Lentiviral-mediated gene transfer into haematopoietic stem cells

Journal of Internal Medicine

Volumn 249, Issue 4, 2001, Pages 339-343

  Woods, N B ^a   Mikkola, H ^a   Nilsson, E ^a   Olsson, K ^a   Trono, D ^b   Karlsson, S ^a,c  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Gene therapy; Haematopoietic stem cells; Lentiviral vectors

Indexed keywords

CD34 ANTIGEN; CD38 ANTIGEN; GENOMIC DNA; GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR;

BONE MARROW; BONE MARROW CELL; CELL ASSAY; CELL DIVISION; CELL LINEAGE; COLONY FORMING UNIT GM; CONFERENCE PAPER; DILUTION; EXPERIMENTAL DESIGN; GENE SEQUENCE; GENE TRANSFER; GENETIC TRANSDUCTION; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; LYMPHOID CELL; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGENY; PROMOTER REGION; PROTEIN EXPRESSION; RECIPIENT; SCID MOUSE; STEM CELL; TRANSGENE; UMBILICAL CORD BLOOD; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ANIMALS; ANTIGENS, CD34; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEMATOPOIETIC STEM CELLS; HUMANS; LENTIVIRUS; MICE; MICE, SCID; PROMOTER REGIONS (GENETICS); TRANSDUCTION, GENETIC;

EID: 0035731632     PISSN: 09546820     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2796.2001.00806.x     Document Type: Conference Paper

References (18)

1. Gene therapy for hematopoietic and lymphoid disorders
2. Gene transfer to hematopoietic cells - The clinical experience
3. Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection
4. Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus
5. In vivo delivery and stable transduction of nondividing cells by a lentiviral vector
6. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
7. A third-generation lentivirus vector with a conditional packaging system
8. High-efficiency gene transfer into CD34+ cells with a human immunodeficiency virus type 1-based retroviral vector pseudotyped with vesicular stomatitis virus envelope glyco-protein G
9. Transduction of nondividing cells using pseudo-typed defective high-titer HIV type 1 particles
10. HIV, but not murine leukemia virus, vectors mediate high ef(r)ciency gene transfer into freshly isolated G0/G1 human hematopoietic stem cells
11. Stable transduction of quiescent CD34+CD38- human hematopoietic cells by HIV-1-based lentiviral vectors
12. Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors
13. Transduction of human progenitor hematopoietic stem cells by human immunodeficiency virus type 1-based vectors is cell cycle dependent
14. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy
15. Human growth factor-enhanced regeneration of transplantable human hematopoietic stem cells in nonobese diabetic/severe combined immunodeficient mice
16. Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells
17. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors
18. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery