Neuronal DNA damage correlates with overexpression of interleukin-1β converting enzyme in APPV717F mice

Neurobiology of Aging

Volumn 22, Issue 6, 2001, Pages 895-902

  Sheng, J G ^a,b   Mrak, R E ^c   Jones, R A ^a,d   Brewer, M M ^a   Zhou, X Q ^a   McGinness, J ^a   Woodward, S ^a   Bales, K ^e   Paul, S M ^e   Cordell, B ^f   Griffin, W S T ^a,c,d  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

^e ELI LILLY AND COMPANY   (United States)

^f SCIOS INC   (United States)

Author keywords

Amyloid; APPV717F transgenic mice; DNA degradation; ICE; IL 1 converting enzyme; RT PCR; Transgenic mice; TUNEL

Indexed keywords

AMYLOID BETA PROTEIN; CYSTEINE PROTEINASE; CYTOKINE; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA;

AGE; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; CORRELATION FUNCTION; DNA DAMAGE; ENZYME ACTIVITY; FEMALE; GLIA; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MOLECULAR WEIGHT; MOUSE; MOUSE STRAIN; NERVE CELL; NERVE CELL LESION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALZHEIMER DISEASE; ANIMALS; CASPASE 1; DNA DAMAGE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MICE; MICE, TRANSGENIC; NEURONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SILVER STAINING;

EID: 0035690892     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(01)00298-6     Document Type: Article

References (52)

1. Human ICE/CED-3 protease nomenclature
2. DNA damage, and apoptosis in Alzheimer's disease: Colocalization with c-jun immunoreactivity, relationship to brain area, and effect of postmortem delay
3. S100 stimulates calcium fluxes in glial, and neuronal cells
4. Differential regulation of C3 gene expression in human astroglioma cells by interferon-gamma and IL-1 beta
5. Generation of biologically active IL-1β by proteolytic cleavage of the inactive precursor
6. A decomposition product of a contaminant implicated in L-tryptophan eosinophilia myalgia syndrome affects spinal cord neuronal cell death, and survival through stereospecific, maturation, and partly IL-1-dependent mechanisms
7. Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimerβ/A4 amyloid protein precursor
8. Evidence for caspase-mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease
9. A potential role for apoptosis in neurodegeneration, and Alzheimer's disease
10. In vivo study of motoneuron death induced by nerve injury in mice deficient in the caspase 1/IL-1β-converting enzyme
11. The role of IL-1 in disease
12. Expression of amyloid precursor protein mRNAs in endothelial, neuronal and glial cells: Modulation by IL-1
13. Association of an interleukin1α polymorphism with Alzheimer's disease
14. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
15. Interleukin-1 injected into mammalian brain stimulates astrogliosis, and neovascularization
16. Inteleukin-1 expression in different plaque types in Alzheimer's disease
17. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
18. Senescence-accelerated overexpression of S100β in brain of SAMP6 mice
19. Glial-neuronal interactions in Alzheimer's disease: The potential role of a 'cytokine cycle' in disease progression
20. Association of early onset Alzheimer's disease with an IL-1α gene polymorphism
21. The neuropathological changes associated with normal brain aging
22. S100β stimulates inducible nitric oxide synthase activity, and mRNA levels in rat cortical astrocytes
23. Aβ deposition is associated with neuropil changes but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse
24. Possible role of neuronal apoptosis in Alzheimer's disease
25. Neuronal death in developmental models: Possible implications in neuropathology
26. Activation of CPP32 during apoptosis of neurons and astrocytes
27. Identification of a monocyte specific pre-interleukin 1β convertase activity
28. Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ
29. S100β induction of the proinflammatory cytokine IL-6 in neurons: Implications for Alzheimer's pathogenesis
30. S100β increases levels of β-amyloid precursor protein, and its encoding mRNA in rat neuronal cultures
31. Purification and characterization of active human IL-1β-converting enzyme from THP.1 monocytic cells
32. Interleukin-1, and the immunogenetics of Alzheimer's disease
33. Glial cytokines in Alzheimer's disease: Review and pathogenic implications
34. Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients
35. Association of interleukin-1 gene polymorphisms with Alzheimer's disease
36. Effect of postmortem interval on in situ end-labelling of DNA oligonucleosomes
37. Confirmation of the genetic association of IL-1A with early onset sporadic Alzheimer's disease
38. Overexpression of the neuritotrophic cytokine S100β precedes the appearance of neuritic β-amyloid plaques in APPV717F mice
39. Progressive neuronal DNA damage associated with neurofibrillary tangle formation in Alzheimer's disease
40. Progressive neuronal injury associated with amyloid plaque formation in Alzheimer's disease
41. In vivo and in vitro evidence supporting a role for inflammatory cytokine interleukin-1 as a driving force in Alzheimer's pathogenesis
42. Substrate specificity of the protease that processes human IL-1β
43. Evidence for apoptotic cells death in Alzheimer's disease
44. Alzheimer's disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis
45. Immunohistochemical evidence for apoptosis in Alzheimer's disease
46. IL-1β converting enzyme
47. Endonuclease activation following focal ischemic injury in the rat brain
48. Neuropathology in controls and demented subjects from the Baltimore Longitudinal Study of Aging
49. In situ labeling of dying cortical neurons in normal aging and in Alzheimer's disease: Correlations with senile plaques and disease progression
50. Caspase-2 mediates neuronal cell death induced by β-amyloid
51. Induction of IL-1β converting enzyme (ICE) in murine microglia by lipopolysaccharide
52. Increased interleukin-1β converting enzyme expression, and activity in Alzheimer's disease