Prevalence and genetic heterogeneity of the reverse transcriptase T69S-S-X insertion in pretreated HIV-infected patients

Intervirology

Volumn 44, Issue 6, 2001, Pages 339-343

  Briones, Carlos ^a   Mas, Antonio ^b   Pérez Olmeda, Mayte ^a   Altisent, Carmen ^c   Domingo, Esteban ^b   Soriano, Vincent ^a,d  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^d NONE   (Spain)

Author keywords

Antiretroviral therapy; HIV; Insertions; Resistance; Reverse transcriptase

Indexed keywords

AMINO ACID; DIDANOSINE; LAMIVUDINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; ZIDOVUDINE;

AMINO ACID SEQUENCE; ARTICLE; CODON; CONTROLLED STUDY; GENE INSERTION; GENE MUTATION; GENETIC HETEROGENEITY; GENOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MONOTHERAPY; NUCLEOTIDE SEQUENCE; PREVALENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SPAIN;

ANTI-HIV AGENTS; DIDANOSINE; DRUG RESISTANCE, VIRAL; GENETIC HETEROGENEITY; HIV INFECTIONS; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; LAMIVUDINE; MALE; MUTAGENESIS; PREVALENCE; REVERSE TRANSCRIPTASE INHIBITORS; SPAIN; ZIDOVUDINE;

INSERTION SEQUENCES;

EID: 0035703618     PISSN: 03005526     EISSN: None     Source Type: Journal    
DOI: 10.1159/000050068     Document Type: Article

References (13)

1. Multiple concurrent reverse transcriptase and protease mutations and multidrug resistance of HIV-1 isolates from heavily treated patients
2. Multiple drug resistance to nucleoside analogues and nonnucleoside reverse transcriptase inhibitors in an efficiently replicating human immunodeficiency virus type 1 patient strain
3. Mutations in the pol gene of human immunodeficiency virus type 1 in infected patients receiving didanosine and hydroxyurea combination therapy
4. A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors
5. A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance
6. Insertion of two amino acids combined with changes in reverse transcriptase containing tyrosine-215 of HIV-1 resistant to multiple nucleoside analogs
7. Line probe assay for rapid detection of drug-selected mutations in the human immunodeficiency virus type 1 reverse transcriptase gene
8. An enhanced-sensitivity branched-DNA assay for quantification of human immunodeficiency virus type 1 RNA in plasma
9. Prevalence of genotypic resistance to nucleoside analogues in antiretroviral-naive and antiretroviral-experienced HIV-infected patients in Spain
10. Multiple dideoxynucleoside analogue-resistant (MddNR) HIV-1 strains isolated from patients from different European countries
11. Insertions into the β3-β4 hairpin loop of HIV-1 reverse transcriptase reveal a role for fingers subdomain in processive polymerization
12. Stable rearrangements of the β3-β4 hairpin loop of HIV-1 reverse transcriptase in plasma viruses from patients receiving combination therapy
13. The processivity of DNA synthesis exhibited by drug-resistant variants of human immunodeficiency virus type-1 reverse transcriptase