Peptide inhibition of cytokine-stimulated aromatase activity in breast tissue fibroblasts

Journal of Steroid Biochemistry and Molecular Biology

Volumn 79, Issue 1-5, 2001, Pages 165-172

  Parish, D ^a   Purohit, A ^a   Singh, A ^a   Rosankiewicz, J ^a   Ghilchik, M W ^a   Reed, M J ^a  

^a ST MARY S HOSPITAL   (United Kingdom)

Author keywords

Aromatase; Breast cancer; Cytokine; Interleukin 6 (IL 6)

Indexed keywords

AROMATASE; AROMATASE INHIBITOR; CYTOKINE; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; PEPTIDE; PEPTIDE AROHIB; PEPTIDE DP1; PEPTIDE DP2; PEPTIDE DP3; PEPTIDE DP4; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; BREAST CARCINOMA; BREAST CELL; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG DEGRADATION; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; FETAL CALF SERUM; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; INCUBATION TIME; MOLECULAR SIZE; TISSUE SPECIFICITY;

AMINO ACID SEQUENCE; AROMATASE; AROMATASE INHIBITORS; BREAST; ENZYME INHIBITORS; FEMALE; FIBROBLASTS; HUMANS; INTERLEUKIN-6; MOLECULAR SEQUENCE DATA; PEPTIDES; RECEPTORS, INTERLEUKIN-6;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0035714802     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(01)00155-8     Document Type: Conference Paper

References (21)

1. The importance of local synthesis of estrogen within the breast
2. Role of extraglandular estrogen in human endocrinology
3. In situ oestrogen synthesis in normal breast and breast tumour tissue: Effect of treatment with 4-hydroxyandrostenedione
4. Biology of aromatase inhibitors: Pharmacology/endocrinology within the breast
5. Intratumoral aromatase in human breast, endometrial and ovarian malignancies
6. 2 via cyclic AMP leading to activation of promoter II of the CYP19 (aromatase) gene
7. Tissue-specific and hormonally controlled alternative promoters regulate aromatase P450 gene expression in human ovary and fetal tissue
8. Presence of alternatively spliced transcripts of aromatase gene in human breast cancer
9. Regulated CYP19 aromatase transcription in breast stromal fibroblasts
10. Pharmacology of inhibitors of estrogen biosynthesis
11. Aromatase inhibitors
12. Use of aromatase inhibitors in breast cancer
13. Multi-center, phase II trial of exemestane as third-line hormonal therapy of postmenopausal women with metastatic breast cancer
14. Interleukin-1 and interleukin-6 in breast cyst fluid: Their role in regulating aromatase activity in breast cancer cells
15. Stimulation of aromatase activity in breast fibroblasts by tumor necrosis factor α
16. IL-6sR: Release from MCF-7 breast cancer cells and role in regulating peripheral oestrogen synthesis
17. Aromatase activity and interleukin-6 production by normal and malignant breast tissues
18. Studies on the structure and regulation of the human interleukin-6 receptor
19. Soluble receptors for cytokines and growth factors: Generation and biological function
20. Identification of a regulatory domain of the interleukin-6 receptor
21. Interleukin-6 receptor superantogonists are potent inducers of human multiple myeloma cell death