The effect of intravesical capsaicin on the suburothelial innervation in patients with detrusor hyper-reflexia

BJU International

Volumn 85, Issue 3, 2000, Pages 238-245

  Dasgupta, P ^a   Chandiramani, V A ^a   Beckett, A ^a   Scaravilli, F ^a   Fowler, Clare J ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

Author keywords

Detrusor hyper reflexia; Intravesical capsaicin; Nerve density; PGP 9.5; S100

Indexed keywords

CAPSAICIN; PROTEIN S 100;

ADULT; AGED; ARTICLE; BIOPSY; BLADDER CAPACITY; BLADDER INNERVATION; CELL DENSITY; CLINICAL ARTICLE; CLINICAL TRIAL; COMPUTER ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYSTOMETRY; CYSTOSCOPE; CYSTOSCOPY; DETRUSOR MUSCLE; FEMALE; FORCEPS; HUMAN; HUMAN TISSUE; HYPERREFLEXIA; MALE; PRIORITY JOURNAL; UROTHELIUM;

ADMINISTRATION, INTRAVESICAL; ADULT; AGED; ANTIGENS, DIFFERENTIATION; CAPSAICIN; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; REFLEX, ABNORMAL; S100 PROTEINS; UBIQUITIN THIOLESTERASE; URINARY BLADDER DISEASES; UROTHELIUM;

EID: 0033950419     PISSN: 14644096     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-410X.2000.00427.x     Document Type: Article

References (38)

1. 1 Fowler CJ, Jewkes D, McDonald WI, Lynn B, de Groat WC. Intravesical capsaicin for neurogenic bladder dysfunction. Lancet 1992; 339: 1239
2. 2 Cruz F, Guimaracs M, Silva C, Rio ME, Coimbra A, Reis M. Desensitization of bladder sensory fibres by intravesical capsaicin has long lasting clinical and urodynamic effects in patients with hyperactive or hypersensitive bladder dysfunction. J Urol 1997; 157: 585-9
3. 3 de Seze M, Wiart L, Joseph PA, Dosque JP, Mazaux JM, Barat M. Capsaicin and neurogenic detrusor hyperreflexia: a double-blind placebo-controlled study in 20 patients with spinal cord lesions. Neurourol Urodyn 1998; 17: 513-23
4. 4 Dasgupta P, Chandiramani V, Parkinson MC, Beckett A, Fowler CJ. Treating the human bladder with capsaicin: is it safe? Eur Urol 1998; 33: 28-31
5. 5 De Ridder D, Chandiramani V, Dasgupta P, Van Poppel H, Baert L, Fowler CJ. Intravesical capsaicin as a treatment for refractory detrusor hyperreflexia: a dual center study with long-term followup. J Urol 1997; 158: 2087-92
6. 6 Dasgupta P, Fowler CJ. Chillies: from antiquity to urology. Br J Urol 1997; 80: 845-52
7. 7 Fowler CJ, Beck RO, Gerrard S, Betts CD, Fowler CG. Intravesical capsaicin for treatment of detrusor hyperreflexia. J Neurol Neurosurg Psychiatry 1994; 57: 169-73
8. 8 Lynn B. Capsaicin: action on nociceptive C-fibres and therapeutic potential. Pain 1990; 41: 61-9
9. 9 Scadding JW. The permanent anatomical effects of neonatal capsaicin on somatosensory nerves. J Anat 1980; 131: 471-82
10. 10 Jancso G, Kiraly E, Joo F, Such G, Nagy A. Selective degeneration by capsaicin of a subpopulation of primary sensory neurons in the adult rat. Neurosci Lett 1985; 59: 209-14
11. 11 Sharkey KA, Williams RG, Scultzberg M, Dockray GJ. Sensory substance P-innervation of the urinary bladder: possible site of action of capsaicin in causing urine retention in rats. Neuroscience 1983; 10: 861-8
12. 12 Fahrenkrug J, Hannibal J. Pituitary adenylate cyclase activating polypeptide immunoreactivity in capsaicin-sensitive nerve fibres supplying the rat urinary tract. Neuroscience 1998; 83: 1261-72
13. 13 Lynn B. The immediate and long-term effects of applying capsaicin to cutaneous nerves. Acta Physiol Hung 1986; 69: 287-94
14. 14 Jessel TM, Iversen LL, Cuello AC. Capsaicin-induced depletion of substance P from primary neurons. Brain Res 1978; 152: 183-8
15. 15 Dixon JS, Gilpin CJ. Presumptive sensory axons of the human urinary bladder. A fine ultrastructural study. J Anat 1987; 151: 199-207
16. 16 Stefansson K, Wollman RL, Moore BW. Distribution of S100 protein outside the central nervous system. Brain Res 1982; 234: 309-17
17. 17 Sato O, Maeda T, Iwanga T, Kobayashi S. Innervation of the incisors and periodontal ligament in several rodents: an immunohistochemical study of neurofilament protein and glial-specific S 100 protein. Acta Anat Basel 1989; 134: 94-9
18. 18 Moore BW. A soluble protein characteristic of the nervous system, Biochem Biophys Res Commun 1965; 19: 739-44
19. 19 Gu J, Polak JM, Deane A, Cocchia D, Michetti F. Increase of S-100 immunoreactivity in the urinary bladder from patients with multiple sclerosis. An indication of peripheral neuronal lesion. Am J Clin Pathol 1984; 82: 649-54
20. 20 Van Poppel H, Stessens R, Lazarides M, Van Damme B, Carton H, Baert L. Neuropathological examination of the alterations of the intrinsic innervation in multiple sclerosis cystopathy. Urol Int 1989; 44: 321-6
21. 21 Van Poppel H, Baert L, Stessens R, Van Stapel MJ, Van Damme B, Carton H. Histochemical assessment of the intrinsic innervation of the normal urinary bladder. Urol Int 1988; 43: 145-8
22. 22 Johnson PC, Beggs JL, Olafsen AG, Watkins CJ. Unmyelinated nerve fiber estimation by immunocytochemistry. Correlation with electron microscopy. J Neuropathol Exp Neurol 1994; 53: 176-83
23. 23 Dasgupta P, Chandiramani V, Fowler CJ et al. Intravesical capsaicin: its effects on nerve densities in the human urinary bladder. Neurourol Urodyn 1996; 15: 373A
24. 24 Dasgupta P, Chandiramani VA, Beckett A, Fowler CJ, Crowe R, Shah PJR. Flexible cystoscopic biopsies for evaluation of nerve densities in the suburothelium of the human urinary bladder. Br J Urol 1997; 80: 490-2
25. 25 Chandiramani VA, Peterson T, Duthie GS, Fowler CJ. Urodynamic changes during therapeutic intravesical instillations of capsaicin. Br J Urol 1996; 77: 792-7
26. 26 de Groat WC, Araki I, Vizzard MA et al. Developmental and injury induced plasticity in the micturition reflex pathway. Behav Brain Res 1998; 92: 127-40
27. 27 Smet PJ, Moore KH, Jonavicius J. Distribution and colocalization of calcitonin gene-related peptide, tachykinins, and vasoactive intestinal polypeptide in normal and idiopathic unstable human urinary bladder. Lab Invest 1997; 77: 37-49
28. 28 Hiura A, Ishizuka H. Quantitative electron-microscopic analyses of pulpal nerve fibres in the mouse lower incisor after neonatal capsaicin treatment. Arch Oral Biol 1992; 37: 1085-90
29. 29 Pini A, Baranowski R, Lynn B. Long-term reduction in the number of C-fibre nociceptors following capsaicin treatment of a cutaneous nerve in adult rats. Eur J Neurosci 1990; 2: 89-97
30. + currents in rabbit Schwann cells. Proc R Soc Lond B Biol Sci 1994; 22: 259-65
31. 31 Maggi CA, Santicioli P, Geppetti P et al. The effect of calcium free medium and nifedipine on the release of substance P-like immunoreactivity and contractions induced by capsaicin in the isolated guinea-pig and rat bladder. Gen Pharmacol 1989; 20: 445-56
32. 32 Caterina MJ, Nschumaker MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997; 389: 816-24
33. 33 Hussain IF, Sakakibara R, Dasgupta P, Fowler CJ. Light microscopic evaluation of lamina propria nerve density in normal human bladder biopsies. Neurourol Urodyn 1998; 17: 449A
34. 34 Fitzgerald M. Capsaicin and sensory neurones - a review. Pain 1983; 15: 109-30
35. 35 Dasgupta P, Fowler CJ, Stephen RL. Electromotive drug administration of lidocaine to anesthetize the bladder before intravesical capsaicin. J Urol 1998; 159: 1857-61
36. 36 Craft RM, Porreca F. Tetracaine attenuates irritancy without attenuating desensitization produced by intravesical rcsiniferatoxin in the rat. Pain 1994; 57: 351-9
37. 37 Wiart L, Joseph PA, Petit H et al. The effects of capsaicin on the neurogenic hyperreflexic detrusor. A double blind placebo controlled study in patients with spinal cord disease. Preliminary results. Spinal Cord 1998; 36: 95-9
38. 38 Byrne DS, Das A, Sedor J et al. Effect of intravesical capsaicin and vehicle on bladder integrity in control and spinal cord injured rats. J Urol 1998; 159: 1074-8