Pharmacol. Biochem. Behav. 24: 833-836; 1986.
32. 32. Morabia, A.; Faber, J.; Chee, E.; Zeger, S.; Orsat, E.; Robert, A. Diet and opiate addiction: A quantitative assessment of the diet of non-instituionalized opiate addicts. Br. J. Addict. 84:173-180; 1989.
33. 33. O'Callaghan, J. P.; Holtzman, S. G. Prenatal administration of morphine to the rat: Tolerance to the analgesic effect of morphine in the offspring. J. Pharmacol. exp. Therap. 197:533-544; 1976.
34. 34. Ramsey, N. F.; Niesink, R. J. M.; Van Ree, J. M. Prenatal exposure to morphine enhances cocaine and heroin self-administration in drug-naive rats. Drug Alcohol Depend. 33:41-51; 1993.
35. 35. Rodgers, R. J.; Rendall, J. I. Environmentally induced analgesia: situational factors, mechanisms and significance. In: Rodgers, R. J.; Cooper, S. J., eds. Endorphines, opiates and behavioural processes. New York: John Wiley and Sons; 1988:107-142.
36. 36. Sandman, C. A.; Yessaian, N. Persisting subsensitivity of the striatal dopamine system after fetal exposure to β-endorphin. Life Sci. 39: 1755-1763; 1986.
37. 37. Schaefer, G. J. Opiate antagonists and rewarding brain stimulation. Neurosci. Biobehav. Rev. 12:1-17; 1988.
38. 38. Self, D.W.; Nestler, E. J. Molecular mechanisms of drug reinforcement and addiction. Ann. Rev. Neurosci. 18:463-495; 1995.
39. 39. Spanagel, R.; Herz, A. Shippenberg, T. S. Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proc. Natl. Acad. Sci. 89:2046-2050; 1992.
40. 40. Stinus, L., Cador, M. Le Moal, M. Interaction between endogenous opioids and dopamine within the nucleus accumbens. Ann. New York Acad. Sci., 654, The neurobiology of drug and alocohol addiction: 254-273; 1992
41. 41. Temple, A.; Habas, J.; Paredes, W.; Barr, G. A. Morphine induces downregulation of μ-opioid receptors in neonatal rat brain. Dev. brain Res. 41:129-133; 1988.
42. 42. Temple, A.; Yang, J.; Basheer, R. Prenatal morphine exposure differentially alters expression of opioid peptides in striatum of newborns. Mol. Brain Res. 33:227-232; 1995.
43. 43. Tsang, D.; Ng, S. C. Effect of antenatal exposure to opiates on the development of opiate receptors in rat brain. Brain Res. 188: 199-206; 1980.
44. 44. Valenstein, E. S; Kakolewski, J. W.; Cox, V. C. Sex differences in taste preference for glucose and saccharin solutions. Science, 156:942-943; 1967.
45. 45. Vathy, I. U.; Etgen, A. M.; Barfield, R. J. Effects of prenatal exposure to morphine on the development of sexual behavior in rats. Pharmacol. Biochem. Behav. 22:227-232; 1985
46. 46. Wang, C; Paulska, P.; Perry, B.; Pizzi, W. J.; Schnell, S. H. Effect of perinatal exposure to methadone on brain opioid and α2-adrenergic receptors. Neurobehav. Toxicol. Teratol. 8:399-402; 1986
47. 47. Weiss, G. Food fantasies of incarcerated drug users. Int. J. Addict. 17:905-912; 1982.
48. 48. Wilson, G. S. Clinical studies of infants and children exposed prenatally to heroin. Ann. N.Y. Acad. Sci. 562:183-194; 1989.
49. 49. Wise, R. A. The role of reward pathways in the development of drug dependence. Pharmacol. Ther. 35:227-263; 1987.
50. 50. Yirmiya, R.; Lieblich, I.; Liebeskind, J. C. Reduced saccharin preference in CXBK (opioid receptor deficient) mice. Brain Res. 438:339-342; 1988.
51. 51. Zadina, J. E.; Kastin, A. J. Neonatal peptides affect developing rats: β-endorphin alters nociception and opiate receptors, corticotropin-releasing factor alters corticosterone. Develop. Brain Res. 29:21-29; 1986.
52. 52. Zadina, J. E.; Kastin, A. J.; Coy, D. H.; Adinoff, B. A. Developmental, behavioral, and opiate receptor changes after prenatal or postnatal β-endorphin, CRF, or tyr-MIF-1. Psychoneuroendocrinology, 10:367-383, 1985.
53. 53. Zagon, I. S.; McLaughlin, P. J. Perinatal exposure to methadone alters sensitivity to drugs in adult rats. Neurobehav. Toxicol. Teratol. 6:319-323; 1984.