Purine-rich exon sequences are not necessarily splicing enhancer sequence in the dystrophin gene

Kobe Journal of Medical Sciences

Volumn 47, Issue 5, 2001, Pages 193-202

  Ito, Toshiyuki ^a   Takeshima, Yasuhiro ^a   Sakamoto, Hiroshi ^a   Nakamura, Hajime ^a   Matsuo, Masafumi ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Dystrophin; Purine rich sequence; Splicing; Splicing enhancer sequence

Indexed keywords

DYSTROPHIN; GENE PRODUCT; MESSENGER RNA; PURINE;

ARTICLE; CONTROLLED STUDY; DROSOPHILA; ENHANCER REGION; EXON; GENE INSERTION; GENETIC TRANSCRIPTION; INTRON; NONHUMAN; PROMOTER REGION; RNA SPLICING; SEQUENCE ANALYSIS; SPLICEOSOME;

ANIMALS; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; DYSTROPHIN; ENHANCER ELEMENTS (GENETICS); EXONS; HELA CELLS; HUMANS; INSECT PROTEINS; PURINES; RNA SPLICING;

EID: 0035733068     PISSN: 00232513     EISSN: 18830498     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

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5. Mapping the SF2/ASF binding sites in the bovine growth hormone exonic splicing enhancer
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7. Sorting out the complexity of SR protein functions
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11. An exonic enhancer is required for inclusion of an essential exon in the SMA-determining gene SMN
12. Synergistic interacitons between two distinct elements of a regulated splicing enhancer
13. Duchenne/Becker muscular dystrophy: From molecular diagnosis to gene therapy
14. A complex intronic splicing enhancer from the c-src pre-mRNA activates inclusion of a heterologous exon
15. Induction of exon skipping of the dystrophin transcript in lymphoblastoid cells by transfecting an antisense oligodeoxynucleotide complementary to an exon recognition sequence
16. Exonic splicing enhancers contribute to the use of both 3′ and 5′ splice site usage of rat beta-tropomyosin pre-mRNA
17. RNA splice junctions of different classes of eukaryotes: Sequence statistics and functional implications in gene expression
18. Disruption of the splicing enhancer sequence within exon 27 of the dystrophin gene by a nonsense mutation induces partial skipping of the exon and is responsible for Becker muscular dystrophy
19. An intronic (A/U)GGG repeat enhances the splicing of an alternative intron of the chicken beta-tropomyosin pre-mRNA
20. General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer
21. Six novel transcripts that remove a huge intron ranging from 250 to 800 kb are produced by alternative splicing of the 5′ region of the dystrophin gene in human skeletal muscle
22. Circular dystrophin RNAs consisting of exons that were skipped by alternative splicing
23. The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities
24. Modulation of in vitro splicing of the upstream intron by modifying an intra-exon sequence which is deleted from the dystrophin gene in dystrophin Kobe
25. Polypurine sequences within a downstream exon function as a splicing enhancer
26. The role of exon sequences in splice site selection
27. Physical isolation of nascent RNA chains transcribed by RNA polymerase II: Evidence for cotranscriptional splicing
28. Structural, functional, and protein binding analyses of bovine papillomavirus type 1 exonic splicing enhancers