Use of network analysis of metabolic systems in bioengineering

Bioprocess and Biosystems Engineering

Volumn 24, Issue 6, 2002, Pages 363-372

  Schuster, S ^a   Klamt, S ^b   Weckwerth, W ^c   Moldenhauer, F ^a   Pfeiffer, T ^d  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS   (Germany)

^c MAX PLANCK INSTITUTE OF MOLECULAR PLANT PHYSIOLOGY   (Germany)

^d ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL ENZYME; MICROBIAL ENZYME; PEPTIDE DERIVATIVE;

ANALYTIC METHOD; ARTICLE; BIOENGINEERING; BIOTECHNOLOGY; CONTROLLED STUDY; CORRELATION ANALYSIS; DATA ANALYSIS; ENZYME METABOLISM; GENETIC REGULATION; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MICROBIAL METABOLISM; MYCELIUM; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REACTION TIME; STOICHIOMETRY; YEAST;

FUNGI;

EID: 0035725112     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004490100253     Document Type: Article

References (43)

1. Flux analysis of underdetermined metabolic networks: The quest for the missing constraints
2. Metabolic responses to substrate futile cycling in Escherichia coli
3. Stability of complex reaction networks
4. Strategies for manipulating metabolic fluxes in biotechnology
5. Pathway alignment: Application to the comparative analysis of glycolytic enzymes
6. Exploring the metabolic and genetic control of gene expression on a genomic scale
7. The Escherichia coli MG1655 in silico metabolic genotype: Its definition, characteristics, and capabilities
8. Fat synthesis in adipose tissue. An examination of stoichiometric constraints
9. The small world of metabolism
10. Metabolite profiling for plant functional genomics
11. Multiple reaction mechanisms in catalysis
12. Linear constraint relations in biochemical reaction systems. I. Classification of the calculability and the balanceability of conversion rates
13. The large-scale organization of metabolic networks
14. Composite control of cell function: Metabolic pathways behaving as single control units
15. Calculability analysis in underdetermined metabolic networks illustrated by a model of the central metabolism in purple nonsulfur bacteria
16. Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing
17. Computer-aided synthesis of biochemical pathways
18. The game of the pentose phosphate cycle
19. In vivo quantification of parallel and bidirectional fluxes in the anaplerosis of Corynebacterium glutamicum
20. METATOOL: For studying metabolic networks
21. Metabolic control theory: A structural approach
22. In vivo analysis of metabolic dynamics in Saccharomyces cerevisiae: II. Mathematical model
23. How to recognize monofunctional units in a metabolic system
24. A new anthelmintic cyclodepsipeptide, PF1022A
25. Optimal selection of metabolic fluxes for in vivo measurement. I. Development of mathematical methods
26. Use and limitations of modular metabolic control analysis in medicine and biotechnology
27. On elementary flux modes in biochemical reaction systems at steady state
28. Detection of elementary flux modes in biochemical networks: A promising tool for pathway analysis and metabolic engineering
29. A general definition of metabolic pathways useful for systematic organization and analysis of complex metabolic networks
30. A reconstruction of the metabolism of Methanococcus jannaschii from sequence data
31. A computer program for the algebraic determination of control coefficients in Metabolic Control Analysis
32. Optimization of nonlinear biotechnological processes with linear programming: Application to citric acid production by Aspergillus niger
33. Metabolic capabilities of Escherichia coli: I. Synthesis of biosynthetic precursors and cofactors
34. A discrete model of bacterial metabolism
35. Biosynthesis of PF1022A and related cyclooctadepsipeptides
36. Bidirectional reaction steps in metabolic networks. I. Modeling and simulation of carbon-isotope-labeling experiments
37. Bidirectional reaction steps in metabolic networks. III. Explcit solution and analysis of isotopomer labeling systems